“…Accurate and robust lesion detection is a key component of an automated medical diagnosis system [1], [2], [3], [4], [5], [6], [7], [8]. Notable achievements in deep learning have benefited several research trials in medical image analysis, [9], [10], [11], [12], [13], [14], [15], [16] and the most recent major lesion detection algorithms are based on convolutional neural networks. In particular, semantic segmentation methods such as U-Net [17] allow for precise lesion detection with respect to intensity and shape variations.…”