Lung flukes of the genus<i>Paragonimus</i>: ancient and re-emerging pathogens

Blair, David

doi:10.1017/s0031182022000300

Cited by 22 publications

(20 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This reflects previous findings based on molecular data, which place these 2 species in a clade with P. macrorchis and P. vietnamensis (e.g. see Blair, 2022). Unfortunately, there is no complete mtDNA sequence for P. s. skrjabini and for other related species, such as P. hokuoensis, P. macrorchis or P. vietnamensis, which could assist in the resolution of the phylogenetic position of P. s. miyazakii and P. s. skrjabini in the Paragonimidae.…”

Section: Discussionsupporting

confidence: 90%

“…The separation of Paragonimus species into 2 main groups (the P. westermani complex in one and all remaining species in the other) reflects the pattern seen using other sequence data (e.g. Blair, 2022). Similarly, the P. westermani group itself is subdivided, with the 3 Indian Type 1 mitogenomes being distinct from those from eastern Asia (and rather different from each other).…”

Section: Discussionsupporting

confidence: 69%

See 1 more Smart Citation

The complete mitogenome of the Asian lung fluke Paragonimus skrjabini miyazakii and its implications for the family Paragonimidae (Trematoda: Platyhelminthes)

Nguyen

Pham

et al. 2022

Parasitology

Self Cite

View full text Add to dashboard Cite

The complete circular mitogenome of Paragonimus skrjabini miyazakii (Platyhelminthes: Paragonimidae) from Japan, obtained by PacBio long-read sequencing, was 17 591 bp and contained 12 protein-coding genes (PCGs), 2 mitoribosomal RNA and 22 transfer RNA genes. The atp8 gene was absent, and there was a 40 bp overlap between nad4L and nad4. The long non-coding region (4.3 kb) included distinct types of long and short repeat units. The pattern of base usage for PCGs and the mtDNA coding region overall in Asian and American Paragonimus species (P. s. miyazakii, P. heterotremus, P. ohirai and P. kellicotti) and the Indian form of P. westermani was T > G > A > C. On the other hand, East-Asian P. westermani used T > G > C > A. Five Asian and American Paragonimus species and P. westermani had TTT/Phe, TTG/Leu and GTT/Val as the most frequently used codons, whereas the least-used codons were different in each species and between regional forms of P. westermani. The phylogenetic tree reconstructed from a concatenated alignment of amino acids of 12 PCGs from 36 strains/26 species/5 families of trematodes confirmed that the Paragonimidae is monophyletic, with 100% nodal support. Paragonimus skrjabini miyazakii was resolved as a sister to P. heterotremus. The P. westermani clade was clearly separate from remaining congeners. The latter clade was comprised of 2 subclades, one of the East-Asian and the other of the Indian Type 1 samples. Additional mitogenomes in the Paragonimidae are needed for genomic characterization and are useful for diagnostics, identification and genetic/ phylogenetic/ epidemiological/ evolutionary studies of the Paragonimidae.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 69%

The complete mitogenome of the Asian lung fluke Paragonimus skrjabini miyazakii and its implications for the family Paragonimidae (Trematoda: Platyhelminthes)

Nguyen

Pham

et al. 2022

Parasitology

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the next review article, Blair deals specifically with lung flukes of the genus Paragonimus (Blair, 2022). Here the lung flukes are described as enigmatic parasites that attract less attention than some other neglected tropical diseases.…”

Section: Foodborne Trematodes: the Usual Suspects And New Kids On The...mentioning

confidence: 99%

Foodborne trematodes: old foes, new kids on the block and research perspectives for control and understanding host–parasite interactions

Robinson

Sotillo

2022

Parasitology

View full text Add to dashboard Cite

Foodborne trematodes (FBTs) have a worldwide distribution (with particular prevalence in south-east Asia) and are believed to infect almost 75 million people, with millions more living at risk of infection. Although mortality due to trematodiasis is low, these infections cause considerable morbidity and some species are associated with the development of cancer in hyperendemic regions. Despite this, FBTs are often side-lined in terms of research funding and have been dubbed neglected tropical diseases by the World Health Organisation. Thus, the aim of this special issue was to provide an update of our understanding of FBT infections, to shine a light on current work in the field and to highlight some research priorities for the future. With contributions from leading researchers, many from endemic regions, we review the major FBT species. In doing so we revisit some old foes, uncover emerging infections and discover how outbreaks are being dealt with as a result of new approaches to parasite control. We also report advances in our understanding of the interactions of FBTs with their mammalian hosts and uncover new interplay between trematodes and host microbiome components. We hope that this article collection will stimulate discussion and further research on the FBTs and help raise them from their neglected status.

show abstract

“…1,2,15,16 Sputum, stool, or biopsies can determine the presence of Paragonimus eggs and distinguish paragonimiasis from other pulmonary diseases of similar presentation (e.g., tuberculosis [TB], cancer, pneumonia, bronchitis, or parapneumonic effusion). 4,5,13,17 As paragonimiasis remains a neglected tropical disease according to the WHO, 18 we sought to review the clinical manifestations, predisposing factors, and treatment of six cases identified in 2017 within the Karan hill-tribe near the Thai-Myanmar border in Umphang District, Tak Province, western Thailand.…”

Section: Introductionmentioning

confidence: 99%

Case Report: Reemerging Paragonimiasis in Umphang District, Thailand

Hanprom¹,

Lapphra

Tontiwattanasap³

et al. 2023

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Paragonimiasis is a food-born zoonotic parasitosis caused by Paragonimus spp. Six cases of reemerging paragonimiasis within the Karan hill-tribe near the Thai–Myanmar border were evaluated to review clinical manifestations, predisposing factors, and treatment regimens. All patients tested positive for paragonimiasis eggs and presented with an array of symptoms, including chronic cough, hemoptysis, peripheral eosinophilia, and thoracic radiograph abnormalities. All fully recovered after a 2- to 5-day course of 75 to 80 mg/kg/day praziquantel. We conclude that paragonimiasis should be considered during differential diagnoses to promote early treatment and to prevent misdiagnosis of reemerging or sporadic cases. This applies particularly to endemic regions and high-risk groups known to habitually consume raw or undercooked intermediate or paratenic hosts.

show abstract

Lung flukes of the genusParagonimus: ancient and re-emerging pathogens

Cited by 22 publications

References 82 publications

The complete mitogenome of the Asian lung fluke Paragonimus skrjabini miyazakii and its implications for the family Paragonimidae (Trematoda: Platyhelminthes)

The complete mitogenome of the Asian lung fluke Paragonimus skrjabini miyazakii and its implications for the family Paragonimidae (Trematoda: Platyhelminthes)

Foodborne trematodes: old foes, new kids on the block and research perspectives for control and understanding host–parasite interactions

Case Report: Reemerging Paragonimiasis in Umphang District, Thailand

Contact Info

Product

Resources

About