Lung Morphology: Fast MR Imaging Assessment with a Volumetric Interpolated Breath-Hold Technique: Initial Experience with Patients

Biederer, Jürgen; Both, Marcus; Graessner, Joachim; Liess, Carsten; Jakob, Peter M.; Reuter, M.; Heller, Martin

doi:10.1148/radiol.2261011974

Cited by 69 publications

(44 citation statements)

References 26 publications

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“…VIBE sequence has been proven to provide high spatial resolution, good visualization of lung anatomy, and low rates of artifact in healthy volunteers. These image qualities have been confirmed in recent studies using 3D-GRE sequences in a wide spectrum of malignant and benign pulmonary diseases (4,12). This technique involves two independent directionsperpendicular (phase-encoding) and parallel (partition-encoding) to the plane of excitation.…”

Section: Discussionmentioning

confidence: 57%

“…MRI of the lung is difficult and hampered by three factors: first (and very important) is signal loss due to physiological motion (respiration and cardiac pulsation); second is low proton density in lung results in a low signal-to-noise-ratio (SNR); and third is the unique combination of air and soft tissue resulting in significant susceptibility to artifact. Despite these difficulties, fast MRI techniques for evaluating lung pathology have been developed and addressed in a number of articles describing preliminary results (4)(5)(6). However, correct evaluation of PMF lesions by fast MRI techniques has not yet been well described.…”

mentioning

confidence: 99%

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Fast magnetic resonance imaging evaluating of pulmonary progressive massive fibrosis with vibe and HASTE sequences: comparison with computed tomography imaging

Hekimoğlu

Sancak²,

Tor³

et al. 2009

Diagn Interv Radiol

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Progressive massive fibrosis (PMF) of the lung is a type of late stage pneumoconiosis and pathologically consists of fibrotic lesions more than 1 cm in greatest diameter (1). The chest radiographic and computed tomography (CT) findings of PMF have been reported (2, 3). In our geographic region, PMF is mostly seen as a complication of coal workers' pneumoconiosis (CWP). Evaluation and follow-up of PMF lesions are generally performed by using CT scans in CWP patients. However, imaging has to provide detailed information about the anatomical extension of the PMF. Since CT imaging requires ionizing radiation and application of CT contrast agents is limited in patients with allergies to ionized contrast media or in patients with renal insufficiency, alternative imaging methods for diagnosis and follow-up are always of interest. If the fast magnetic resonance imaging (MRI) of PMF lesions of the lungs is proven to be diagnostically significant, this modality can be used instead of CT imaging. The rapid development of MRI techniques during the last years has resulted in excellent soft tissue imaging capabilities. MRI of the lung is difficult and hampered by three factors: first (and very important) is signal loss due to physiological motion (respiration and cardiac pulsation); second is low proton density in lung results in a low signal-to-noise-ratio (SNR); and third is the unique combination of air and soft tissue resulting in significant susceptibility to artifact. Despite these difficulties, fast MRI techniques for evaluating lung pathology have been developed and addressed in a number of articles describing preliminary results (4-6). However, correct evaluation of PMF lesions by fast MRI techniques has not yet been well described. Volumetric interpolated breath-hold examination (VIBE) and half-Fourier single-shot turbo spin echo (HASTE) MR sequences are very fast imaging techniques, and these techniques can also be used for fast pulmonary imaging.In the present study, we hypothesized that fast pulmonary MRI of the PMF lesions by using VIBE and HASTE fast MRI protocols would enable detection of lesions and might have a role in the management of PMF, especially in long-term follow-up. Thus, the purpose of our study was to determine the feasibility of fast MRI in the management of PMF in comparison with CT imaging. Materials and methods Study designTwenty-three patients were enrolled in this prospective study between January 2007 and July 2008. Three patients were unable to undergo MRI because of claustrophobia and had to be excluded from the study. Thus, data sets of 20 patients were analyzed for this study. All patients were male, with an age range of 52-82 years (mean, 72 years). The patients had worked as coal miners for 15-25 years (mean, 15 years) working underground. They had pulmonary mass lesions rang- CHEST IMAGING PURPOSEThe aim of this prospective study was to evaluate the diagnostic utility of volumetric interpolated breath-hold examination (VIBE) and half-Fourier-acquisition single-shot turbo spin-echo ...

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Section: Discussionmentioning

confidence: 57%

mentioning

confidence: 99%

Fast magnetic resonance imaging evaluating of pulmonary progressive massive fibrosis with vibe and HASTE sequences: comparison with computed tomography imaging

Hekimoğlu

Sancak²,

Tor³

et al. 2009

Diagn Interv Radiol

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“…High spatial resolution is essential for visualization of the airways, and can be achieved by T1-weighted 3D gradient echo sequences with a voxel size of %0.9 Â 0.88 Â 2.5 mm 3 . This technique showed a sensitivity of 79% and a specificity of 98% regarding visual depiction of bronchiectasis compared to CT (60). The intravenous application of contrast material markedly improves the diagnostic yield of T1-weighted sequences by a clearer depiction of vessels, hilar structures, and solid pathologies.…”

Section: Technical Aspectsmentioning

confidence: 95%

Imaging phenotypes of chronic obstructive pulmonary disease

Ley‐Zaporozhan¹,

Beek²

2010

Magnetic Resonance Imaging

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Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. COPD is defined by irreversible airflow obstruction. It is a heterogeneous disease affecting the airways and/or the parenchyma with different severity during the course of the disease. These different aspects of COPD can be addressed by imaging using a combination of morphological and functional techniques. Computed tomography (CT) is the technique of choice for morphological imaging of the lung parenchyma and airways. This morphological information is to be accomplished by functional information about ventilation and perfusion, mainly provided by magnetic resonance imaging (MRI). The comprehensive diagnostic possibilities of CT complemented by MRI will allow for a more sensitive detection, phenotype-driven characterization, and dedicated therapy monitoring of the disease.

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“…Xe]) magnetic resonance (MR) imaging is quickly becoming a newly accepted research standard for investigation of regional lung function and microstructure (1-6) with high-spatial-resolution ventilation images and maps of alveolar geometry (5,7). To date, a clear quantification of regional ventilation and regional structure-function relationships and how they relate to potential therapeutic interventions has been lacking, partly because of an inability to segment ventilation images into anatomically correct bronchopulmonary segments (8).…”

Section: Implication For Patient Carementioning

confidence: 99%

Regional Ventilation Changes in Severe Asthma after Bronchial Thermoplasty with³He MR Imaging and CT

Thomen¹,

Sheshadri²,

Quirk³

et al. 2015

Radiology

122

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).q RSNA, 2014 Purpose:To quantify regional lung ventilation in healthy volunteers and patients with severe asthma (both before and after thermoplasty) by using a combination of helium 3 ( 3 He) magnetic resonance (MR) imaging and computed tomography (CT), with the intention of developing more effective image-guided treatments for obstructive lung diseases. Materials andMethods:With approval of the local institutional review board, informed consent, and an Investigational New Drug Exemption, six healthy volunteers and 10 patients with severe asthma were imaged in compliance with HIPAA regulations by using both multidetector CT and 3He MR imaging. Individual bronchopulmonary segments were labeled voxel by voxel from the CT images and then registered to the Results:Ventilation measures for healthy volunteers yielded smaller segment-to-segment variation (mean SVP, 100% 6 18 [standard deviation]) than did the measures for patients with severe asthma (mean SVP, 97% 6 23). Patients with asthma also demonstrated larger segmental defect percentages (median, 13.5%; interquartile range, 8.9%-17.8%) than healthy volunteers (median, 6%; interquartile range, 5.6%-6.3%). These quantitative results confirm what is visually observed on the 3 He images. A Spearman correlation of r = 20.82 was found between the change in whole-lung defect percentage and the number of days between final treatment and second 3 He imaging. Conclusion:Regional quantification of lung ventilation is indeed feasible and may be a useful technique for image-guided treatment of obstructive lung diseases, such as bronchial thermoplasty for severe asthma. In these patients, ventilation defects decreased as a function of time after treatment.q RSNA, 2014

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Lung Morphology: Fast MR Imaging Assessment with a Volumetric Interpolated Breath-Hold Technique: Initial Experience with Patients

Abstract: Study results confirmed the feasibility of fast breath-hold 3D GRE MR imaging of the lung.

Cited by 69 publications

References 26 publications

Fast magnetic resonance imaging evaluating of pulmonary progressive massive fibrosis with vibe and HASTE sequences: comparison with computed tomography imaging

Fast magnetic resonance imaging evaluating of pulmonary progressive massive fibrosis with vibe and HASTE sequences: comparison with computed tomography imaging

Imaging phenotypes of chronic obstructive pulmonary disease

Regional Ventilation Changes in Severe Asthma after Bronchial Thermoplasty with³He MR Imaging and CT

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Lung Morphology: Fast MR Imaging Assessment with a Volumetric Interpolated Breath-Hold Technique: Initial Experience with Patients

Abstract: Study results confirmed the feasibility of fast breath-hold 3D GRE MR imaging of the lung.

Cited by 69 publications

References 26 publications

Fast magnetic resonance imaging evaluating of pulmonary progressive massive fibrosis with vibe and HASTE sequences: comparison with computed tomography imaging

Fast magnetic resonance imaging evaluating of pulmonary progressive massive fibrosis with vibe and HASTE sequences: comparison with computed tomography imaging

Imaging phenotypes of chronic obstructive pulmonary disease

Regional Ventilation Changes in Severe Asthma after Bronchial Thermoplasty with3He MR Imaging and CT

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Product

Resources

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Regional Ventilation Changes in Severe Asthma after Bronchial Thermoplasty with³He MR Imaging and CT