Lung carcinosarcoma as a rare biphasic sarcomatoid carcinoma: a case report

Sanyal, Kaushik; Sabanathan, K.

doi:10.4076/1757-1626-2-7968

Cited by 13 publications

(12 citation statements)

References 7 publications

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“…According to the 2004 WHO classification of lung tumors, carcinosarcomas are defined as tumors consisting of an admixture of malignant epithelial and mesenchymal elements. It is included in a group of poorly differentiated non-small cell lung carcinomas that contain a component of sarcomatoid differentiation, so called sarcomatoid carcinoma [2,3,5,6].…”

Section: Discussionmentioning

confidence: 99%

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Clinical and In-Silico study of COVID?19 patients using Thymus capitatus extract as adjuvant Therapy

Gbaj¹

2021

IJCCR

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Thymus capitatus extract has been considered a promise as antiviral agent against COVID‑19 viruses. We hypothesized that Thymus capitatus components may interact with key protein targets of COVID‑19 (coronavirus 2 (SARS-CoV-2) causing severe acute respiratory syndromes. Molecular docking analysis was carried out using 31 components of Thymus capitatus with SARS-CoV-2 protease enzyme (6LU7) and spike glycoprotein (6VSB). The compounds with the best normalized docking scores to protease enzyme were allo-Aromadendrene (-6.3 kcal/mole), spathulenol (-6.6 kcal/mole) and ledene (-6.8 kcal/mole). The best docking ligands for spike glycoprotein were allo-Aromadendrene (-6.6 kcal/mole), spathulenol (-6.6 kcal/mole) and ledene (-7.3 kcal/mole). All Thymus capitatus components may act synergistically to produce the therapeutic action. Thymus capitatus components may potentiate the effect of prednisolone, azithromycin and other medicines used to treat COVID-19 patients.

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Section: Discussionmentioning

confidence: 99%

“…Pulmonary carcinosarcoma is a rare and highly malignant lung neoplasm characterized by a biphasic histopathological pattern consisting of both epithelial and sarcomatous components (1)(2)(3)(4)(5)(6). It usually affects men, generally heavy smokers, between the fifth and eighth decades of life (2,3).…”

Section: Introductionmentioning

confidence: 99%

Clinical and In-Silico study of COVID?19 patients using Thymus capitatus extract as adjuvant Therapy

Gbaj¹

2021

IJCCR

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“…This makes it hard to distinguish them from each other. In endobronchial tumors, coughing and blood-tinged sputum usually occur, but peripheral tumors are asymptomatic [14]. However, no paraneoplastic syndrome was reported to accompany PSC, although such symptoms occurred in about 15–20% of small cell lung carcinomas (SCLCs) and 5–8% of NSCLCs [15].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary sarcomatoid carcinoma: a

Shen¹,

Lin²,

Lin³

et al. 2013

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Sarcomatoid carcinoma (SC) is a rare primary malignant tumor in which both carcinomatous and sarcomatous elements occur. It can occur in many different organs and anatomical locations, such as the skin, thyroid gland, bone, urinary tract, breast, pancreas, liver and other areas. Of them, pulmonary sarcomatoid carcinoma (PSC) is a rare malignant cancer composed of sarcoma and sarcoma-like tumors with spindle or giant cell features. Here a case of a 75-year-old Chinese man with a six-month history of cough and hemoptysis is reported. Chest X-ray showed a tumor shadow in the left lung field. Chest computed tomography (CT) scan showed a lobulated mass in his left hilum and even the left pulmonary artery. Pleomorphic interstitial cells were found by bronchoscopic brushing. To establish a definitive diagnosis for PSC, a left pneumonectomy was performed. The pathological stage was IIB (pT2N1M0) based on the tumor node metastasis (TNM) staging system. The tumor's pathology, histology, immunohistochemistry and treatment methods are discussed.

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“…[1] Although the development of carcinosarcoma is more closely associated with smoking, there are cases reported to be caused by asbestos exposure. [2,3] We present a carcinosarcoma case in an active smoker with interesting macroscopic views. The longitudinal section of the postpneumonectomy pathology specimen extends to the left main bronchus and all lower subsegment bronchi in the shape of a glove finger, filling the airways without invading the wall.…”

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confidence: 99%

Squamotous-type sarcomatoid carcinoma of the lung with rhabdomyosarcomatous components

et al. 2012

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Lung carcinosarcoma is an infrequently biphasic tumor composed of carcinomatous and sarcomatous components. It is divided into endobronchial (squamous-type) and peripheral (glandular type) categories. The carcinomatous component is usually a squamous carcinoma, and the sarcomatous component usually resembles a fibrosarcoma or a malignant fibrous histiocytoma. The presence of rhabdomyoblastic differentiation in such neoplasms is exceedingly rare. There are strong associations with smoking and asbestosis. In this study, we describe a unique case of a 43-year-old man with a 75 packet/year smoking history in whom a rare mixed malignant tumor of the lung was diagnosed and treated by left pneumonectomy. Histological examination of the resected specimen showed squamous cell carcinoma and rhabdomyosarcoma components. Although rare, the association of a sarcomatoid carcinoma of the lung with squamous cell carcinoma and rhabdomyosarcomatous component is possible and should be kept in mind when dealing with these unusual tumors.

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Lung carcinosarcoma as a rare biphasic sarcomatoid carcinoma: a case report

Cited by 13 publications

References 7 publications

Clinical and In-Silico study of COVID?19 patients using Thymus capitatus extract as adjuvant Therapy

Clinical and In-Silico study of COVID?19 patients using Thymus capitatus extract as adjuvant Therapy

Pulmonary sarcomatoid carcinoma: a

Squamotous-type sarcomatoid carcinoma of the lung with rhabdomyosarcomatous components

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