Lung Function Testing and Prediction Equations in Adult Population from Maputo, Mozambique

Abstract

Background: Local spirometric prediction equations are of great importance for interpreting lung function results and deciding on the management strategies for respiratory patients, yet available data from African countries are scarce. The aim of this study was to collect lung function data using spirometry in healthy adults living in Maputo, Mozambique and to derive first spirometric prediction equations for this population. Methods: We applied a cross-sectional study design. Participants, who met the inclusion criteria, underwent a short interview, anthropometric measurements, and lung function testing. Different modelling approaches were followed for generating new, Mozambican, prediction equations and for comparison with the Global Lung Initiative (GLI) and South African equations. The pulmonary function performance of participants was assessed against the different reference standards. Results: A total of 212 males and females were recruited, from whom 155 usable spirometry results were obtained. The mean age of participants was 35.20 years (SD 10.99) and 93 of 155 (59.35%) were females. The predicted values for forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and the FEV1/FVC ratio based on the Mozambican equations were lower than the South African—and the GLI-based predictions. Conclusions: This study provides first data on pulmonary function in healthy Mozambican adults and describes how they compare to GLI and South African reference values for spirometry.

Spirometry Profiles Among Pregnant And Non-Pregnant African Women

“…We report mean spirometry test values in pregnant women which are lower than the means reported in Brazilians (20). The non-pregnant means of FVC, FEV1, PEF and their % predicted in this study are comparable to values reported from other studies done in Tanzania (29), Rwanda (30) and Mozambique (31). Our values were slightly higher than the other studies because of the age difference as the mean age of non-pregnant women was less than 30 years in this while it was more than 35 in the other studies.…”

“…Furthermore, there is a lack of reference values for spirometry parameters and their associated factors among pregnant in Sub Saharan Africa including Tanzania. Few studies available only involved non-pregnant African women (29)(30)(31). Therefore, the test results among pregnant women are compared against the general population reference values.…”

Post-tuberculosis lung impairment: systematic review and meta-analysis of spirometry data from 14 621 people

“…Apart from differences in study design, there could be other sources for the heterogeneity observed in our data. For instance, the use of inadequate reference standards or diagnostic thresholds, especially for study populations that are not represented by common standards like the Global Lung Function Initiative, could lead to over- or under-reporting of lung impairment [ 13 , 86 , 87 ]. In addition, there was an indication for a systematic under-reporting of restriction or mixed impairment types within the reviewed studies.…”

Normal Spirometry Prediction Equations for the Iranian population

“…But this amount was estimated at 10% in Mozambique's reference population (Southeast Africa (. 23 , also the LLNs of FEV 1 /FVC were less than 0.70 in men above 56 years of age and women above years of age in Chinese aged 4-80 years. 1 Concerning the high prevalence in men over 70 years of age, this may be due to the low sample size in this age group (16 people).…”