Lung Deposition of Qvar (Hfa134a-Bdp) in Newborn Infants With Bronchopulmonary Dysplasia (Bpd)

Dolovich, Myrna; Millar, David; Sterling, Lori; Rhem, Rod G.; Bosco, Andrew P.; Kirpalani, Haresh

doi:10.1378/chest.128.4_meetingabstracts.351s

Cited by 2 publications

(1 citation statement)

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“…However, the differences in methodology across studies preclude any firm conclusions regarding relative efficacies between the various delivery devices. Higher tidal volume, 11‐13 larger ETT size, 11‐13 lack of humidification in the circuit, 13 and use in vivo‐setting 26 were some of the key differences in methods/experimental design between previous studies and ours that preclude direct comparisons in delivery efficiency. In addition, it is unclear whether budesonide as used in our model has different biochemical characteristics which may explain the difference in results from previous studies.…”

Section: Discussionmentioning

confidence: 84%

Efficiency of budesonide delivery via a mesh nebulizer in an in‐vitro neonatal ventilator model

Esmaeilizand

Rocha

Harrison

et al. 2020

Pediatric Pulmonology

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Objective To determine the delivery efficiency of budesonide aerosol via a mesh nebulizer in a neonatal ventilator model. Design/Method In an in‐vitro ventilated neonatal model, budesonide suspension was administered using a mesh nebulizer. A collection filter was placed distal to the endotracheal tube and budesonide captured by the filter was measured using UV spectroscopy. The ventilator was, in turn, either on high frequency or conventional ventilation mode and the nebulizer was placed either proximal (close to the endotracheal tube) or distal (between the wet side of humidifier and the inspiratory circuit). Each combination (nebulizer position and ventilation mode) to assess budesonide delivery was tested five times. Results Overall delivery of budesonide to the distal end of the endotracheal tube a small percentage of the total dose administered. The deposition with conventional ventilation was 2.12% (±1.06) and 1.26% (±0.27), with proximal and distal placement of the nebulizer, respectively. With high‐frequency ventilation, the deposition percentages were 1.82% (±0.82) and 1.69% (±0.23), with proximal and distal nebulizer placement, respectively. Conclusion Only a small percentage of administered budesonide is delivered to the distal endotracheal tube, irrespective of ventilation mode, and nebulizer placement.

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