Lung function and cognitive ability in children: a UK birth cohort study

Grenville, Jack; Granell, Raquel; Dodd, James

doi:10.1136/bmjresp-2022-001528

Cited by 6 publications

(1 citation statement)

References 37 publications

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“…In the current study, we incorporated the general intelligence score variable as part of our analysis, given that several previous studies have demonstrated an association between intelligence and lung function (Taylor et al 2005;Suglia et al 2008;Vasilopoulos et al 2015;Grenville et…”

Section: Ozone Exposure Assessment Metricsmentioning

confidence: 99%

Evaluating the effect of long-term exposure to ozone on lung function by different metrics

Raz-Maman,

Borochov-Greenberg,

Lefkowitz

et al. 2024

Air Qual Atmos Health

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Background The majority of studies examining long-term exposure to ambient ozone have utilized averages as the exposure parameter. However, averaging ozone exposures may underestimate the impact of ozone peaks and seasonality. The current study aimed to examine the association between ozone exposure evaluated by different exposure metrics and lung function in healthy adolescents. Methods We conducted a cross-sectional study among 665 healthy adolescent males living within a 2 km radius of an ozone monitoring station. Multiple ozone exposure metrics were evaluated, including two-year and peak-season averages, peaks, peak intensity, and the total excess of peak level. Lung function was measured using FEV1, FVC, and FEV1/FVC ratio. Results The peak intensity during the ozone peak-season was associated with the largest decrease in the FEV1/FVC ratio, -1.52% (95%CI: -2.55%, -0.49%) (p < 0.01). Concurrently, we did not observe a significant association between ozone exposure, assessed by different metrics, and either FEV1 or FVC. Conclusions The study findings suggest that when evaluating ambient ozone exposures, ozone peak intensity during peak-season should be considered, as it may predict greater adverse health effects than averages alone.

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Section: Ozone Exposure Assessment Metricsmentioning

confidence: 99%

Evaluating the effect of long-term exposure to ozone on lung function by different metrics

Raz-Maman,

Borochov-Greenberg,

Lefkowitz

et al. 2024

Air Qual Atmos Health

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Extended long‐term efficacy and safety of velmanase alfa treatment up to 12 years in patients with alpha‐mannosidosis

Guffon,

Borgwardt,

Tylki‐Szymańska

et al. 2024

J of Inher Metab Disea

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Enzyme replacement therapy (ERT) using velmanase alfa previously showed promising efficacy and safety outcomes for up to 4 years of therapy in patients with alpha‐mannosidosis. This pooled analysis from two multicenter, open‐label phase IIIb extension trials rhLAMAN‐07 (N = 13; NCT01908712) and rhLAMAN‐09 (N = 8; NCT01908725) evaluated the long‐term effects of velmanase alfa. Sixteen patients who previously completed phase I–III rhLAMAN‐02/‐03/‐04/‐05/‐08 trials and five ERT‐naïve patients were enrolled. Patients received 1 mg/kg velmanase alfa once weekly. Endpoints included changes from treatment baseline (before initial dose of velmanase alfa in any trial) in serum oligosaccharides, 6‐minute walk test (6MWT), 3‐minute stair climb test (3MSCT), pulmonary function (forced vital capacity [FVC], % predicted), serum immunoglobulin G (IgG) levels, and adverse events. The overall cohort comprised 21 patients, divided by age at treatment baseline into pediatric (n = 14) and adult subgroups (n = 7). Distance walked according to 6MWT increased or stabilized in pediatric patients, while in adults either stabilization or slight decline was observed. Similarly, pediatric patients performed better in the 3MSCT. Changes in FVC, % predicted, were comparable in both subgroups up to ~6 years of observation, diverging thereafter. Overall, sustained serum oligosaccharide clearance and serum IgG level increase was observed upon treatment initiation and persisted until last common observation. Velmanase alfa treatment was generally well tolerated, with the majority of reported adverse events being of mild‐to‐moderate intensity. With follow‐up of up to 12 years, long‐term efficacy and safety outcomes indicate continued benefits of velmanase alfa in patients with alpha‐mannosidosis.

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Lung development genes, adult lung function and cognitive traits

Talaei,

Waters,

Portas

et al. 2024

Brain Communications

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Lower lung function is associated with lower cognitive function and an increased risk of dementia. This has not been adequately explained and may partly reflect shared developmental pathways. In UK Biobank participants of European ancestry, we tested the association between lung function measures (forced vital capacity and forced expiratory volume in one second to forced vital capacity ratio; N=306,476) and cognitive traits including nine cognitive function test scores (N=32,321-428,609), all-cause dementia, Alzheimer’s disease, and vascular dementia (6,805, 2,859 and 1,544 cases, respectively, and ∼421,241 controls). In the same population, we derived summary statistics for associations between common genetic variants in 55 lung development genes, and lung function measures and cognitive traits using adjusted linear/logistic regression models. Using a hypothesis-driven Bayesian colocalisation analysis, we finally investigated the presence of shared genetic signals between lung function measures and cognitive traits at each of these 55 genes. Higher lung function measures were generally associated with higher scores of cognitive function tests as well as lower risk of dementia, with the strongest association between forced vital capacity and vascular dementia. The strongest association was between forced vital capacity and vascular dementia (adjusted hazard ratio 0.74 per standard deviation increase, 95% CI 0.67-0.83). Of the 55 genes of interest, we found shared variants in four genes, namely: CSNK2B rs9267531 (forced vital capacity and forced expiratory volume in one second to forced vital capacity ratio with fluid intelligence and pairs matching); NFATC3 rs548092276 & rs11275011 (forced expiratory volume in one second to forced vital capacity ratio with fluid intelligence); PTCH1 rs2297086 & rs539078574 (forced expiratory volume in one second to forced vital capacity ratio with reaction time); and KAT8 rs138259061 (forced vital capacity with pairs matching). However, the direction of effects was not in keeping with our hypothesis, i.e. variants associated with lower lung function were associated with better cognitive function or vice versa. We also found distinct variants associated with lung function and cognitive function in KAT8 (forced vital capacity and Alzheimer’s disease) and PTCH1 (forced vital capacity and forced expiratory volume in one second to forced vital capacity ratio with fluid intelligence and reaction time). The links between CSNK2B and NFATC3 and cognitive traits have not been previously reported by genome-wide association studies. Despite shared genes and variants, our findings do not support the hypothesis that shared developmental signalling pathways explain the association of lower adult lung function with poorer cognitive function.

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Lung function and cognitive ability in children: a UK birth cohort study

Cited by 6 publications

References 37 publications

Evaluating the effect of long-term exposure to ozone on lung function by different metrics

Evaluating the effect of long-term exposure to ozone on lung function by different metrics

Extended long‐term efficacy and safety of velmanase alfa treatment up to 12 years in patients with alpha‐mannosidosis

Lung development genes, adult lung function and cognitive traits

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