Lung morphometry using hyperpolarized <sup>129</sup>Xe multi‐<i>b</i> diffusion <scp>MRI</scp> with compressed sensing in healthy subjects and patients with <scp>COPD</scp>

Zhang, Huiting; Xie, Junshuai; Xiao, Sa; Xitao, Zhao; Zhang, Ming; Shi, Lei; Wang, Ke; Wu, Guangyao; Sun, Xiaofeng; Ye, Chaohui; Zhou, Xin

doi:10.1002/mp.12944

Cited by 31 publications

(48 citation statements)

References 47 publications

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“…Generally, hyperpolarized 129 Xe ventilation imaging could be utilized to quantify pulmonary ventilation defects in the lungs . By applying models of diffusion, changes in the pulmonary microstructure caused by lung diseases, such as COPD, can be quantified by multi‐ b diffusion‐weighted imaging (DWI) and diffusion kurtosis imaging . Additionally, hyperpolarized 129 Xe MR has unique advantages in exploring the gas exchange function of the lungs attributed to the increased chemical sensitivity to its surrounding environment and high solubility in tissue and blood.…”

Section: Introductionmentioning

confidence: 99%

Quantitative evaluation of lung injury caused by PM_2.5 using hyperpolarized gas magnetic resonance

Zhang

et al. 2019

Magnetic Resonance in Med

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Purpose:To demonstrate the feasibility of 129 Xe MR in evaluating the pulmonary physiological changes caused by PM 2.5 in animal models. Methods: Six rats were treated with PM 2.5 solution (16.2 mg/kg) by intratracheal instillation twice a week for 4 weeks, and another six rats treated with normal saline served as the control cohort. Pulmonary function tests, hyperpolarized 129 Xe multi-b diffusion-weighted imaging, and chemical shift saturation recovery MR spectroscopy were performed on all rats, and the pulmonary structure and functional parameters were obtained from hyperpolarized 129 Xe MR data. Additionally, histological analysis was performed on all rats to evaluate alveolar septal thickness. Statistical analysis of all the obtained parameters was performed using unpaired 2-tailed t tests. Results: Compared with the control group, the measured exchange time constant increased from 11.74 ± 2.39 to 14.00 ± 2.84 ms (P < .05), and the septal wall thickness increased from 6.17 ± 0.48 to 6.74 ± 0.52 μm (P < .05) in the PM 2.5 cohort by 129 Xe MR spectroscopy, which correlated well with that obtained using quantitative histology (increased from 5.52 ± 0.32 to 6.20 ± 0.36 μm). Additionally, the mean TP/GAS ratio increased from 0.828 ± 0.115 to 1.019 ± 0.140 in the PM 2.5 cohort (P = .021). Conclusions: Hyperpolarized 129 Xe MR could quantify the changes in gas exchange physiology caused by PM 2.5 , indicating that the technique has the potential to be a useful tool for evaluation of pulmonary injury caused by air pollution in the future. K E Y W O R D Sair pollution, gas exchange, hyperpolarized 129 Xe, lung injury, PM 2.5 570 | ZHANG et Al.

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Section: Introductionmentioning

confidence: 99%

Quantitative evaluation of lung injury caused by PM_2.5 using hyperpolarized gas magnetic resonance

Zhang

et al. 2019

Magnetic Resonance in Med

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“…Until now, however, and in a few specific cases, thoracic imaging is not routinely used in the clinical work-up or follow-up of patients with chronic lung disease. The application of MRI morphometry methods and measurements in patients with COPD, 53,66,67,82,[93][94][95]101,152 cystic fibrosis, 99 BPD, 104 and AATD 54,97 has well demonstrated its clinical potential and opens the door for more personalized and perhaps augmented therapy for these patients. For example, in AATD patients, including those undergoing augmentation therapy or cell-based therapy, there is a potential clinical benefit because response to therapy can be measured using MRI-derived L m .…”

Section: Role In the Futurementioning

confidence: 99%

Advanced pulmonary MRI to quantify alveolar and acinar duct abnormalities: Current status and future clinical applications

Westcott

McCormack

Párraga

et al. 2019

Magnetic Resonance Imaging

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There are serious clinical gaps in our understanding of chronic lung disease that require novel, sensitive, and noninvasive in vivo measurements of the lung parenchyma to measure disease pathogenesis and progressive changes over time as well as response to treatment. Until recently, our knowledge and appreciation of the tissue changes that accompany lung disease has depended on ex vivo biopsy and concomitant histological and stereological measurements. These measurements have revealed the underlying pathologies that drive lung disease and have provided important observations about airway occlusion, obliteration of the terminal bronchioles and airspace enlargement, or fibrosis and their roles in disease initiation and progression. ex vivo tissue stereology and histology are the established gold standards and, more recently, micro‐computed tomography (CT) measurements of ex vivo tissue samples has also been employed to reveal new mechanistic findings about the progression of obstructive lung disease in patients. While these approaches have provided important understandings using ex vivo analysis of excised samples, recently developed hyperpolarized noble gas MRI methods provide an opportunity to noninvasively measure acinar duct and terminal airway dimensions and geometry in vivo, and, without radiation burden. Therefore, in this review we summarize emerging pulmonary MRI morphometry methods that provide noninvasive in vivo measurements of the lung in patients with bronchopulmonary dysplasia and chronic obstructive pulmonary disease, among others. We discuss new findings, future research directions, as well as clinical opportunities to address current gaps in patient care and for testing of new therapies. Level of Evidence: 5 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2019;50:28–40.

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“…The X-Centric approach could eliminate 90% of the signal loss due to incidental diffusionweighting in the major airways. Parallel imaging approaches [64] or compressed sensing approaches [65,66] can also speed up data acquisition even more and are a straight-forward extension of the X-Centric approach described here.…”

Section: Future Role Of X-centricmentioning

confidence: 99%

High Resolution³He Pulmonary MRI

Fox¹,

Ouriadov²

2019

Magnetic Resonance Imaging

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Hyperpolarized gas MRI of the mouse lung is of great interest due to the urgent need for novel biomarkers for the assessment of respiratory-disease progression and development of new therapies. Small animal 3 He lung MRI requires high-spatialresolution imaging (<500 μm) to obtain acceptable images for visualization of all branches of lung microstructure from the mouse trachea to lung parenchyma. The use of conventional fast-gradient-recalled echo (FGRE) pulse sequences for highspatial-resolution mouse lung imaging is challenging due to the signal loss caused by significant diffusion-weighting by the imaging gradients, particularly in larger airways where 3 He diffusion is maximized. In this chapter, a modified FGRE approach called X-Centric is described for acquiring 3 He mouse lung MRI. X-Centric is a center-out technique, allowing high-spatial-resolution, and high signal-to-noise ratio density-weighted imaging, as it is a short-TE method minimizing diffusion decay. Here, we also take advantage of a high-performance insertable-gradient-set interfaced with a clinical MRI system and a custom-built constant-volume ventilator to get the maximum benefits of X-Centric. High-spatial-resolution 3 He X-Centric imaging was performed in a phantom and mouse lungs, yielding a nominal resolution of 39 μm and 78 μm respectively. We also demonstrate the feasibility of 129 Xe/ 19 F X-Centric MRI in a phantom and in rat lungs.

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Lung morphometry using hyperpolarized ¹²⁹Xe multi‐b diffusion MRI with compressed sensing in healthy subjects and patients with COPD

Abstract: Our study has shown that HP Xe multi-b diffusion MRI with CS could be beneficial in lung microstructural assessments by acquiring less data while maintaining the consistent results with the FS acquisitions.

Cited by 31 publications

References 47 publications

Quantitative evaluation of lung injury caused by PM_2.5 using hyperpolarized gas magnetic resonance

Quantitative evaluation of lung injury caused by PM_2.5 using hyperpolarized gas magnetic resonance

Advanced pulmonary MRI to quantify alveolar and acinar duct abnormalities: Current status and future clinical applications

High Resolution³He Pulmonary MRI

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Lung morphometry using hyperpolarized 129Xe multi‐b diffusion MRI with compressed sensing in healthy subjects and patients with COPD

Abstract: Our study has shown that HP Xe multi-b diffusion MRI with CS could be beneficial in lung microstructural assessments by acquiring less data while maintaining the consistent results with the FS acquisitions.

Cited by 31 publications

References 47 publications

Quantitative evaluation of lung injury caused by PM2.5 using hyperpolarized gas magnetic resonance

Quantitative evaluation of lung injury caused by PM2.5 using hyperpolarized gas magnetic resonance

Advanced pulmonary MRI to quantify alveolar and acinar duct abnormalities: Current status and future clinical applications

High Resolution3He Pulmonary MRI

Contact Info

Product

Resources

About

Lung morphometry using hyperpolarized ¹²⁹Xe multi‐b diffusion MRI with compressed sensing in healthy subjects and patients with COPD

Quantitative evaluation of lung injury caused by PM_2.5 using hyperpolarized gas magnetic resonance

Quantitative evaluation of lung injury caused by PM_2.5 using hyperpolarized gas magnetic resonance

High Resolution³He Pulmonary MRI