Lung-kidney interactions and their role in chronic kidney disease-associated pulmonary diseases

Bollenbecker, Seth; Czaya, Brian; Gutiérrez, Orlando M.; Krick, Stefanie

doi:10.1152/ajplung.00152.2021

Cited by 20 publications

(7 citation statements)

References 200 publications

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“…The mean age of CKD5-HD in Pakistan is 50 years, which is substantially lower than the average age in wealthy countries (16) . In contrast to our research, where the female-to-male ratio was 1:1, the average age in that investigation was about 45 years old.…”

Section: Discussionmentioning

confidence: 83%

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Iron Status Assessment in Chronic Kidney Disease Patients Preceding Dialysis: An Exploration of Anemia and Iron Deficiency

Naeem,

Zahid,

Safir

et al. 2023

PJMHS

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Objective: The most common kind of anemia, iron deficiency anemia (IDA), is very burdensome for those with chronic kidney disease (CKD). The incidence of IDA rises as renal function deteriorates. The incidence of IDA in CKD patients before the need for dialysis has not been well documented in Pakistan, even though the major cause of anemia in CKD individuals is a shortage of erythrocyte a hormone generated by the kidneys that stimulates red blood cell synthesis. This study's goal is to identify the incidence of IDA in people with kidney failure who are still not receiving dialysis. Methods: We included 188 pre-dialysis CKD patients, ages 18 to 75, of both sexes. Patients with apparent anemia-related reasons were eliminated. During OPD follow-up, it was then established what proportion of patients had IDA in their pre-dialysis CKD. Results: The patients who participated in the research had an average age of 46.03 years, with a standard deviation of 12.24 years. There were 188 patients in all, and 102 of them were men, making up around 54.26% of the sample. The study's 1.2 to 1 male-to-female ratio indicates that men were overrepresented. 73 people, or around 38.83% of the total patients in the research, were found to have iron deficiency anemia (IDA) among people with chronic kidney disease (CKD) who had not yet begun dialysis. Practical Implication: The causes of iron shortage in those with CKD are complicated by several variables, chief among them being decreased nutritional iron consumption and poor gastrointestinal absorption of iron, blood losses brought on by uremia-induced platelet disorder, and persistent inflammation related to CKD. As a result, owing to chronic inflammation causing a reactive rise in ferritin, individuals with CKD have much higher ferritin threshold levels for the absolute iron shortage. As a result, it is advised that patients with CKD before starting dialysis have blood ferritin levels below 100 µg/ml and over 200 µg/ml for those who are already receiving it Conclusions: According to the study, IDA occurs often in pre-dialysis CKD patients. By paying strict attention to the sources of IDA and replacing it, patients' outcomes may be improved. Keywords: anemia, dialysis, chronic kidney disease, erythrocyte, iron deficiency, hormone

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Section: Discussionmentioning

confidence: 83%

“…Another research indicated that 13.9 percent of 156 patients with chronic kidney disease had microcytic anemia (CKD stage not specified, existence of ESKD not ruled out), but did not offer a full description of IDA (16) . Anemia is a clinically important burden in CKD patients when the glomerular filtration rate (GFR) declines more often.…”

Section: Discussionmentioning

confidence: 99%

Iron Status Assessment in Chronic Kidney Disease Patients Preceding Dialysis: An Exploration of Anemia and Iron Deficiency

Naeem,

Zahid,

Safir

et al. 2023

PJMHS

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“…Although the mechanism of the complex interaction between the kidneys and lungs has not been clearly elucidated, systemic inflammation and oxidative stress have been shown to play important roles [ 19 , 20 ]. Alge et al [ 21 ], who highlighted the interactions between the kidney and lungs in critically ill patients, reported that acute kidney injury (AKI) increased the generation of inflammatory cytokines, such as interleukin-6 (IL-6), causing increased trafficking of lymphocytes and neutrophils to the lungs, which contributed to the acute response distance syndrome.…”

Section: Discussionmentioning

confidence: 99%

Association between serum creatinine levels and pulmonary function of Korean adults: the 2016-2019 Korea National Health and Nutrition Examination Survey

Yeun¹,

Kwak²,

Kim³

2023

Phys Act Nutr

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[Purpose] Research on the interaction between renal and lung functions has been conducted; however, studies on the general adult population are limited. This study aimed to investigate the association between serum creatinine levels and pulmonary function in Korean adults.[Methods] From the 2016–2019 Korean National Health and Nutrition Examination Survey, we recruited 11,380 participants who were 40 years or older for this study. Serum creatinine levels were divided into three groups: low, normal, and high. Pulmonary function was divided into three groups: normal, restrictive, and obstructive. The odds ratios for abnormal pulmonary function patterns were calculated using weighted multinomial logistic regression analysis.[Results] The odds ratios were 0.97 for low vs. normal (0.40–2.33) and 2.00 for high vs. normal (1.18–3.38) for the restrictive pattern, and 0.12 for low vs. normal (0.02–0.49) and 1.74 for high vs. normal (0.90–3.35) for the obstructive pattern after being adjusted for age, sex, smoking status, alcohol consumption, regular exercise, body mass index, diabetes mellitus, hypertension, cardiovascular disease, total energy, and total proteins.[Conclusion] High serum creatinine levels were associated with an increased odds ratio for restrictive and obstructive pulmonary function patterns. The odds ratio of the restrictive pattern was higher than that of the obstructive pattern. Screening for abnormal pulmonary function in individuals with high serum creatinine levels may be useful to ensure that there is no abnormal pulmonary function before the onset of potential pulmonary problems. Thus, this study highlights the relationship between renal and pulmonary function using serum creatine levels, which can be easily tested in the primary medical environment of the general population.

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“…Moreover, increasing the general intake of fruits and vegetables is an effective approach to reducing the risk of asthma [12]. Signi cantly, lung diseases are interconnected with various systemic diseases and conditions, including heart disease and chronic kidney disease (CKD) [13,14].…”

Section: Introductionmentioning

confidence: 99%

Fruit Intake and Respiratory Health: Results from Mendelian Randomization

Liao,

Zhou,

Chen

et al. 2023

Preprint

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Background Respiratory disease contributes to a substantial burden of disease and mortality. It continues to impact human health and the quality of life under the continuous advancements in prevention and treatment. As reported by previous research, dietary factors might be regarded as latent risk factors for lung disease, suggesting that a vegetarian diet can effectively reduce mortality. Methods In this study, genome-wide association studies (GWAS) were used to conduct Mendelian randomization (MR) analyses to explore the causal effect of fruit intake on respiratory disease burden including chronic obstructive pulmonary disease, bronchitis, emphysema, and asthma. MVMR was carried out to validate the results under the influence of the other kind of fruit intake. Results There was weak evidence for a possible causal relationship between fresh fruit intake and respiratory diseases, whereas a substantial and strong causality was found between dried fruit intake and the four outcomes (COPDIVW: OR (95% CI) = 0.32 (0.22, 0. 48), P value < 0.001; asthmaIVW: OR (95% CI) = 0.59 (0.44, 0.79), P value < 0.001; bronchitisIVW: OR (95% CI) = 0.50 (0.35, 0.73), P value < 0.001; emphysemaIVW: OR (95% CI) = 0.15 (0.05, 0.42), P value < 0.001), with stability confirmed by tests and MVMR. Conclusions Our study strengthens the evidence for a positive causal relationship between dried fruit intake and four common respiratory outcomes but fails to show an association between fresh fruit intake and the outcomes, and the reliability of the dietary intervention could be strengthened by further validation.

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Lung-kidney interactions and their role in chronic kidney disease-associated pulmonary diseases

Cited by 20 publications

References 200 publications

Iron Status Assessment in Chronic Kidney Disease Patients Preceding Dialysis: An Exploration of Anemia and Iron Deficiency

Iron Status Assessment in Chronic Kidney Disease Patients Preceding Dialysis: An Exploration of Anemia and Iron Deficiency

Association between serum creatinine levels and pulmonary function of Korean adults: the 2016-2019 Korea National Health and Nutrition Examination Survey

Fruit Intake and Respiratory Health: Results from Mendelian Randomization

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