Lung imaging in bronchopulmonary dysplasia: a systematic review

Vanhaverbeke, Kristien; Eyck, Annelies Van; Hoorenbeeck, Kim Van; Winter, Benedicte Y. De; Snoeckx, Annemie; Mulder, T.J.S. Van; Verhulst, Stijn

doi:10.1016/j.rmed.2020.106101

Cited by 16 publications

(17 citation statements)

References 65 publications

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“…57 Radiographical studies in the prediction of BPD Among imaging modalities, plain chest radiography and computed tomography scanning remain the most extensively studied in BPD. 58 Several different radiographic abnormalities have been associated with continued oxygen requirement at 36 weeks' PMA, including chronic pulmonary edema 59 and a "bubbly" cystic appearance. 59 60 A scoring system applied to radiographs on DOL 7 was found to correlate better with BPD diagnosis at DOL 28 than certain readily available clinical data.…”

Section: Physiological Measurements In the Diagnosis Of Bpdmentioning

confidence: 99%

“…Several qualitative, 65 semi-quantitative, 66 and quantitative 67 scoring systems have been proposed to predict the severity of long term respiratory outcome in BPD. 58 Most scoring systems involve rating of the degree of peri-bronchial wall thickening, areas of decreased attenuation, and the presence and severity of bullae and bronchiectasis. Computed tomography scoring systems correlate with a range of adverse physiological and clinical outcomes including duration of oxygen therapy, 66 desaturation events during sleep, 67 incidence of wheezing, 65 likelihood of hospital admission, 65 clinical severity scores, 66 68 and progressive decline in forced expiratory volume inone second (FEV 1 ) in patients who have had BPD.…”

Section: Physiological Measurements In the Diagnosis Of Bpdmentioning

confidence: 99%

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Diagnosis and management of bronchopulmonary dysplasia

Gilfillan

Bhandari

2021

BMJ

155

103

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Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in infants and is associated with increased mortality, respiratory morbidity, neurodevelopmental impairment, and increased healthcare costs. In parallel with advances made in the field of neonatal intensive care, the phenotype of BPD has evolved from a fibrocystic disease affecting late preterm infants to one of impaired parenchymal development and dysregulated vascular growth predominantly affecting infants born before 29 weeks’ gestational age. BPD has been shown to have significant lifelong consequences. Adults with BPD have been found to have abnormal lung function tests, reduced exercise tolerance, and may be at increased risk for developing chronic obstructive pulmonary disease. Evidence shows that BPD occurs secondary to genetic-environmental interactions in an immature lung. In this review, we evaluate the various clinical definitions, imaging modalities, and biomarker data that are helpful in making an early diagnosis of BPD. In addition, we evaluate recent evidence about the prevention and treatment of BPD. We discuss the invasive and non-invasive ventilation strategies and pharmacological agents used in the early, evolving, and established phases of BPD.

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Section: Physiological Measurements In the Diagnosis Of Bpdmentioning

confidence: 99%

Section: Physiological Measurements In the Diagnosis Of Bpdmentioning

confidence: 99%

Diagnosis and management of bronchopulmonary dysplasia

Gilfillan

Bhandari

2021

BMJ

155

103

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“…BPD is a prevalent respiratory complication of preterm birth. Radiography plays a critical role in the clinical evaluation of BPD ( 13 , 28 , 29 ). Our data demonstrated that typical imaging findings were associated with the severity of BPD, a higher rate of mortality and HOT at discharge.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Outcomes Until 2 Years of Age in Preterm Infants With Typical Chest Imaging Findings of Bronchopulmonary Dysplasia: A Propensity Score Analysis

2021

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Objective: The goal of the current study was to assess the associations of typical chest imaging findings of bronchopulmonary dysplasia (BPD) in preterm infants with clinical characteristics and outcomes until 2 years of age.Method: This retrospective cohort study enrolled 256 preterm infants with BPD who were admitted between 2014 and 2018. A propensity score analysis was used to adjust for confounding factors. The primary outcomes were the severity of BPD, home oxygen therapy (HOT) at discharge and mortality between 28 days after birth and 2 years of age. A multivariate logistic regression analysis was performed to identify related variables of mortality.Results: Seventy-eight patients with typical chest imaging findings were enrolled, of which 50 (64.1%) were first found by CXR, while 28 (35.9%) were first found by CT. In addition, 85.9% (67/78) were discovered before 36 weeks postmenstrual age (PMA) (gestational age [GA] < 32 weeks) or before 56 days after birth (GA > 32 weeks). After propensity score matching, the matched groups consisted of 58 pairs of patients. Those with typical imaging findings had a remarkably higher mortality rate (29.3 vs. 12.1%, p = 0.022, OR 3.021), higher proportion of severe BPD (32.8 vs. 12.1%, p = 0.003, OR 4.669) and higher rate of HOT at discharge (74.1 vs. 46.6%, p = 0.002, OR 3.291) than those without typical imaging findings. The multivariate logistic regression analysis showed that typical imaging findings ≤ 7 days and typical typical imaging findings >7 days were independent risk factors for mortality in preterm infants with BPD (OR 7.794, p = 0.004; OR 4.533, p = 0.001).Conclusions: More attention should be given to chest imaging findings of BPD, especially in the early stage (within 7 days). Early recognition of the development of BPD helps early individualized treatment of BPD.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT04163822.

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“…Among these, HRCT is considered as the most accurate and sensitive imaging modality for the detection of pulmonary structural abnormalities and may be a predictor for later outcomes. 16 However, the relations between HRCT and BPD clinical phenotypes and prognosis are still not clear. In order to identify those infants who are at greatest risks of poor outcomes, there is an urgent need to figure out the most sensitive feathers of HRCT to develop better strategies of monitoring and treatment.…”

Section: Introductionmentioning

confidence: 99%

Relationship between bronchopulmonary dysplasia phenotypes and clinical outcomes with HRCT score in preterm infants

Yao

2020

Preprint

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Background: To assess the relationship between high-resolution computed tomography (HRCT) abnormalities with the clinical phenotypes and outcomes in preterm bronchopulmonary dysplasia (BPD) infants. Methods: Totally, 81 preterm infants were enrolled between 2013 and 2020. Clinical phenotypes of BPD mainly include BPD severity, pulmonary hypertension (PH), and large airway lesion (LAL). The outcomes included death before hospital discharge, home oxygen treatment, or home pulmonary vasodilator therapy, were assessed. Total scores (TS) of high-resolution CT (HRCT) were summed in every lobe in 7 aspects: hyperaeration score (HS), composing decreased attenuation, mosaic attenuation, and bulla/bleb; parenchyma score (PS), composing linear lesions, consolidation, bronchial wall thickening, and bronchiectasis. Results: TS (r=0.49), HS (r=0.31), PS (r=0.30), decreased attenuation (r=0.21), mosaic attenuation (r=0.31), bulla/Bleb (r=0.27) and linear densities (r=0.55) displayed a correlation with BPD severity. TS (r=0.28), PS (r=0.35), linear densities (r=0.34) and consolidation (r=0.24) displayed a correlation with PH.

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Lung imaging in bronchopulmonary dysplasia: a systematic review

Cited by 16 publications

References 65 publications

Diagnosis and management of bronchopulmonary dysplasia

Diagnosis and management of bronchopulmonary dysplasia

Clinical Characteristics and Outcomes Until 2 Years of Age in Preterm Infants With Typical Chest Imaging Findings of Bronchopulmonary Dysplasia: A Propensity Score Analysis

Relationship between bronchopulmonary dysplasia phenotypes and clinical outcomes with HRCT score in preterm infants

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