Lung function and biomarkers of airway inflammation during and after hospitalization for acute exacerbations of childhood asthma associated with viral respiratory symptoms

Debley, Jason S.; Cochrane, Elizabeth; Redding, Gregory J.; Carter, Edward R.

doi:10.1016/j.anai.2012.06.004

Cited by 14 publications

(18 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In acute asthma, acidification of EBC has been reported by several independent investigators [9,31,32,33]. These changes in EBC pH have also been observed in pediatric populations [10,34,35,36,37]. In this study, significant reductions in EBC pH values after SIT were observed.…”

Section: Discussionsupporting

confidence: 64%

Assessing the Efficacy of Immunotherapy with a Glutaraldehyde-Modified House Dust Mite Extract in Children by Monitoring Changes in Clinical Parameters and Inflammatory Markers in Exhaled Breath

Lozano¹,

Cruz²,

Piquer³

et al. 2014

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Introduction: The aim of this study was to evaluate the effectiveness of specific immunotherapy (SIT) management with allergoids in children with allergic asthma by monitoring changes in clinical parameters and inflammatory markers in exhaled breath. Methods: The study population included 43 patients (24 males) of 6-14 years of age, who had allergic asthma and were sensitized to mites. Twenty-three individuals were treated with subcutaneous SIT (PURETHALt Mites, HAL Allergy) for 8 months, i.e. the SIT group, and 20 were given medication to treat symptoms only, i.e. the control group. Before treatment and after 4 and 8 months, several clinical parameters, the levels of exhaled nitric oxide and the pH of exhaled breath condensate (EBC) were determined. Results: The SIT group presented with an improvement in asthma classification, a reduction in maintenance drug therapy and improved scores on the quality-of-life questionnaire. These changes were not observed in the control group. Both groups presented significant decreases in EBC pH values at 4 and 8 months after treatment compared to at baseline. However, analysis of the variable ‘ratio' showed an increase in the EBC pH values after 8 months of treatment in the SIT group compared with the values at 4 months. Conclusions: SIT with standardized mite extract reduces asthma symptoms in children. A decrease in EBC pH values was observed in both groups, although the SIT group presented a tendency of recovered values after 8 months. Future studies of EBC pH monitoring in the longer term are needed to determine the effectiveness of this marker. i 2014 S. Karger AG, Basel

show abstract

Section: Discussionsupporting

confidence: 64%

Assessing the Efficacy of Immunotherapy with a Glutaraldehyde-Modified House Dust Mite Extract in Children by Monitoring Changes in Clinical Parameters and Inflammatory Markers in Exhaled Breath

Lozano¹,

Cruz²,

Piquer³

et al. 2014

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…A previous study reported that several parameters of the pulmonary function test (PFT) usually return to their baseline values within 1-2 weeks, even after a severe asthma exacerbation,8 but in practice we witness a wide range of recovery times between administration of therapeutic agents and full recovery from asthma exacerbations. Prolonged recovery from asthma exacerbations is a high burden on the patient that can be associated with a poorer prognosis of asthma 910. However, factors associated with prolonged recovery of asthma exacerbations have not been investigated so far.…”

Section: Introductionmentioning

confidence: 99%

Factors Affecting Recovery Time of Pulmonary Function in Hospitalized Patients With Acute Asthma Exacerbations

Kim

Lee

Kim

et al. 2016

Allergy Asthma Immunol Res

View full text Add to dashboard Cite

PurposeProlonged recovery time of pulmonary function after an asthma exacerbation is a significant burden on asthmatics, and management of these patients needs to be improved. The aim of this study was to evaluate factors associated with a longer recovery time of pulmonary function among asthmatic patients hospitalized due to a severe asthma exacerbation.MethodsWe retrospectively reviewed the medical records of 89 patients who were admitted for the management of acute asthma exacerbations. The recovery time of pulmonary function was defined as the time from the date each patient initially received treatment for asthma exacerbations to the date the patient reached his or her previous best FEV1% value. We investigated the influence of various clinical and laboratory factors on the recovery time.ResultsThe median recovery time of the patients was 1.7 weeks. Multiple linear regression analysis revealed that using regular inhaled corticosteroids (ICS) before an acute exacerbation of asthma and concurrent with viral infection at admission were associated with the prolonged recovery time of pulmonary function.ConclusionsThe prolonged recovery time of pulmonary function after a severe asthma exacerbation was not shown to be directly associated with poor adherence to ICS. Therefore the results indicate that an unknown subtype of asthma may be associated with the prolonged recovery of pulmonary function time after an acute exacerbation of asthma despite regular ICS use. Further prospective studies to investigate factors affecting the recovery time of pulmonary function after an asthma exacerbation are warranted.

show abstract

“…6,7,19 Eicosanoids are inflammatory mediators implicated in the pathogenesis of both allergic asthma and sickle cell lung disease. [20][21][22] While eicosanoid levels have been analyzed in the exhaled breath condensate (EBC) of children with asthma, [23][24][25][26] this has not been done in children with SCD.…”

Section: Introductionmentioning

confidence: 99%

Airway hyperreactivity is frequent in non-asthmatic children with sickle cell disease

et al. 2015

View full text Add to dashboard Cite

show abstract

Lung function and biomarkers of airway inflammation during and after hospitalization for acute exacerbations of childhood asthma associated with viral respiratory symptoms

Cited by 14 publications

References 29 publications

Assessing the Efficacy of Immunotherapy with a Glutaraldehyde-Modified House Dust Mite Extract in Children by Monitoring Changes in Clinical Parameters and Inflammatory Markers in Exhaled Breath

Assessing the Efficacy of Immunotherapy with a Glutaraldehyde-Modified House Dust Mite Extract in Children by Monitoring Changes in Clinical Parameters and Inflammatory Markers in Exhaled Breath

Factors Affecting Recovery Time of Pulmonary Function in Hospitalized Patients With Acute Asthma Exacerbations

Airway hyperreactivity is frequent in non-asthmatic children with sickle cell disease

Contact Info

Product

Resources

About