Lung Metastasis of Ta Bladder Cancer: A Case Report and Literature Review

Abstract

A 66-year-old man with a history of multiple transurethral resections for recurrent bladder tumors, staged as Ta according to the International Union Against Cancer staging guidelines, presented with a complaint of dry cough. A round nodule with a diameter of 7.5 cm was detected in the lung by chest computed tomography, and a video-assisted thoracoscopic lobectomy was performed. Pulmonary metastasis of recurrent bladder cancer was diagnosed by immunohistochemistry staining for the urothelium-specific protein uroplakin Ia. Subsequently, 2 cycles of systemic chemotherapy were administered. Two and a half years after treatment, no recurrence of pulmonary lesions has been detected. A combination of complete resection of pulmonary lesions and systemic chemotherapy may result in a good prognosis for patients with non-muscle-invasive bladder cancer.

Transthoracic fine-needle aspiration cytology of non-invasive, low-grade urothelial carcinoma with lung metastasis: A case report with review of the literature

“…Prognosis was reported to be quite well in these patients, who received systemic chemotherapy after complete resection of the pulmonary lesion. [ 2 3 ] At the latest follow-up, our patient was without evidence of disease.…”

“… Staging inaccuracies, Intravascular spread of tumor cells during TUR, Basal membrane injury due to intravesicular therapy and, Sampling errors during TUR. [ 2 4 ] …”

“…While the 5-year recurrence rates for low-grade UC range between 31% and 78%, and the progression rate is between 5% and 25% in superficial UCs without muscular invasion, only 24 cases with extensive metastasis have been reported in the literature. [ 2 6 ] Thirteen of these tumors showed lung metastasis, with liver, bones, ovaries, orbit of the eye, brain and uterine corpus reported as other localizations for metastasis. [ 1 2 ]…”

“…[ 2 6 ] Thirteen of these tumors showed lung metastasis, with liver, bones, ovaries, orbit of the eye, brain and uterine corpus reported as other localizations for metastasis. [ 1 2 ]…”

“…[ 1 ] Metastasis is extremely rare for UCs without muscular invasion, although local relapses are common. [ 1 2 3 4 5 ] Here, we report a case of low-grade urothelial carcinoma of the bladder that had metastasized to the lung and review the literature concerning pulmonary metastases associated with low-grade superficial bladder tumors with no evidence of muscle-invasive disease, emphasizing the cytopathological features of this rare entity.…”