Lung function impairment in relation to asbestos-induced pleural lesions with reference to the extent of the lesions and the initial parenchymal fibrosis

Lebedová, Jindřiška; Dlouha, Beatrica; Rychla, Lenka; Neuwirth, J; Brabec, Marek; Pelclová, Daniela; Fenclová, Zdeňka

doi:10.5271/sjweh.745

Cited by 13 publications

(7 citation statements)

References 22 publications

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“…Reduced lung function was not only associated with parenchymal changes on X-ray, considered essential for the clinical diagnosis of lung Wbrosis (Becklake 1991), but also with pleural thickening of all stages, which was associated with the largest loss of FVC and FEV1. Although the latter Wnding was not conWrmed in some other studies (Piirila et al 2005;Van Cleemput et al 2001) (based on high-resolution computed tomography) it was quite pronounced in this Austrian cohort and has also been reported elsewhere (Petrovic et al 2004;Lebedova et al 2003). In contrast to pleural plaques diVuse pleural thickening had also been associated with increased risk of cancer (Neuberger 1989), however, lung cancer in our cohort was predicted best by smoking, age and Wbre years.…”

Section: Discussioncontrasting

confidence: 44%

Lung function predicts survival in a cohort of asbestos cement workers

Moshammer

Neuberger

2008

Int Arch Occup Environ Health

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Lung function decrease predicts risk of premature death better than exposure history and regular spirometry should therefore be offered as primary screening to all former asbestos workers. In workers with a history of high cumulative exposure or rapid lung function decrease or radiological signs (diffuse pleural thickening or small irregular opacities) more sensitive techniques (high resolution computer tomography) need to be applied. All smokers with a history of asbestos exposure should be given free smoking cessation therapy to prevent premature death and lung cancer in particular.

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Section: Discussioncontrasting

confidence: 44%

Lung function predicts survival in a cohort of asbestos cement workers

Moshammer

Neuberger

2008

Int Arch Occup Environ Health

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“…A positive relationship between the severity of functional impairment and the radiologically defined degree (score) of asbestos-related pleural and/or pulmonary fibrosis was already reported in a few studies [32-34]. As shown the absence of characteristic radiological findings does not exclude lung function abnormalities.…”

Section: Discussionmentioning

confidence: 95%

Lung function in asbestos-exposed workers, a systematic review and meta-analysis

Wilken

Garrido

Manuwald

et al. 2011

J Occup Med Toxicol

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BackgroundA continuing controversy exists about whether, asbestos exposure is associated with significant lung function impairments when major radiological abnormalities are lacking. We conducted a systematic review and meta-analysis in order to assess whether asbestos exposure is related to impairment of lung function parameters independently of the radiological findings.MethodsMEDLINE was searched from its inception up to April 2010. We included studies that assessed lung function parameters in asbestos exposed workers and stratified subjects according to radiological findings. Estimates of VC, FEV1 and FEV1/VC with their dispersion measures were extracted and pooled.ResultsOur meta-analysis with data from 9,921 workers exposed to asbestos demonstrates a statistically significant reduction in VC, FEV1 and FEV1/VC, even in those workers without radiological changes. Less severe lung function impairments are detected if the diagnoses are based on (high resolution) computed tomography rather than the less sensitive X-ray images. The degree of lung function impairment was partly related to the proportion of smokers included in the studies.ConclusionsAsbestos exposure is related to restrictive and obstructive lung function impairment. Even in the absence of radiological evidence of parenchymal or pleural diseases there is a trend for functional impairment.

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“…Compared to the chest roentgenogram, an HRCT scan is a more sensitive method for detecting parenchymal lesions. In some studies, 27-46% of patients without parenchymal lesions by chest roentgenogram have been found to have parenchymal lesion with HRCT [34,35]. However, the ILO classification is still widely used for the evaluation of lung parenchyma.…”

Section: Discussionmentioning

confidence: 98%

Relationships Between Respiratory Function Disorders and Serum Copper Levels in Copper Mineworkers

Abakay

Gökalp

Abakay³

et al. 2011

Biol Trace Elem Res

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The aim of this study was to investigate the respiratory function disorders that could be related to dust exposure during the production of copper mine in copper mineworkers (CMWs). The study included 75 male CMWs (mean age, 32.0 ± 7.1 years, 58.6% smokers) and 75 male age- and smoking status-matched healthy control subjects. Serum Cu level was significantly higher in the CMW group (0.80 ± 0.62 μg/ml) than the control group (0.60 ± 0.39 μg/ml) (p = 0.017). Significant negative correlations were found between serum Cu level and forced expiratory volume in first second (r = -0.600; p < 0.001) and between serum Cu level and forced vital capacity (r = -0.593; p = <0.001) in CMWs. Serum Cu level was significantly higher in the restrictive type pulmonary function disorders group (1.36 ± 0.62 μg/ml) than obstructive type (0.90 ± 0.55 μg/ml) and normal pulmonary function pattern group (0.53 ± 0.43 μg/ml) (p < 0.001). Patients with radiological parenchymal abnormalities had significantly higher serum copper levels than those without abnormalities (1.53 ± 0.52 vs. 0.71 ± 0.52 μg/ml, respectively; p = 0.002). In conclusion, result of the study has shown a negative association between pulmonary functions disorders and radiological abnormalities and serum Cu levels in CMWs.

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Lung function impairment in relation to asbestos-induced pleural lesions with reference to the extent of the lesions and the initial parenchymal fibrosis

Cited by 13 publications

References 22 publications

Lung function predicts survival in a cohort of asbestos cement workers

Lung function predicts survival in a cohort of asbestos cement workers

Lung function in asbestos-exposed workers, a systematic review and meta-analysis

Relationships Between Respiratory Function Disorders and Serum Copper Levels in Copper Mineworkers

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