Lung Metastases from Esophageal Granular Cell Tumor: An Undoubted Criterion for Malignancy

Machado, Isidro; Cruz, Julia; Arana, Estanislao; Peñalver-Cuesta, Juan Carlos; Arraras-Martínez, Miguel; Llombart‐Bosch, Antonio

doi:10.1016/j.jtho.2017.05.001

Cited by 7 publications

(3 citation statements)

References 12 publications

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“…Although eGCT is commonly considered a benign entity; there are rare cases that presented with lung and liver metastases [21][22][23]. There is a single report of eGCT secreting a serum tumor marker (carbohydrate antigen 19 − 9) [24].…”

Section: Discussionmentioning

confidence: 99%

Esophageal Granular Cell Tumor and Eosinophils: A Multicenter Experience

Reddi

Chandler

Cardona

et al. 2021

Preprint

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Background: Esophageal granular cell tumor (eGCT) is rare, and the recent literature suggests a link between eosinophilic esophagitis (EoE) and eGCT. The aim of our study was to determine if EoE or other disorders associated with eosinophilia are consistently associated with eGCT. Methods: We retrospectively searched pathology databases of three academic institutions from 1999 to 2018 for eGCTs. The archived slides and medical records were reviewed.Results: From 294,855 esophagogastroduodenoscopy procedures, 45 patients (17 males and 28 females) with eGCTs were identified. The patients were 30-73 years in age (median 50) had eGCT (0.2 – 2.0 cm, average 0.71). Thirteen had a history of gastroesophageal reflux disease, 5 had Barrett esophagus/goblet cell metaplasia and 1 had EoE. Thirty-four eGCTs had intralesional eosinophils (14 with peak >10 eosinophils/400x hpf); of these, 21 also had eosinophils in lamina propria (9 with peak >10 eosinophils/hpf). eGCT with atypical features (including nuclear enlargement and prominent nucleoli) were more likely to have increased eosinophils in non-epithelial compartments than those without atypia. Pleomorphism and spindled cells were seen in 3 eGCT cases (mean peak intralesional eosinophils: 43 per hpf); 2 of these had goblet cell metaplasia. We found no association between EoE and eGCT, p= 0.5966, (95% C.I. 0.0276, 6.5389, Fisher’s exact test). Instead, most patients had gastroesophageal reflux disease or Barrett esophagus.Conclusion: Eosinophilia, common in eGCT and adjacent stroma, likely drives atypical/reactive histologic features, but a pathogenic relationship between eosinophil rich inflammatory conditions and eGCT has not yet been established.

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Section: Discussionmentioning

confidence: 99%

Esophageal Granular Cell Tumor and Eosinophils: A Multicenter Experience

Reddi

Chandler

Cardona

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…It is also generally restricted to the submucosal layer of the esophagus. However, it was found that only 26% of patients have this typical aspect [7]. The esophageal GCTs can also be present as red or gray-white.…”

Section: Discussion and Literature Revisionmentioning

confidence: 99%

Case report sustained by literature review on the major approaches of the granular esophageal cell tumor

Martins

Santos

Tomaz

et al. 2021

MedNEXT J Med Health Sci

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Background: Granular Cell Tumors (GCT) are rare benign neoplasms with an estimated prevalence of 0,4% in retrospective series. About 8% of GCT are located in the gastrointestinal tract, having the esophagus as the main affected area. Malignancy was reported in 2-4% of cases and there are no well established treatment protocols. Case summary: It was present an oligo-symptomatic female patient with diagnosis of GCT presented on the endoscopy. Complementary investigation was based on endoscopic ultrasound (EUS). The treatment consisted of mucosectomy and endoscopic variceal ligation, evolving with a favorable outcome. Conclusion: Despite disagreement on protocols for treatment of GCT, mucosectomy appears to be an effective option.

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“…Although eGCT is commonly considered a benign entity; there are rare reports of cases that presented with lung and liver metastases. There is also a single report of eGCT secreting a tumor marker (carbohydrate antigen 19–9) [ 21 – 24 ]. Notably, we had no cases of metastatic eGCT in our patient cohort.…”

Section: Discussionmentioning

confidence: 99%

Esophageal granular cell tumor and eosinophils: a multicenter experience

et al. 2021

View full text Add to dashboard Cite

Background Esophageal granular cell tumor (eGCT) is rare, and the recent literature suggests a link between eosinophilic esophagitis (EoE) and eGCT. The aim of our study was to determine if EoE or other disorders associated with eosinophilia are consistently associated with eGCT. Methods We retrospectively searched pathology databases of three academic institutions from 1999 to 2018 for eGCTs. The archived slides and medical records were reviewed. Results From 294,855 esophagogastroduodenoscopy procedures, 45 patients (17 males and 28 females) with eGCTs were identified. The patients (30–73 years in age, median 50) had eGCT 0.2–2.0 cm in size (average 0.71). Thirteen had a history of gastroesophageal reflux disease, 5 had Barrett esophagus/goblet cell metaplasia and 1 had EoE. Thirty-four eGCTs had intralesional eosinophils (14 with peak > 10 eosinophils/400x hpf); of these, 21 also had eosinophils in lamina propria (9 with peak > 10 eosinophils/hpf). eGCT with atypical features (including nuclear enlargement and prominent nucleoli) were more likely to have increased eosinophils in non-epithelial compartments than those without atypia. Pleomorphism and spindled cells were seen in 3 eGCT cases (mean peak intralesional eosinophils: 43 per hpf); 2 of these had goblet cell metaplasia. We found no association between EoE and eGCT, p = 0.5966, (95% C.I. 0.0276, 6.5389, Fisher’s exact test). Instead, most patients had gastroesophageal reflux disease or Barrett esophagus. Conclusion Eosinophilia, common in eGCT and adjacent stroma, likely drives atypical/reactive histologic features, but a pathogenic relationship between eosinophil rich inflammatory conditions and eGCT has not yet been established.

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Lung Metastases from Esophageal Granular Cell Tumor: An Undoubted Criterion for Malignancy

Cited by 7 publications

References 12 publications

Esophageal Granular Cell Tumor and Eosinophils: A Multicenter Experience

Esophageal Granular Cell Tumor and Eosinophils: A Multicenter Experience

Case report sustained by literature review on the major approaches of the granular esophageal cell tumor

Esophageal granular cell tumor and eosinophils: a multicenter experience

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