2014
DOI: 10.1016/j.jcf.2013.09.005
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Lung clearance index: Evidence for use in clinical trials in cystic fibrosis

Abstract: The ECFS-CTN Standardisation Committee has undertaken this review of lung clearance index as part of the group's work on evaluation of clinical endpoints with regard to their use in multicentre clinical trials in CF. The aims were 1) to review the literature on reliability, validity and responsiveness of LCI in patients with CF, 2) to gain consensus of the group on feasibility of LCI and 3) to gain consensus on answers to key questions regarding the promotion of LCI to surrogate endpoint status. It was conclud… Show more

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Cited by 175 publications
(142 citation statements)
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“…Also, LCI is superior to FEV 1 in detecting small changes in patients with mild lung disease. Our data support a recent expert statement that LCI is particularly useful in young children and in patients with early or mild CF lung disease when FEV 1 is within normal range [10].…”
Section: Discussionsupporting
confidence: 89%
“…Also, LCI is superior to FEV 1 in detecting small changes in patients with mild lung disease. Our data support a recent expert statement that LCI is particularly useful in young children and in patients with early or mild CF lung disease when FEV 1 is within normal range [10].…”
Section: Discussionsupporting
confidence: 89%
“…Even within the same subject, either on the same test occasion, or between test occasions the variability remains small [34]. However, all measures of the variability (both within and between tests) are much greater in patients with CF.…”
Section: What Is a Clinically Meaningful Lci Change?mentioning
confidence: 94%
“…In the past 5 years there has been a growing interest in the lung clearance index (LCI) as an outcome for clinical trials in CF patients [34]. The LCI is the primary and simplest measure of the Multiple Breath Washout (MBW) test.…”
Section: The Lung Clearance Indexmentioning
confidence: 99%
“…Lung Clearance Index (LCI) derived from multiple breath washout (MBW) is a sensitive measure of ventilation inhomogeneity1 2 and a robust surrogate outcome measure of the severity of lung disease in cystic fibrosis (CF)3 which has begun to be incorporated into clinical trials 45 It also shows promise as a sensitive outcome measure in idiopathic bronchiectasis6 and asthma 7.…”
Section: Introductionmentioning
confidence: 99%