Lung Function in Congenital Heart Disease

Linde, Leonard M.; Siegel, Sidney I.; Martelle, Robert R.; Simmons, Daniel H.

doi:10.1378/chest.46.1.46

Cited by 6 publications

(1 citation statement)

References 18 publications

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“…Leonard M et al found that children with severe PAH associated with CHD presented significant reduction in FVC. 11 Our study confirmed that restrictive pattern is the most striking characteristic of pulmonary function test, followed by the obstructive pattern. These findings are in agreement with the study of Sabry AF et al 4 The restrictive pattern, characterized by severely decreased FVC, is due to the lung stiffness and to the reduced lung compliance secondary to increased pul- monary pressure.…”

Section: Discussionsupporting

confidence: 85%

A Correlative Study of Spirometric Parameters and Markers of Right Ventricular Dysfunction in Pediatric Patients with Pulmonary Arterial Hypertension

Şuteu

Muntean

Blesneac

et al. 2016

Journal of Interdisciplinary Medicine

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Background: Alteration in lung function is present in children with pulmonary arterial hypertension (PAH). We aimed to study the pulmonary function indices obtained by spirometry in pediatric patients with PAH, and to correlate them with B-type natriuretic peptide (BNP) and echocardiographic parameters. Methods: Thirty-one children with PAH were enrolled in this study, of those 26 patients (83.87%) associated shunt defect and 5 patients (16.12%) were diagnosed with idiopathic PAH. Forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC, peak expiratory flow rate (PEFR), forced expiratory flow at 25–75% of the pulmonary volume (FEF 25–75) were evaluated by spirometry and correlated with BNP and echocardiographic parameters that reflect right ventricle function. Results: Restrictive pattern of pulmonary function was present in 51.6% (n = 16) of all PAH children. There were significant correlations between BNP with FVC (p = 0.001), FEV1 (p = 0.001), and FEV1/FVC (p = 0.001). Serum BNP level was significantly increased in the group of patients without shunt. Of those echocardiographic parameters that reflect right ventricle function, we found that TAPSE significantly correlated with PEFR (r = −0.47, p <0.01), and with FEF 25–75 (r = −0.39, p <0.01). Conclusions: Deterioration of the pulmonary function indices are correlated with BNP and echocardiographic parameters, markers of RV dysfunction. Being easy and reliable tests, pulmonary functions can be introduced among the follow-up tools in children with PAH.

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Section: Discussionsupporting

confidence: 85%