Lung metastasis-targeted donut-shaped nanostructures shuttled by the margination effect for the PolyDox generation-mediated penetrative delivery into deep tumors

Chiang, Min‐Ren; Su, Yu‐Lin; Chang, C C.; Chang, Chein-Wen; Hu, Shang‐Hsiu

doi:10.1039/c9mh01730e

Cited by 17 publications

(7 citation statements)

References 43 publications

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“…Within the treatment process, systemic toxicity ( Bourzac, 2014 ), drug resistance, and immune evasion ( Liu et al, 2020 ) seem to be inevitable. In this regard, nanoparticle formulation for lung cancer treatment is emerging ( Barenholz, 2012 ; Chiang et al, 2020 ), but the efficacy remains unknown ( Chen Y. et al, 2020 ). Drugs or radiotherapy ( Lang et al, 2019 ) can induce the production of excess ROS, leading to ferroptosis in lung cancer.…”

Section: Ferroptosis In Relevant Malignant Tumorsmentioning

confidence: 99%

A Promising Future of Ferroptosis in Tumor Therapy

Wang

Lin

et al. 2021

Front. Cell Dev. Biol.

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Currently, mechanisms and therapeutic approaches have been thoroughly studied in various prevalent malignant tumors, such as breast and lung cancer. However, there is inevitable tumor progression and drug resistance. Uncovering novel treatment strategies to inhibit tumor development is important. Ferroptosis, a form of cell death associated with iron and lipid peroxidation, has drawn extensive attention. In this paper, we reviewed the underlying mechanisms of ferroptosis (i.e., iron, glutathione, and lipid metabolism) and its role in various tumors (i.e., lung cancer, liver carcinoma, breast cancer, and pancreatic cancer). Moreover, we summarized ferroptosis-related anti-tumor drugs and emphasized the potential of combined treatment of anti-tumor drugs and radiotherapy in an effort to provide novel anti-tumor treatments.

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Section: Ferroptosis In Relevant Malignant Tumorsmentioning

confidence: 99%

A Promising Future of Ferroptosis in Tumor Therapy

Wang

Lin

et al. 2021

Front. Cell Dev. Biol.

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“…And then, Dox and poly‐ l ‐glutamic acid (PGA) were divided through cleavage of the pH‐sensitive hydrazone linker at the deep tumor site, resulting in activated Dox with high intracellular concentrations. In addition, NP‐induced extracellular leakiness (nanoEL) was induced by the disruption of the cadherin interactions as a result of the adhesion under the pressure of blood flow (Chiang, Su, Chang, Chang, & Hu, 2020). Zhongling et al reported a nano‐sized PEGylated superparamagnetic iron oxide (SPIO) NPs with anti‐EGFR monoclonal antibody (mAb) decoration for targeted delivery to EGFR‐overexpressed lung cancer.…”

Section: Deliver Drugs For Lung Cancer By Nanomaterialsmentioning

confidence: 99%

Nanomedicine in lung cancer: Current states of overcoming drug resistance and improving cancer immunotherapy

Wang

Hao

Liu

et al. 2020

WIREs Nanomed Nanobiotechnol

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Lung cancer is considered to cause the most cancer‐related deaths worldwide. Due to the deficiency in early‐stage diagnostics and local invasion or distant metastasis, the first line of treatment for most patients unsuitable for surgery is chemotherapy, targeted therapy or immunotherapy. Nanocarriers with the function of improving drug solubility, in vivo stability, drug distribution in the body, and sustained and targeted delivery, can effectively improve the effect of drug treatment and reduce toxic and side effects, and have been used in clinical treatment for lung cancer and many types of cancers. Here, we review nanoparticle (NP) formulation for lung cancer treatment including liposomes, polymers, and inorganic NPs via systemic and inhaled administration, and highlight the works of overcoming drug resistance and improving cancer immunotherapy. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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“…Recently, immune therapy held promise to suppress the metastatic cells via the cytotoxic T lymphocytes [ 6 , 7 , 8 ]. Despite the recent advance in immunotherapy, the invading clusters of metastases usually smaller than 100 mm 3 poorly performed vascularization and restricted physical contact of T lymphocytes, lowering immune responses [ 9 , 10 , 11 , 12 ]. Furthermore, the invasion of secondary tumors fills up the lymphatic vessels and reduces the space to recruit immune cells [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Programmed Catalytic Therapy-Mediated ROS Generation and T-Cell Infiltration in Lung Metastasis by a Dual Metal-Organic Framework (MOF) Nanoagent

et al. 2022

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Nano-catalytic agents actuating Fenton-like reaction in cancer cells cause intratumoral generation of reactive oxygen species (ROS), allowing the potential for immune therapy of tumor metastasis via the recognition of tumor-associated antigens. However, the self-defense mechanism of cancer cells, known as autophagy, and unsustained ROS generation often restricts efficiency, lowering the immune attack, especially in invading metastatic clusters. Here, a functional core-shell metal-organic framework nanocube (dual MOF) doubling as a catalytic agent and T cell infiltration inducer that programs ROS and inhibits autophagy is reported. The dual MOF integrated a Prussian blue (PB)-coated iron (Fe2+)-containing metal-organic framework (MOF, MIL88) as a programmed peroxide mimic in the cancer cells, facilitating the sustained ROS generation. With the assistance of Chloroquine (CQ), the inhibition of autophagy through lysosomal deacidification breaks off the self-defense mechanism and further improves the cytotoxicity. The purpose of this material design was to inhibit autophagy and ROS efficacy of the tumor, and eventually improve T cell recruitment for immune therapy of lung metastasis. The margination and internalization-mediated cancer cell uptake improve the accumulation of dual MOF of metastatic tumors in vivo. The effective catalytic dual MOF integrated dysfunctional autophagy at the metastasis elicits the ~3-fold recruitment of T lymphocytes. Such synergy of T cell recruitment and ROS generation transported by dual MOF during the metastases successfully suppresses more than 90% of tumor foci in the lung.

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Lung metastasis-targeted donut-shaped nanostructures shuttled by the margination effect for the PolyDox generation-mediated penetrative delivery into deep tumors

Abstract: A donut-shaped nanostructure effectively approaches the tumor and offers burst penetrative delivery of a large payload of drug to overcome tumor heterogeneity.

Cited by 17 publications

References 43 publications

A Promising Future of Ferroptosis in Tumor Therapy

A Promising Future of Ferroptosis in Tumor Therapy

Nanomedicine in lung cancer: Current states of overcoming drug resistance and improving cancer immunotherapy

Programmed Catalytic Therapy-Mediated ROS Generation and T-Cell Infiltration in Lung Metastasis by a Dual Metal-Organic Framework (MOF) Nanoagent

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