Lung Protective Ventilation (Lpv) for Acute Lung Injury (Ali) Does Not Increase Sedation Use

Veberes, Liane; Day, Darcy; Spencer, Tina L.

doi:10.1097/00003246-200212001-00326

Cited by 3 publications

(1 citation statement)

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“…Paralysis was not part of the ARDS Network protocol; most subjects in our study were heavily sedated but not paralyzed (20,21). Respiratory therapists were instructed to not record a value but to indicate "assisting" if patients made respiratory efforts during attempted measurement of total PEEP.…”

Section: Discussionmentioning

confidence: 99%

Intrinsic positive end-expiratory pressure in Acute Respiratory Distress Syndrome (ARDS) Network subjects

Hough

Kallet

Rubenfeld

et al. 2005

Critical Care Medicine

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In a subgroup of ARDS Network subjects, intrinsic PEEP was statistically significantly higher in subjects randomized to the 6 mL/kg protocol than those in the 12 mL/kg study group. The amount of intrinsic PEEP was very low in both study groups, and difference of median intrinsic PEEP between the groups was <1 cm H2O. It is unlikely that the difference in intrinsic PEEP between the study groups was clinically important in the ARDS Network study of low tidal volume ventilation.

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Section: Discussionmentioning

confidence: 99%

Intrinsic positive end-expiratory pressure in Acute Respiratory Distress Syndrome (ARDS) Network subjects

Hough

Kallet

Rubenfeld

et al. 2005

Critical Care Medicine

View full text Add to dashboard Cite

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Low tidal volume ventilation does not increase sedation use in patients with acute lung injury*

Kahn

Andersson

Karir

et al. 2005

Critical Care Medicine

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Clinical Issues and Research in Respiratory Failure from Severe Acute Respiratory Syndrome

Levy

Baylor

Bernard

et al. 2005

Am J Respir Crit Care Med

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The National Heart, Lung, and Blood Institute, along with the Centers for Disease Control and Prevention and the National Institute of Allergy and Infectious Diseases, convened a panel to develop recommendations for treatment, prevention, and research for respiratory failure from severe acute respiratory syndrome (SARS) and other newly emerging infections. The clinical and pathological features of acute lung injury (ALI) from SARS appear indistinguishable from ALI from other causes. The mainstay of treatments for ALI remains supportive. Patients with ALI from SARS who require mechanical ventilation should receive a lung protective, low tidal volume strategy. Adjuvant treatments recommended include prevention of venous thromboembolism, stress ulcer prophylaxis, and semirecumbent positioning during ventilation. Based on previous experience in Canada, infection control resources and protocols were recommended. Leadership structure, communication, training, and morale are an essential aspect of SARS management. A multicenter, placebo-controlled trial of corticosteroids for late SARS is justified because of widespread clinical use and uncertainties about relative risks and benefits. Studies of combined pathophysiologic endpoints were recommended, with mortality as a secondary endpoint. The group recommended preparation for studies, including protocols, ethical considerations, Web-based registries, and data entry systems.

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Lung Protective Ventilation (Lpv) for Acute Lung Injury (Ali) Does Not Increase Sedation Use

Cited by 3 publications

References 0 publications

Intrinsic positive end-expiratory pressure in Acute Respiratory Distress Syndrome (ARDS) Network subjects

Intrinsic positive end-expiratory pressure in Acute Respiratory Distress Syndrome (ARDS) Network subjects

Low tidal volume ventilation does not increase sedation use in patients with acute lung injury*

Clinical Issues and Research in Respiratory Failure from Severe Acute Respiratory Syndrome

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