Lung function and blood levels of copper, selenium, vitamin C and vitamin E in the general population

Pearson, Philip J; Britton, John; McKeever, Tricia M.; Lewis, Sarah; Weiss, Scott T.; Pavord, Ian D.; Fogarty, Andrew

doi:10.1038/sj.ejcn.1602209

Cited by 43 publications

(38 citation statements)

References 39 publications

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“…Another study found that lower respiratory function and higher serum copper concentration were associated [7]. Similar to this study, our study found that serum copper levels and lung function are associated.…”

Section: Discussionsupporting

confidence: 91%

Interstitial Lung Disease in Coppersmiths in High Serum Copper Levels

Dagli

Tanrıkulu

Köksal

et al. 2009

Biol Trace Elem Res

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Coppersmith is a worker who uses copper most commonly for the production of kitchen appliances in Turkey. This is an ancient occupation practiced for centuries in Turkey. Our objective was to investigate the prevalence of parenchymal lung diseases among coppersmiths in Kahramanmaras city in Turkey. Thirty coppersmiths were included to the study, and they all signed an informed consent. Demographics, spirometric test results and high-resolution computed tomography (HRCT) scans, and blood samples were obtained. Laboratory analysis of the serum samples showed that serum copper levels of the subjects were 0.93 +/- 0.14 mg/L. Serum copper level in control group was found as 0.70 +/- 0.14 mg/L, and it was significantly different between the two groups (p < 0.05). Of 30 coppersmiths, 17 HRCT findings are abnormal and seen with diffuse parenchymal interstitial lung disease pattern-ten (58.8%) respiratory bronchiolitis interstitial lung disease, five (29.4%) nonspecific interstitial pneumonia, and two (11.8%) usual interstitial pneumonia. The most prevalent HRCT pattern was micronodular pattern in workers. This is the first field study reporting the radiologic findings of coppersmiths and effect of the occupation on lung diseases.

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Section: Discussionsupporting

confidence: 91%

Interstitial Lung Disease in Coppersmiths in High Serum Copper Levels

Dagli

Tanrıkulu

Köksal

et al. 2009

Biol Trace Elem Res

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“…For example, higher serum Se levels are positively associated with higher FEV1 and are protective for lung function [3,4]. In addition, several epidemiological studies have observed lowered serum Se levels in asthma patients [5][6][7][8], yet the level of Se deficiency that is associated with asthma is not clearly established.…”

Section: Introductionmentioning

confidence: 99%

Selenium deficiency alters epithelial cell morphology and responses to influenza

Jaspers

Zhang

Brighton

et al. 2007

Free Radical Biology and Medicine

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It is unknown whether nutritional deficiencies affect the morphology and function of structural cells, such as epithelial cells, and modify the susceptibility to viral infections. We developed an in vitro system of differentiated human bronchial epithelial cells (BEC) grown either under selenium adequate (Se+) or selenium deficient (Se-) conditions, to determine whether selenium deficiency impairs host defense responses at the level of the epithelium. Se-BECs had normal SOD activity, but decreased activity of the selenium-dependent enzyme GPX1. Interestingly, catalase activity was also decreased in Se-BECs. Both Se-and Se+ BECs differentiated into a mucociliary epithelium; however, Se-BEC demonstrated increased mucus production and increased Muc5AC mRNA levels. This effect was also seen in Se+ BEC treated with 3-aminotriazole, and inhibitor of catalase activity, suggesting an association between catalase activity and mucus production. Both Se-and Se+ were infected with influenza A/Bangkok/1/79 and examined 24 hours post-infection. Influenza-induced IL-6 production was greater while influenza-induced IP-10 production was lower in Se-BECs. In addition, influenza-induced apoptosis was greater in Se-BEC as compared to the Se+ BECs. These data demonstrate that selenium deficiency has a significant impact on the morphology and influenzainduced host defense responses in human airway epithelial cells.

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“…It has also been suggested that serum Se, another antioxidant, may have pulmonary protective effects but its reported associations with pulmonary function are based on a limited number of studies (11,15) .…”

mentioning

confidence: 99%

Dietary and supplemental antioxidant and anti-inflammatory nutrient intakes and pulmonary function

Niti

Yap

et al. 2013

Public Health Nutr.

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Objective: A limited but growing body of evidence supports a significant role of antioxidant and anti-inflammatory micronutrients in pulmonary health. We investigated the associations of dietary and supplemental intakes of vitamins A, C, E and D, Se and n-3 PUFA with pulmonary function in a population-based study. Design: Population-based, cross-sectional study and data analysis of fruits and vegetables, dairy products and fish, vitamins A, C, E and D, Se and n-3 PUFA supplemental intakes, pulmonary risk factors and spirometry. Subjects: Chinese older adults (n 2478) aged 55 years and above in the Singapore Longitudinal Ageing Studies. Results: In multiple regression models that controlled simultaneously for gender, age, height, smoking, occupational exposure and history of asthma/chronic obstructive pulmonary disease, BMI, physical activity, and in the presence of other nutrient variables, daily supplementary vitamins A/C/E (b 5 0?044, SE 5 0?022, P 5 0?04), dietary fish intake at least thrice weekly (b 5 0?058, SE 5 0?016, P , 0?0001) and daily supplementary n-3 PUFA (b 5 0?068, SE 5 0?032, P 5 0?034) were individually associated with forced expiratory volume in the first second. Supplemental n-3 PUFA was also positively associated with forced vital capacity (b 5 0?091, SE 5 0?045, P 5 0?045). No significant association with daily dairy product intake, vitamin D or Se supplements was observed. Conclusions: The findings support the roles of antioxidant vitamins and n-3 PUFA in the pulmonary health of older persons.

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Lung function and blood levels of copper, selenium, vitamin C and vitamin E in the general population

Cited by 43 publications

References 39 publications

Interstitial Lung Disease in Coppersmiths in High Serum Copper Levels

Interstitial Lung Disease in Coppersmiths in High Serum Copper Levels

Selenium deficiency alters epithelial cell morphology and responses to influenza

Dietary and supplemental antioxidant and anti-inflammatory nutrient intakes and pulmonary function

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