Lung function in white children aged 4 to 19 years: I--Spirometry.

Rosenthal, Mark; Bain, S H; Cramer, Derek; Helms, Peter Joseph Benedict; Denison, D M; Bush, Andy; Warner, J O

doi:10.1136/thx.48.8.794

Cited by 238 publications

(215 citation statements)

References 13 publications

Supporting

Mentioning

196

Contrasting

Unclassified

Order By: Relevance

“…Eighteen variables were analysed. FEV1, forced vital capacity (FVC), and peak expiratory flow rate (PEFR) were measured by a Vitalograph Compact spirometer (Vitalograph, Buckinghamshire, UK) using Brompton Predicted scores to correct for height [5]. Minimum oxygen saturation during a 12-min walk (Sa,O 2 min) [6] was measured by continuous pulse oximetry.…”

Section: Methodsmentioning

confidence: 99%

A model for predicting life expectancy of children with cystic fibrosis

Aurora

Wade²,

Whitmore

et al. 2000

Eur Respir J

View full text Add to dashboard Cite

In this study the authors aimed to produce a model for predicting the life expectancy of children with severe cystic fibrosis (CF) lung disease.The survival of 181 children with severe CF lung disease referred for transplantation assessment 1988±1998 (mean age 11.5 yrs, median survival without transplant 1.9 yrs from date of assessment) were studied. Proportional hazards modelling was used to identify assessment measurements that are of value in predicting longevity.The resultant model included low height predicted forced expiratory volume in one second (FEV1), low minimum oxygen saturation (Sa,O 2 min) during a 12-min walk, high age adjusted resting heart rate, young age, female sex, low plasma albumin, and low blood haemoglobin as predictors for poor prognosis. Extrapolation from the model suggests that a 12-yr old male child with an FEV1 of 30% pred and a Sa,O 2 min of 85% has a 44% risk of death within 2 yrs (95% confidence interval (CI) 35±54%), whilst a female child with the same measurements has a 63% risk of death (95% CI 52±73%) within the same period.The model produced may be of value in predicting the life expectancy of children with severe cystic fibrosis lung disease and in optimizing the timing of lung transplantation.

show abstract

Section: Methodsmentioning

confidence: 99%

A model for predicting life expectancy of children with cystic fibrosis

Aurora

Wade²,

Whitmore

et al. 2000

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…Pretransplant FEV1 (FEV1t) was measured by spirometry, and corrected for height, age and sex using Brompton predicted scores [10]. Pretransplant minimum oxygen saturation obtained during a 12-min walk (Sa,O 2 mint) [11] was measured by continuous pulse oximetry.…”

Section: Methodsmentioning

confidence: 99%

The effect of prelung transplant clinical status on post-transplant survival of children with cystic fibrosis

Aurora¹,

Gassas²,

Ehtisham³

et al. 2000

Eur Respir J

View full text Add to dashboard Cite

The aim of this study was to determine whether transplanting paediatric cystic fibrosis (CF) patients later in the course of their disease was detrimental to their post‐transplant survival. Data was collected from 51 children with CF undergoing lung or heart‐lung transplantation May 1988–March 1999. The following risk factors were tested by Cox proportional hazards modelling: age at transplant; sex; donor/recipient sex mismatch; donor/recipient cytomegalovirus (CMV) mismatch; cold and warm graft ischaemic times; and donor age. Pretran‐splant forced expiratory volume in one second (FEV1), minimum oxygen saturation obtained during 12 min walk (Sa,O2min), and a survival probability score (SP) calculated from FEV1, age adjusted resting heart rate, age, sex, blood haemoglobin (Hb), and serum albumin were then added to the model. None of the risk factors were significantly correlated with death during the study period. No evidence that clinical status prior to transplant has any effect upon the post‐transplant survival of children with cystic fibrosis was found.

show abstract

“…23 Boys at this age tend to have higher IgE concentrations than girls, 19 in addition to lower respiratory fl ow rates. 10,17 Asthma management conditions in Brazil are below what is ideal. Considering the fact that asthma is a disease sensitive to primary health care management, hospitalizations are viewed as inevitable.…”

Section: Discussionmentioning

confidence: 99%