Lung cavitation in primary antiphospholipid syndrome

Bertoli, Ana M.; Tabares, Aldo; Casas, Juan P.; Saurit, Verónica; Caeiro, Francisco; Alvarellos, A

doi:10.1191/0961203302lu138cr

Cited by 7 publications

(7 citation statements)

References 8 publications

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“…Bertoli et al reported a case of thromboembolic disease with secondary aseptic cavitary lung lesions. 6 Our patient had definite lupus and secondary antiphospholipid syndrome. His cavitary lung lesions resolved after starting the immunosuppressive and antithrombotic treatment.…”

Section: Discussionmentioning

confidence: 64%

Cavitary lung lesions in systemic lupus: an unusual presentation

Torok

Malouh

Kasmani

et al. 2010

Lupus

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Lupus is a multisystem disease with varied clinical manifestations. Cavitary lung lesions in lupus could be secondary to infections, embolism, or underlying vasculitis. We report a man who presented with lung cavitations and was diagnosed as lupus, secondary antiphospholipid syndrome, and plasma cell dyscrasia. The lesions resolved after the initiation of immunosuppressive therapy. All the previous case reports have been reviewed and the possible mechanisms underlying this association are discussed.

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Section: Discussionmentioning

confidence: 64%

Cavitary lung lesions in systemic lupus: an unusual presentation

Torok

Malouh

Kasmani

et al. 2010

Lupus

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“…In those with collateral arteries, the absence of protective proximal stenosis can trigger focal pulmonary vascular disease, with the propensity for stasis, thrombosis, and haemorrhage. Pulmonary infarction in this setting can result in both aseptic pulmonary cavitation and development of lung abscesses 2 – 4 This may be similar to the propensity to infection described secondary to micro-infarction in sickle cell anemia 5…”

Section: Discussionmentioning

confidence: 75%

Lung Abscess in Adults with Tetralogy of Fallot and Pulmonary Atresia

2010

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We describe 5 adults with tetralogy of Fallot and pulmonary atresia who developed lung abscesses, including some infected with atypical microbial pathogens, with important morbidity. We hypothesize that patients with such anatomy are at risk for chronic pulmonary infection due to hypo-perfusion of the pulmonary parenchyma. This previously unreported clinical association should be considered in the differential diagnosis of patients with tetralogy of Fallot and pulmonary atresia who alter their respiratory state.

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“…25 All of our patients with pulmonary infarction had positive antiphospholipid antibodies fulfilling the diagnostic criteria of definite APS without other risk factors associated with venous thromboembolism or pulmonary embolism, similar to the previously reported patients in the literature. [10][11][12] Nevertheless, hypercoagulability due to nephrotic syndrome in membranous lupus nephritis (cases no. 1 and 3) could contribute to the development of lung infarcts in these reported cases.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 Furthermore, there were only a few reported cases of lung infarcts in patients with APS. [10][11][12][13] Given that pulmonary infarction has the image feature of lung consolidation which is difficult to differentiate from pneumonia on chest X-rays, and untreated patients are associated with potential mortality, clinically suspected cases demand prompt diagnosis and immediate management. 14 There is a high incidence and prevalence of lupus patients with characteristic presentations of APS in Taiwan.…”

Section: Introductionmentioning

confidence: 99%

A retrospective study of pulmonary infarction in patients with systemic lupus erythematosus from southern Taiwan

et al. 2011

Lupus

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Since large-scale reports of pulmonary infarction in systemic lupus erythematosus (SLE) are limited, a retrospective study was performed for this manifestation in 773 hospitalized patients in southern Taiwan from 1999 to 2009. Pulmonary infarction was defined as the presence of pulmonary embolism, persistent pulmonary infiltrates, and characteristic clinical symptoms. Demographic, clinical, laboratory, and radiological images data were analyzed. There were 12 patients with pulmonary embolism and 9 of them had antiphospholipid syndrome (APS). Six patients (19 to 53 years, average 38.2 ± 12.6) with 9 episodes of lung infarction were identified. All cases were APS and four episodes had coincidental venous thromboembolism. There were four episodes of bilateral infarction and seven episodes of larger central pulmonary artery embolism. Heparin therapy was routinely prescribed and thrombolytic agents were added in two episodes. Successful recovery was noted in all patients. In conclusion, there was a 0.8% incidence of pulmonary infarction in patients with SLE, all with the risk factor of APS. Differentiation between pulmonary infarction and pneumonia in lupus patients should be made; they have similar chest radiography with lung consolidation but require a different clinical approach in management. Although this report is a retrospective study with relatively small numbers of lupus patients with lung infarcts, our observation might provide beneficial information on the clinical features and radiological presentations during the disease evolution of pulmonary infarction in SLE with APS.

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Lung cavitation in primary antiphospholipid syndrome

Cited by 7 publications

References 8 publications

Cavitary lung lesions in systemic lupus: an unusual presentation

Cavitary lung lesions in systemic lupus: an unusual presentation

Lung Abscess in Adults with Tetralogy of Fallot and Pulmonary Atresia

A retrospective study of pulmonary infarction in patients with systemic lupus erythematosus from southern Taiwan

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