Lung mechanics and respiratory morbidities in school-age children born moderate-to-late preterm

Dantas, Fabianne M N A; Magalhães, Paulo; Hora, Emilly Correia Nepomuceno; Andrade, Lívia Barboza de; Rizzo, José Ângelo; Peixoto, Décio Medeiros; Sarinho, Emanuel Sávio Cavalcanti

doi:10.1038/s41390-021-01538-y

Cited by 4 publications

(8 citation statements)

References 29 publications

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“…Once the responses from contacted study authors were collated, 18 articles satisfied the inclusion criteria. 14 , 15 , 16 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 15 studies reported expiratory airflow data from MLP participants, 14 , 15 , 16 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 eight of which compared MLP participants with term-born controls. 14 , 15 , 16 , 37 , 38 , 39 , 40 , 41 , 42 Three studies were not eligible for meta-analysis, with two unable to provide z-score data, 29 , 30 and one with indices of impulse oscillometry only.…”

Section: Resultsmentioning

confidence: 99%

“… 14 , 15 , 16 , 37 , 38 , 39 , 40 , 41 , 42 Three studies were not eligible for meta-analysis, with two unable to provide z-score data, 29 , 30 and one with indices of impulse oscillometry only. 28 Of the 15 studies eligible for meta-analysis, 15 reported a z-score for FEV 1 , FVC, and FEV 1 /FVC with 13 reporting FEF 25-75% . Though spirometry indices were not published as GLI z-score in five of the included studies, 14 , 33 , 35 , 38 , 39 these data were subsequently provided by four of the respective study authors.…”

Section: Resultsmentioning

confidence: 99%

“…Birth and perinatal characteristics of participants, sample size, pulmonary function tests performed and spirometry reference values used are presented in Table 1 . Included studies were published between 1993 and 2021 and varied in study design; observational cohort ( n = 8), 14 , 15 , 16 , 29 , 37 , 38 , 40 , 42 cross-sectional ( n = 8), 28 , 30 , 31 , 33 , 34 , 36 , 39 , 41 case control ( n = 1) 32 and RCT ( n = 1). 35 Three studies reported longitudinal spirometry measurements.…”

Section: Resultsmentioning

confidence: 99%

“… 35 Three studies reported longitudinal spirometry measurements. 14 , 15 , 37 The age of participants born MLP ranged from 5 to 25 years; 15 studies reported pulmonary function outcomes obtained from school-aged children and adolescents, 14 , 15 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 36 , 39 , 40 , 41 , 42 while three reported outcomes obtained from adults. 16 , 37 , 38 Most studies included participants that were born between 32 to <37 weeks gestation ( n = 14, 78%).…”

Section: Resultsmentioning

confidence: 99%

“… 14 , 15 , 16 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 Study Region MLP Birth Characteristics Sex (% Male) Assessment Gestational Age (wk) Birthweight (g) MLP Term MLP Age (years) No. of Participants Pulmonary Function Tests Conducted Spirometry Reference Values Mean SD Range Mean SD Mean SD Range MLP Term Aoyama et al, 2021 31 a USA 33.9 1.3 2189 592 72 NA 7.3 1.8 7 NA Spirometry GLI 2012 Arroyas et al, 2020 36 Spain 34.2 1.2 2014 526 51.4 NA 14.1 74 NA ...…”

Section: Methodsmentioning

confidence: 99%

See 4 more Smart Citations

Long-term expiratory airflow of infants born moderate-late preterm: A systematic review and meta-analysis

Berry

Nesci²,

Cheong³

et al. 2022

eClinicalMedicine

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Long-term expiratory airflow of infants born moderate-late preterm: A systematic review and meta-analysis

Berry

Nesci²,

Cheong³

et al. 2022

eClinicalMedicine

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Window of opportunity for respiratory oscillometry: A review of recent research

Kostorz‐Nosal

Jastrzębski

Błach

et al. 2023

Respiratory Physiology & Neurobiology

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Respiratory, cardio-metabolic and neurodevelopmental long-term outcomes of moderate to late preterm birth: not just a near term-population. A follow-up study

Alonso-Lopez,

Arroyas,

Beato

et al. 2024

Front. Med.

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IntroductionModerate-to-late preterm infants constitute the majority within the preterm infant population. Most research on preterm infants has focused on very preterm children, often treating moderate-to-late preterm infants as similar to full-term infants. Our objective was to compare clinical, respiratory, cardio-metabolic and neurodevelopmental outcomes in adolescents aged 12–15 years born moderate and late preterm with a control group of the same age born full-term.MethodsObservational cross-sectional study, comparing moderate-to-late preterm (32–36+6 weeks’ gestational age) with full-term adolescents (37–41+6 weeks’ gestational age; 75 each group). Perinatal and neonatal history were collected as well as data on respiratory evolution (ISAAC questionnaire for asthma symptoms for adolescents 13–14 years), anthropometric values, learning difficulties, behavioral test (screening questionnaire for high-performance autism spectrum disorder and evaluation test for attention deficit hyperactivity disorder), skin prick test, pulmonary function test, echocardiogram and blood pressure. A blood test with metabolic profile was conducted.ResultsModerate-to-late preterm adolescents had more current asthma [p = 0.008, OR3 (95% CI 1.26–7.14)] and longer duration of combined treatments to control asthma (inhaled corticosteroids and anti-leukotrienes; p = 0.048). Forced vital capacity <80% was detected more often in moderate-to-late preterm patients (p = 0.013). When assessing right ventricle, moderate-to-late preterm adolescents showed better tricuspid annular plane systolic excursion z-score (p = 0.003), shortening fraction (p < 0.001) and E/A ratio z-score (p = 0.002). Regarding left ventricular assessment, moderate-to-late preterm group had smaller ventricle diastolic diameter (p = 0.04) and lower posterior wall z-score values (p = 0.037). They also showed a better S’wave z-score (p = 0.027), E wave (p = 0.005), E/A ratio (p = 0.003) and a higher septal myocardial performance index z-score (p = 0.025). Moderate-to-late preterm adolescents presented lower weight z-score (p = 0.039), body mass index z-score (p = 0.013), Waterlow weight index (p = 0.006) and higher undernutrition index [p = 0.04; OR 1.4 (95% CI 1–1.9)]. Although there were no differences in neurodevelopmental survey or behavioral tests.ConclusionOur findings underscore the importance of extended follow-up for this predominant group of premature infants to identify potential respiratory, cardiac and anthropometric issues that may emerge in the future.

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Lung mechanics and respiratory morbidities in school-age children born moderate-to-late preterm

Cited by 4 publications

References 29 publications

Long-term expiratory airflow of infants born moderate-late preterm: A systematic review and meta-analysis

Long-term expiratory airflow of infants born moderate-late preterm: A systematic review and meta-analysis

Window of opportunity for respiratory oscillometry: A review of recent research

Respiratory, cardio-metabolic and neurodevelopmental long-term outcomes of moderate to late preterm birth: not just a near term-population. A follow-up study

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