Lung clearance index and lung ultrasound in cystic fibrosis children

Ciuca, I.M.; Dediu, Mihaela; Pop, Liviu

doi:10.1183/13993003.congress-2018.oa4988

Cited by 4 publications

(5 citation statements)

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“…In addition to its diagnostic practicality, LUS also seems to be effective for detection of exacerbations [ 40 ], showing good correlation with lung function [ 17 , 41 ]. Few studies have investigated the significance of LUS in CF [ 15 , 16 , 17 , 40 , 41 ], but emerging evidence remains to be shown. Our study is the first to describe the LUS artefacts corresponding to CT lung lesions, quantifying all lung injuries potentially detected by LUS.…”

Section: Discussionmentioning

confidence: 99%

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Lung Ultrasound in Children with Cystic Fibrosis in Comparison with Chest Computed Tomography: A Feasibility Study

et al. 2022

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Background: Cystic fibrosis (CF) lung disease determines the outcome of this condition. For lung evaluation processes, computed tomography (CT) is the gold standard, but also causes irradiation. Lately, lung ultrasound (LUS) has proven to be reliable for the diagnosis of consolidations, atelectasis, and/or bronchiectasis. The aim of our study was to evaluate the value of a newly conceived LUS score by comparing it to the modified Bhalla CT score. A further aim was to evaluate the correlation between the score and the lung clearance index (LCI). Methods: Patients with CF were screened by LUS, followed by a CT scan. Spearman’s test was used for correlations. Results: A total of 98 patients with CF were screened, and 57 were included in the study; their mean age was 11.8 ± 5.5 (mean ± SD) years. The mean LUS score was 5.88 ± 5.4 SD. The LUS CF score had a very strong correlation with the CT score of rs = 0.87 (p = 0.000). LUS showed a good sensibility for detecting atelectasis (Se = 83.7%) and consolidations (Se = 94.4%). A lower Se (77.7%) and Sp (9%) were found for cylindrical bronchiectasis. Conclusion: Our study shows that LUS and the lung CF score are parameters that can be used with a complementary role in the diagnosis and monitoring of CF lung disease in children.

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Section: Discussionmentioning

confidence: 99%

“…Studies have shown that LUS value in CF exacerbations [ 14 ] correlates with lung function tests [ 15 ], and reliable correlations between LUS and Chrispin–Norman X-ray score [ 16 ] or modified Bhalla CT score have been published [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Lung Ultrasound in Children with Cystic Fibrosis in Comparison with Chest Computed Tomography: A Feasibility Study

et al. 2022

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“…The reliability of a biomarker is contingent on factors such as accessibility, sensitivity, and specificity. In the context of CF, pulmonary biomarkers are increasingly employed to examine disease action and assess the response to therapy in individuals [95]. Recently, Su et al [96] conducted research indicating that an increased biosynthesis of fatty acids plays a crucial role in CFX resistance development in P. aeruginosa.…”

Section: Potential Biomarkers For Identifying Cfx Resistance In Lrtismentioning

confidence: 99%

Ciprofloxacin-Loaded Inhalable Formulations against Lower Respiratory Tract Infections: Challenges, Recent Advances, and Future Perspectives

Panthi,

Fairfull-Smith,

Islam

2024

Pharmaceutics

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Inhaled ciprofloxacin (CFX) has been investigated as a treatment for lower respiratory tract infections (LRTIs) associated with cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and bronchiectasis. The challenges in CFX effectiveness for LRTI treatment include poor aqueous solubility and therapy resistance. CFX dry powder for inhalation (DPI) formulations were well-tolerated, showing a remarkable decline in overall bacterial burden compared to a placebo in bronchiectasis patients. Recent research using an inhalable powder combining Pseudomonas phage PEV20 with CFX exhibited a substantial reduction in bacterial density in mouse lungs infected with clinical P. aeruginosa strains and reduced inflammation. Currently, studies suggest that elevated biosynthesis of fatty acids could serve as a potential biomarker for detecting CFX resistance in LRTIs. Furthermore, inhaled CFX has successfully addressed various challenges associated with traditional CFX, including the incapacity to eliminate the pathogen, the recurrence of colonization, and the development of resistance. However, further exploration is needed to address three key unresolved issues: identifying the right patient group, determining the optimal treatment duration, and accurately assessing the risk of antibiotic resistance, with additional multicenter randomized controlled trials suggested to tackle these challenges. Importantly, future investigations will focus on the effectiveness of CFX DPI in bronchiectasis and COPD, aiming to differentiate prognoses between these two conditions. This review underscores the importance of CFX inhalable formulations against LRTIs in preclinical and clinical sectors, their challenges, recent advancements, and future perspectives.

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“…A small study compared a LUS score (evaluating only the presence of consolidation and B-lines pattern) with the modified Bhalla CT score and showed a correlation between the two methods and some partial correlation with the lung function expressed by FEV1 and FVC [70]. Another study evaluated LUS changes compared to lung function expressed by the lung clearance index in CF children patients, revealing a consistent correlation between structure and function but only in patients with severe lung deterioration [71]. No correlation was found in patients with mild disease, because of the lack of US artefacts specific for early CF lung disease.…”

Section: Cystic Fibrosismentioning

confidence: 99%

Lung ultrasound in children, WFUMB review paper (part 2)

et al. 2021

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Ultrasound (US) is an ideal diagnostic tool for paediatric patients owning to its high spatial and temporal resolution, real-time imaging, and lack of ionizing radiation and bedside availability. In the current World Federation of Societies for Ultra-sound in Medicine and Biology (WFUMB) paper series so far (part I) the topic has been introduced and the technical require-ments explained. In the present paper the use of US in the lung in paediatric patients is analysed. Lung diseases including the interstitial syndrome, bacterial pneumonia and viral infections, CoViD findings, atelectasis, lung consolidation, bronchiolitis and congenital diseases of the respiratory system including congenital pulmonary airway malformation (CPAM) and sequester but also pneumothorax are discussed.

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Lung clearance index and lung ultrasound in cystic fibrosis children

Cited by 4 publications

References 0 publications

Lung Ultrasound in Children with Cystic Fibrosis in Comparison with Chest Computed Tomography: A Feasibility Study

Lung Ultrasound in Children with Cystic Fibrosis in Comparison with Chest Computed Tomography: A Feasibility Study

Ciprofloxacin-Loaded Inhalable Formulations against Lower Respiratory Tract Infections: Challenges, Recent Advances, and Future Perspectives

Lung ultrasound in children, WFUMB review paper (part 2)

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