Lung involvement in hypereosinophilic syndromes

Dulohery, Megan M.; Patel, R.; Schneider, Frank; Ryu, Jay H.

doi:10.1016/j.rmed.2010.09.011

Cited by 67 publications

(52 citation statements)

References 19 publications

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“…The distinction between lymphoid-variant hypereosinophilic syndrome (L-HES) [18] and ICEP was questionable for this case. Indeed lung involvement in HES consists mainly of patchy ground-glass opacities as presented by our patient [19]. However, we considered that case 4 had ICEP, considering the respiratory-only setting (single-organ disease) without any other organ involvement at diagnosis and during follow-up (clinical follow-up and cardiac ultrasound performed at 1 month, 6 months and then yearly) [18] and the low level of the abnormal TL clone in comparison with levels reported in L-HES [20] – this clone having been described at low levels in the general population [21].…”

Section: Discussionmentioning

confidence: 96%

Idiopathic eosinophilic pneumonia in children: the French experience

Giovannini‐Chami

Hadchouel

Nathan

et al. 2014

Orphanet J Rare Dis

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BackgroundIdiopathic eosinophilic pneumonia is extremely rare in children and adults. We present herein the first series describing the specificities of idiopathic chronic (ICEP) and acute (IAEP) eosinophilic pneumonia in children.MethodsWe retrospectively analyzed all cases of ICEP and IAEP in children that were retrieved from French Reference Centers for rare pediatric lung diseases.ResultsFive cases of pediatric ICEP were identified. Corticosteroid or immunosuppressive therapy dramatically improved the outcome in three cases. The remaining two cases had a persistent interstitial pattern with progressive development of cystic airspace lesions. Three cases of IAEP in adolescents were reported, with one requiring four days of extracorporeal membrane oxygenation.ConclusionICEP is a rare disease with a polymorphic clinical presentation in children. We identified patients with persistent interstitial patterns progressing to cystic airspace regions, for which the boundaries with idiopathic interstitial pneumonias are difficult to establish. We therefore propose a specific pediatric definition and classification algorithm. IAEP in children remains an inflammatory reaction of the lung to an acute toxic exposure, mainly tobacco, as in adults. International studies are required to comprehensively assess the various clinical forms of the disease as well as the appropriate therapeutic regimens.

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Section: Discussionmentioning

confidence: 96%

Idiopathic eosinophilic pneumonia in children: the French experience

Giovannini‐Chami

Hadchouel

Nathan

et al. 2014

Orphanet J Rare Dis

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“…Pulmonary manifestations may occur in up to 40% of patients with hypereosinophilic syndromes, though only a subset of these patients can truly be grouped in the category of pulmonary eosinophilia with distinct radiographic abnormalities, given that most individuals with HES and cough have clear chest X-rays (40,208). When they are present, infiltrates may occur in any region of the lungs.…”

Section: Hesmentioning

confidence: 99%

Eosinophilic Pneumonias

2012

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SUMMARY This review starts with discussions of several infectious causes of eosinophilic pneumonia, which are almost exclusively parasitic in nature. Pulmonary infections due specifically to Ascaris , hookworms, Strongyloides , Paragonimus , filariasis, and Toxocara are considered in detail. The discussion then moves to noninfectious causes of eosinophilic pulmonary infiltration, including allergic sensitization to Aspergillus , acute and chronic eosinophilic pneumonias, Churg-Strauss syndrome, hypereosinophilic syndromes, and pulmonary eosinophilia due to exposure to specific medications or toxins.

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“…In a previous study, of 49 patients with IHES, 63% had more than one kind of respiratory symptoms, and 43% showed abnormal findings by chest radiography or CT scan 8. However, despite the fact that lung is frequently involved in IHES, there have been only a few cases that have presented ARDS.…”

Section: Discussionmentioning

confidence: 87%

A Case of Idiopathic Hypereosinophilic Syndrome Presenting With Acute Respiratory Distress Syndrome

Lim

Lee

et al. 2014

Allergy Asthma Immunol Res

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Although idiopathic hypereosinophilic syndrome(IHES) commonly involves the lung, it is rarely associated with acute respiratory distress syndrome (ARDS). Here we describe a case of IHES presented in conjunction with ARDS. A 37-year-old male visited the emergency department at Samsung Medical Center, Seoul, Korea, with a chief complaint of dyspnea. Blood tests showed profound peripheral eosinophilia and thrombocytopenia. Patchy areas of consolidation with ground-glass opacity were noticed in both lower lung zones on chest radiography. Rapid progression of dyspnea and hypoxia despite supplement of oxygen necessitated the use of mechanical ventilation. Eosinophilic airway inflammation was subsequently confirmed by bronchoalveolar lavage, leading to a diagnosis of IHES. High-dose corticosteroids were administered, resulting in a dramatic clinical response.

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Lung involvement in hypereosinophilic syndromes

Abstract: One-quarter of HES patients manifested pulmonary involvement with variable radiologic findings. Asthma was more common in HES than previously reported. Most patients with pulmonary involvement in HES improve with currently available therapies.

Cited by 67 publications

References 19 publications

Idiopathic eosinophilic pneumonia in children: the French experience

Idiopathic eosinophilic pneumonia in children: the French experience

Eosinophilic Pneumonias

A Case of Idiopathic Hypereosinophilic Syndrome Presenting With Acute Respiratory Distress Syndrome

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