Lung function by impulse oscillometry at age 5–7 years after bronchiolitis at age 0–6 months

Abstract

Though reduced lung function and increased airway reactivity were rather common, evidence for persistent lung function reduction was rare, less than 1%, at preschool age in children hospitalized for bronchiolitis caused mainly by respiratory syncytial virus at age less than 6 months.

The Burden and Long-term Respiratory Morbidity Associated with Respiratory Syncytial Virus Infection in Early Childhood

“…However, in contrast to the previous studies, a Finnish study indicated a potentially more restrictive pattern of lung function abnormality, documented by significantly decreased FVC values concomitantly with normal FEV 1 values and even elevated FEV 1 /FVC values [64]. Finally, another recent study from Finland observed that less than 1% of 5- to 7-year-old children, hospitalized for bronchiolitis caused mainly by RSV at age <6 months, had persistent lung function reduction [65]. …”

Respiratory reactance in children aged three to five years with postinfectious bronchiolitis obliterans is higher than in those with asthma

“…On the basis of our present study, which did not demonstrate BDR in respiratory resistance, but in respiratory reactance in children with PIBO, assessment of forced expiratory volume in one-second may have limitation for the detection of BDR, especially in small airways. Although there have been studies on followup in children with PIBO using spirometry and children with a history of bronchiolitis in early infancy using IOS (29,30), studies on the change of lung function using IOS during follow-up in children with PIBO are lacking. However, the levels of Xrs5 in children with PIBO did not still reach those in the nonatopic control and asthmatic groups even after the administration of a bronchodilator.…”

Following up infant bronchiolitis patients provided new evidence for and against the united airway disease hypothesis

“…The age criterion for bronchiolitis in these studies was less than 12 months. Our patients were hospitalised at less than six months of age and RSV caused 70% of all the cases in infancy and 60% of those who completed the follow‐up period . Thus, former non‐RSV bronchiolitis patients were more likely to take part in our study than former RSV bronchiolitis patients, and that might have been reflected in our high numbers of allergic rhinitis and atopy.…”

“…Complete IOS measurements, at baseline and after the exercise challenge test (ECT), and bronchodilation (BD) tests were available for 103 of these 127 children, as previously published . One child with no history of prolonged rhinitis or asthma refused to undergo the SPT.…”

“…Lung function, as measured by impulse oscillometry (IOS), showed small airways obstruction in the baseline measurements, with 20% of these being abnormal when compared to Finnish population data. The data also showed that 16% had bronchial hyper‐reactivity (BHR) .…”