Lung involvement in juvenile idiopathic inflammatory myopathy: A systematic review

Abu-Rumeileh, Sarah; Marrani, Edoardo; Maniscalco, Valerio; Maccora, Ilaria; Pagnini, Ilaria; Mastrolia, Maria Vincenza; Rouster-Stevens, Kelly; Simonini, Gabriele

doi:10.1016/j.autrev.2023.103416

Cited by 6 publications

(4 citation statements)

References 77 publications

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“…Approximately 33% [ 16 ] of IIM patients can develop RPILD. ASS, accounting for 7.8% of IIMs, is associated with ILD in > 90% of cases [ 17 ], and ILD significantly contributes to increased prevalence and mortality in these patients [ 17 , 18 ], and ASS patients with ILD often experience more severe disease with rapid progression.…”

Section: Discussionmentioning

confidence: 99%

“…ASS, accounting for 7.8% of IIMs, is associated with ILD in > 90% of cases [ 17 ], and ILD significantly contributes to increased prevalence and mortality in these patients [ 17 , 18 ], and ASS patients with ILD often experience more severe disease with rapid progression. ILD associated with IIMs exhibit a high ICU admission rate of 26.7% and a mortality rate of 28.9% [ 16 ], emphasizing the importance of early diagnosis and aggressive treatment to prevent serious outcomes.…”

Section: Discussionmentioning

confidence: 99%

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Anti-synthetase syndrome in a child with pneumomediastinum: a case report and literature review

Lin,

Li,

Fan

et al. 2024

BMC Pulm Med

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Background Anti-synthetase syndrome (ASS) is a group of rare clinical subtypes within inflammatory myopathies, predominantly affecting adult females. Instances of critical illness associated with ASS in children are even rarer. Case presentation We report the case of a 7-year-old boy finally diagnosed with ASS, combined with pneumomediastinum. He presented with intermittent fever persisting for 12 days, paroxysmal cough for 11 days, chest pain, and shortness of breath for 4 days, prompting admission to our hospital. Pre-admission chest CT revealed diffuse pneumomediastinum, subcutaneous pneumatosis in the neck and bilateral chest wall, consolidation, atelectasis, and reticular nodular shadowing in both lungs, as well as pericardial effusion and bilateral pleural effusions. Laboratory tests revealed a positive result for serum MP immunoglobulin M (MP-IgM) and MP immunoglobulin G (MP-IgG). The patient was initially diagnosed with mycoplasma pneumoniae (MP) infection, and following 3 days of antibiotic treatment, the patient's tachypnea worsened. Positive results in muscle enzyme antibody tests included anti–PL-12 antibody IgG, anti–Jo-1 antibody IgG, and anti–RO-52 antibody IgG. Ultrasonography detected moderate effusions in the right shoulder, bilateral elbow, and knee joints. Corticosteroids pulse therapy was initiated on the 27th day following disease onset, and continued for 3 days, followed by sequential therapy for an additional 12 days. The child was discharged on the 43rd day, and subsequent follow-up revealed a significant improvement in consolidation and interstitial lesions in both lungs. Conclusions ASS in children may combine with rapidly progressive interstitial lung disease (RPILD) and pneumomediastinum. It is crucial to promptly identify concurrent immunologic abnormalities during the outbreak of MP, particularly when the disease exhibits rapid progression with ineffective conventional antibiotic therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Anti-synthetase syndrome in a child with pneumomediastinum: a case report and literature review

Lin,

Li,

Fan

et al. 2024

BMC Pulm Med

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“…В настоящее время существует точка зрения, что более правильно использовать термин «клинически амиопатический дерматомиозит», поскольку при углубленном обследовании у этой группы пациентов может выявляться поражение мышц и внутренних органов [81,82]. Возможно развитие кальциноза и язвенного поражения кожи [82], ИПЛ даже в отсутствие поражения мышц [83][84][85].…”

Section: ювенильные идиопатические воспалительные миопатииunclassified

“…Согласно данным S. Abu-Rumeileh и соавт. [85], в группе пациентов с ЮИВМ и ИПЛ антисинтетазный синдром был диагностирован у 7,8% детей.…”

Section: ювенильные идиопатические воспалительные миопатииunclassified

Problems of systemic connective tissue diseases of childhood in historical perspective

Kaleda,

Nikishina

2023

Naučno-praktičeskaâ revmatologiâ

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The relevance of study systemic connective tissue diseases with juvenile onset for modern medicine is determined by the trend towards their growth in the population, the difficulty of early diagnosis, the rapid development of disability and a poor life prognosis. The article presents the main achievements in the study of this group of diseases in children, with an emphasis on the most significant issues from a practical point of view related to diagnosis, classification, clinical features and modern approaches to treatment.

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Successful treatment with tofacitinib for anti-melanoma differentiation-associated gene 5 antibody-positive juvenile dermatomyositis: case reports and review of the literature

Yamazaki,

Shimizu,

Yakabe

et al. 2024

Immunological Medicine

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Lung involvement in juvenile idiopathic inflammatory myopathy: A systematic review

Cited by 6 publications

References 77 publications

Anti-synthetase syndrome in a child with pneumomediastinum: a case report and literature review

Anti-synthetase syndrome in a child with pneumomediastinum: a case report and literature review

Problems of systemic connective tissue diseases of childhood in historical perspective

Successful treatment with tofacitinib for anti-melanoma differentiation-associated gene 5 antibody-positive juvenile dermatomyositis: case reports and review of the literature

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