Lung Lipid Composition and Surfactant Biology

Fisher, Aron B.

doi:10.1016/b978-0-12-404577-4.00022-9

Cited by 10 publications

(12 citation statements)

References 447 publications

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“…Similarly, SM and PS lipid classes were detected in lower amounts in the pulmonary surfactant, however, they also were described as being abundant in the whole lung tissue. In fact, our results of the lipid class distribution of the mouse lung homogenates are in agreement with these findings [ 3 , 53 ]. Our data clearly indicate that PC and cholesterol occupy major parts of the whole lung lipidome (Panel A in S2 Fig ).…”

Section: Discussionsupporting

confidence: 91%

“…Furthermore, pulmonary lipid distribution patterns of the whole lung tissue in comparison to the pulmonary surfactant lipid composition in different mammalian species were studied (see book chapters in ref) [ 3 , 53 ]. In this context, it is important to mention that the distribution pattern of the lipids in the lung tissue is heterogeneous between distinct species.…”

Section: Discussionmentioning

confidence: 99%

“…The lung is composed of more than 40 different pulmonary cell types, whose cellular membranes are enriched with lipids that perform a variety of functions including maintenance of the lung architecture [ 1 – 3 ]. In addition, alveolar epithelial type II cells of the pulmonary epithelium that are lining the alveolar surface synthesize and secrete surfactant into the alveolar space.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative lipidomic analysis of mouse lung during postnatal development by electrospray ionization tandem mass spectrometry

et al. 2018

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Lipids play very important roles in lung biology, mainly reducing the alveolar surface tension at the air-liquid interface thereby preventing end-expiratory collapse of the alveoli. In the present study we performed an extensive quantitative lipidomic analysis of mouse lung to provide the i) total lipid quantity, ii) distribution pattern of the major lipid classes, iii) composition of individual lipid species and iv) glycerophospholipid distribution pattern according to carbon chain length (total number of carbon atoms) and degree of unsaturation (total number of double bonds). We analysed and quantified 160 glycerophospholipid species, 24 sphingolipid species, 18 cholesteryl esters and cholesterol from lungs of a) newborn (P1), b) 15-day-old (P15) and c) 12-week-old adult mice (P84) to understand the changes occurring during postnatal pulmonary development. Our results revealed an increase in total lipid quantity, correlation of lipid class distribution in lung tissue and significant changes in the individual lipid species composition during postnatal lung development. Interestingly, we observed significant stage-specific alterations during this process. Especially, P1 lungs showed high content of monounsaturated lipid species; P15 lungs exhibited myristic and palmitic acid containing lipid species, whereas adult lungs were enriched with polyunsaturated lipid species. Taken together, our study provides an extensive quantitative lipidome of the postnatal mouse lung development, which may serve as a reference for a better understanding of lipid alterations and their functions in lung development and respiratory diseases associated with lipids.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Quantitative lipidomic analysis of mouse lung during postnatal development by electrospray ionization tandem mass spectrometry

et al. 2018

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“…As well, phosphatidylglycerol is the second most abundant phospholipid in the surfactant, but its contribution is much lower in the lung tissue. In contrast, phosphatidylethanolamine is abundant in the lung tissue but is present in low amounts in the surfactant 43 .…”

Section: Lipid Classes Compositionmentioning

confidence: 93%

“…Lung surfactant is composed of phospholipids (90%), specifically phosphatidylcholine, and proteins (10%) 45 . Phospholipids present in the surfactant are also present in the lung tissue, as part of lamellar bodies, although their proportions are different (in lavage fluid: 75-90% and in lamellar bodies: 60%) 43 . For example, phosphatidylcholine is the dominant phospholipid class in both surfactant and lung tissue, but its content is higher in the surfactant than in the lung tissue.…”

Section: Lipid Classes Compositionmentioning

confidence: 99%

Lipids of lung and lung fat emboli of the toothed whales (Odontoceti)

Arregui

Glandon

Quirós

et al. 2020

Sci Rep

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Lipids are biomolecules present in all living organisms that, apart from their physiological functions, can be involved in different pathologies. One of these pathologies is fat embolism, which has been described histologically in the lung of cetaceans in association with ship strikes and with gas and fat embolic syndrome. To assess pathological lung lipid composition, previous knowledge of healthy lung tissue lipid composition is essential; however, these studies are extremely scarce in cetaceans. In the present study we aimed first, to characterize the lipids ordinarily present in the lung tissue of seven cetacean species; and second, to better understand the etiopathogenesis of fat embolism by comparing the lipid composition of lungs positive for fat emboli, and those negative for emboli in Physeter macrocephalus and Ziphius cavirostris (two species in which fat emboli have been described). Results showed that lipid content and lipid classes did not differ among species or diving profiles. In contrast, fatty acid composition was significantly different between species, with C16:0 and C18:1ω9 explaining most of the differences. This baseline knowledge of healthy lung tissue lipid composition will be extremely useful in future studies assessing lung pathologies involving lipids. Concerning fat embolism, non-significant differences could be established between lipid content, lipid classes, and fatty acid composition. However, an unidentified peak was only found in the chromatogram for the two struck whales and merits further investigation.

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