Lung Function Variability in Children and Adolescents With and Without Asthma (LUV Study): Protocol for a Prospective, Nonrandomized, Clinical Trial

Frima, Eirini-Sofia; Theodorakopoulos, Ilias; Gidaris, Dimos; Karantaglis, Nikolaos; Chatziparasidis, Grigorios; Plotas, Panagiotis; Anthracopoulos, Michael B.; Fouzas, Sotirios

doi:10.2196/20350

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Therefore, identifying early diagnostic biomarkers and tools that will improve the monitoring of airway dysfunction and inflammation through non-invasive methods are key goals in successful pediatric asthma management. Currently, there is increasing attention on the development of methodologies that permit the close monitoring of disease-associated lung function changes [ 5 ] and the identification of novel biomarkers that will predict asthma progression on a molecular level. It is believed that asthma is driven by the interaction between genes and environmental factors, including nutrition, air pollution, and cigarette smoke, pet hair, viral infections, weather changes, dust mites, dampness, mold and high body weight [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Application of Metabolomics in Pediatric Asthma: Prediction, Diagnosis and Personalized Treatment

et al. 2021

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Asthma in children remains a significant public health challenge affecting 5–20% of children in Europe and is associated with increased morbidity and societal healthcare costs. The high variation in asthma incidence among countries may be attributed to differences in genetic susceptibility and environmental factors. This respiratory disorder is described as a heterogeneous syndrome of multiple clinical manifestations (phenotypes) with varying degrees of severity and airway hyper-responsiveness, which is based on patient symptoms, lung function and response to pharmacotherapy. However, an accurate diagnosis is often difficult due to diversities in clinical presentation. Therefore, identifying early diagnostic biomarkers and improving the monitoring of airway dysfunction and inflammatory through non-invasive methods are key goals in successful pediatric asthma management. Given that asthma is caused by the interaction between genes and environmental factors, an emerging approach, metabolomics—the systematic analysis of small molecules—can provide more insight into asthma pathophysiological mechanisms, enable the identification of early biomarkers and targeted personalized therapies, thus reducing disease burden and societal cost. The purpose of this review is to present evidence on the utility of metabolomics in pediatric asthma through the analysis of intermediate metabolites of biochemical pathways that involve carbohydrates, amino acids, lipids, organic acids and nucleotides and discuss their potential application in clinical practice. Also, current challenges on the integration of metabolomics in pediatric asthma management and needed next steps are critically discussed.

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Section: Introductionmentioning

confidence: 99%

Application of Metabolomics in Pediatric Asthma: Prediction, Diagnosis and Personalized Treatment

et al. 2021

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“…All had interrupted their controller medication for at least four weeks prior to CPET. Healthy controls were recruited from local public schools; 16 they all had normal spirometry and no asthma diagnosis or prescription of relevant medication within the last two years. All participants had normal echocardiographic examination on the day of enrolment.…”

Section: Methodsmentioning

confidence: 99%

Exercise Limitation in Children and Adolescents with Mild-to-Moderate Asthma

Λάγιου¹,

Fouzas²,

Lykouras³

et al. 2022

JAA

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Background Children with uncontrolled asthma are less tolerant to exercise due to ventilatory limitation, exercise-induced bronchoconstriction (EIB), or physical deconditioning. The contribution of these factors in children with controlled mild-to-moderate asthma is unknown. Objective To explore the underlying mechanisms of reduced exercise capacity in children with controlled mild-to-moderate asthma. Methods This was a cross-sectional study of 45 children and adolescents (age 8–18 years) with controlled mild-to-moderate asthma (asthma control test score 21–25) and 61 age-matched healthy controls. All participants completed a physical activity questionnaire and performed spirometry and cardiopulmonary exercise testing (CPET; maximal incremental protocol). Spirometric indices and CPET parameters were compared between the two groups. The effect of EIB (FEV 1 decrease >10% post CPET), ventilatory limitation and physical deconditioning on maximum oxygen uptake ( O 2 peak), was assessed by multivariable linear regression. Results 62.2% of children with asthma and 29.5% of controls (P = 0.002) were categorized as inactive. Reduced exercise capacity ( O 2 peak <80%) was noted in 53.3% of asthmatics and 16.4% of controls (P < 0.001). EIB was documented in 11.1% of participants with asthma. Physical deconditioning was noted in 37.8% of children with asthma and in 14.8% of controls (P = 0.013). Physical deconditioning emerged as the only significant determinant of O 2 peak, irrespective of asthma diagnosis, body mass index, ventilatory limitation and EIB. Conclusion Children with controlled mild-to-moderate asthma are less tolerant to strenuous exercise than their healthy peers. The decreased exercise capacity in this population should mainly be attributed to physical deconditioning, while the contribution of ventilatory limitation and EIB is rather small.

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“…Advances in digital technologies have led to the development of dramatically smaller oscillometry devices equipped with internal data storage and internet access for remote data transfer suitable for self-administered home monitoring (150,151). Increased variability of airway function is a hallmark feature of asthma in general and particularly so at the onset of an acute exacerbation in some individuals (152)(153)(154)(155). In a study of 10 nonsmoking patients with mild asthma, Gobbi et al…”

Section: Recent Applications Of Oscillometrymentioning

confidence: 99%

Oscillometry to Assess Respiratory Function in Adult Cystic Fibrosis

Rad

Landry

Dong

et al. 2020

B30. Arthur Dubois Memorial Session: The Small and Large of Airway and Lung Function

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Oscillometry to Assess Respiratory Function in Adult Cystic FibrosisBackground and Rationale: Cystic fibrosis (CF) is a life-limiting multi-system disorder in which respiratory dysfunction predominates. Although spirometry is the most commonly used test of pulmonary function, it has recognized limitations. Oscillometry is an alternative test of respiratory function which provides complementary information. Oscillometry also offers a number of practical and physiological advantages and is increasingly used in both clinical research and patient care. Surprisingly, little data exists using oscillometry to evaluate lung function in adults with CF.Accordingly, the aim of this study was to compare spirometry and oscillometry in a large adult CF cohort. Methods: Spirometry and oscillometry (tremoFlo® C-100, Thorasys Thoracic Medical Systems Inc., Montreal, Canada) were performed according to published guidelines during a routine visit to the Montreal Chest Institute Adult CF Clinic, McGill University Health Centre in 92 adults with established CF in stable state (mean age = 33.0 ± SE 1.3 yrs, 51 men). Oscillometry parameters included respiratory resistance at 5 Hz (R5), the difference in respiratory resistance at 5 and 20 Hz (R5-20), respiratory reactance at 5 Hz (X5), respiratory reactance area (AX), and resonant frequency (Fres).Results: Respiratory function was significantly reduced for the group (forced expiratory volume in one second, FEV1 = 2.27 ± SE 0.1 L; Z score = -3.38 ± SE 0.23). There was generally a good to strong correlation between spirometry and oscillometry parameters, particularly between FEV1 and both X5 and AX, and all relationships were highly significant (P < 0.001). Results were generally similar when expressed as absolute values or Z scores. Logistic regression and marginal

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Lung Function Variability in Children and Adolescents With and Without Asthma (LUV Study): Protocol for a Prospective, Nonrandomized, Clinical Trial

Cited by 5 publications

References 23 publications

Application of Metabolomics in Pediatric Asthma: Prediction, Diagnosis and Personalized Treatment

Application of Metabolomics in Pediatric Asthma: Prediction, Diagnosis and Personalized Treatment

Exercise Limitation in Children and Adolescents with Mild-to-Moderate Asthma

Oscillometry to Assess Respiratory Function in Adult Cystic Fibrosis

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