Lung imaging

Ley, Sebastian

doi:10.1183/16000617.00011214

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…The objective of this work was to investigate the correlation of radiomic features extracted from the lungs on CT images with two common pulmonary function tests (PFTs): (1) forced expiratory volume in one second ( FEV 1 ) measurements and (2) diffusing capacity of the lung for carbon monoxide ( DLCO ) measurements. CT is currently standard-of-care for lung imaging as it provides a high-resolution evaluation of lung parenchyma and surrounding pulmonary structures 12 . Spirometry is considered to be the gold-standard for accurate and repeatable measurements of lung function.…”

Section: Introductionmentioning

confidence: 99%

An Exploratory Radiomics Approach to Quantifying Pulmonary Function in CT Images

Lafata

Zhou

Liu

et al. 2019

Sci Rep

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Contemporary medical imaging is becoming increasingly more quantitative. The emerging field of radiomics is a leading example. By translating unstructured data (i.e., images) into structured data (i.e., imaging features), radiomics can potentially characterize clinically useful imaging phenotypes. In this paper, an exploratory radiomics approach is used to investigate the potential association between quantitative imaging features and pulmonary function in CT images. Thirty-nine radiomic features were extracted from the lungs of 64 patients as potential imaging biomarkers for pulmonary function. Collectively, these features capture the morphology of the lungs, as well as intensity variations, fine-texture, and coarse-texture of the pulmonary tissue. The extracted lung radiomics data was compared to conventional pulmonary function tests. In general, patients with larger lungs of homogeneous, low attenuating pulmonary tissue (as measured via radiomics) were found to be associated with poor spirometry performance and a lower diffusing capacity for carbon monoxide. Unsupervised dynamic data clustering revealed subsets of patients with similar lung radiomic patterns that were found to be associated with similar forced expiratory volume in one second (FEV 1 ) measurements. This implies that patients with similar radiomic feature vectors also presented with comparable spirometry performance, and were separable by varying degrees of pulmonary function as measured by imaging.

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Section: Introductionmentioning

confidence: 99%

An Exploratory Radiomics Approach to Quantifying Pulmonary Function in CT Images

Lafata

Zhou

Liu

et al. 2019

Sci Rep

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“…Imaging techniques such as (high-resolution) computed tomography (HRCT), X-ray, trans-thoracic ultrasound, PET and MRI are cornerstones in diagnosing a wide variety of pulmonary diseases [ 1 ]. Although these techniques provide important clinical insights, they are limited in resolution and unable to provide near-histological information.…”

Section: Introductionmentioning

confidence: 99%

Advances in bronchoscopic optical coherence tomography and confocal laser endomicroscopy in pulmonary diseases

Kramer¹,

Wijsman²,

Kalverda³

et al. 2022

Current Opinion in Pulmonary Medicine

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Purpose of reviewImaging techniques play a crucial role in the diagnostic work-up of pulmonary diseases but generally lack detailed information on a microscopic level. Optical coherence tomography (OCT) and confocal laser endomicroscopy (CLE) are imaging techniques which provide microscopic images in vivo during bronchoscopy. The purpose of this review is to describe recent advancements in the use of bronchoscopic OCT- and CLE-imaging in pulmonary medicine.Recent findingsIn recent years, OCT- and CLE-imaging have been evaluated in a wide variety of pulmonary diseases and demonstrated to be complementary to bronchoscopy for real-time, near-histological imaging. Several pulmonary compartments were visualized and characteristic patterns for disease were identified. In thoracic malignancy, OCT- and CLE-imaging can provide characterization of malignant tissue with the ability to identify the optimal sampling area. In interstitial lung disease (ILD), fibrotic patterns were detected by both (PS-) OCT and CLE, complementary to current HRCT-imaging. For obstructive lung diseases, (PS-) OCT enables to detect airway wall structures and remodelling, including changes in the airway smooth muscle and extracellular matrix.SummaryBronchoscopic OCT- and CLE-imaging allow high resolution imaging of airways, lung parenchyma, pleura, lung tumours and mediastinal lymph nodes. Although investigational at the moment, promising clinical applications are on the horizon.

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