Lung reflexes in rabbits during pulmonary stretch receptor block by sulphur dioxide

Davies, Andrew; Dixon, M; Callanan, Deborah L.; Huszczuk, A; Widdicombe, J. G.; Wise, J. C. M.

doi:10.1016/0034-5687(78)90050-6

Cited by 93 publications

(36 citation statements)

References 29 publications

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“…The action potentials were picked up by two platinum electrodes and amplified electronically. Initially, phrenic activity was integrated using a 'non-leaky' integrator (Davies and Wise, 1978). The phrenic integral was used to define tj and t^ on the basis that t, is the interval between the initial increase and levelling off of the phrenic integral, t^ being the interval between the end of one inspiratory duration and the beginning of the next.…”

Section: Methodsmentioning

confidence: 99%

“…Pressure was maintained for eight breaths and released, either in expiration (positive pressure) or inspiration (negative pressure). Pulmonary stretch receptor activity was blocked by causing the anaesthetised rabbit to breathe 200 parts per million SO, in air for 10 min (Davies et al, 1978). Abolition of the Hering-Breuer inflation reflex to a lung inflation of 1-5 k.Pa (15 cm.…”

Section: Methodsmentioning

confidence: 99%

“…To see if this is so, we have used a highly specific method of blocking stretch receptors (Davies et aL, 1978) to investigate their role in control of duration of inspiration and expiration in anaesthetised rabbits, in which breathing was stimulated by carbon dioxide or took place against positive or negative pressure.…”

Section: Introductionmentioning

confidence: 99%

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A Role of Pulmonary Rapidly Adapting Receptors in Control of Breathing

Davies

Roumy

1986

Aust J Exp Biol Med

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Summary.We analysed the breathing pattern of anaesthetised rabbits during unloaded breathing when breathing was accelerated by inspired COj and when they breathed against positive or negative pressures before and during block of pulmonary stretch receptors by SO2, and after bilateral vagotomy. Before block moderate steps of inflation or deflation (0-5 kPa) produced relatively larger changes in duration of expiration than in duration of inspiration, indicating the relative sensitivities of the two phases. With stretch receptors, blocked inflation or deflation shortened expiration, demonstrating the influence of rapidly adapting receptors on that phase of breathing. If pulmonary stretch receptors were the major determinants of the duration of inspiration, we would have expected inspiratory duration in the stretch receptor blocked and vagotomised states to be almost identical. They were not, inspiratory duration being less in the blocked than in the vagotomised state. Possibly vagal afferent activity other than that of stretch receptors shortens inspiratory duration. However, we have found that rapidly adapting receptor activity (and any unmyelinated fibre activity provoked by rapid inflation or deflation of the lungs) never directly shortened inspiration. We therefore propose a mechanism whereby rapidly adapting receptors may indirectly affect duration of Inspiration.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A Role of Pulmonary Rapidly Adapting Receptors in Control of Breathing

Davies

Roumy

1986

Aust J Exp Biol Med

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“…Five minutes after drinking hypertonic saline, plasma AVP had fallen significantly from 1-8 + 0-3 to 0-9 + 0-2 pmol/l (P < 0-05 Post-inspiratory diaphragm activity in rabbits after block of slowly adapting stretch receptors in all thoracic airways or in bronchi alone BY E. AGOSTONI and G. CITTERIO. 1st Institute of Human Physiology, University of Milan, Milan, Italy In eleven rabbits anaesthetized with Nembutal and Urethane a selective block of slowly adapting stretch receptors (SAR) was induced by exposing to SO2 (Davies, Dixon, Callanan, Huszczuk, Widdicombe & Wise, 1978) all thoracic airways or the carina and bronchi alone. The moving time average of the sternal diaphragm e.m.g.…”

Section: By M Chowdhury and Marianne Fillenz University Laboratory mentioning

confidence: 99%

Proceedings of the Physiological Society and the Societa Italiana Di Fisiologia, 11‐13 July 1985, Oxford Meeting: Poster Communications

1985

The Journal of Physiology

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“…Vagal afferents are potentially implicated. Chest compression and lung deflation could potentially reduce the input from stretch receptors with resultant tachypnoea, and simultaneously increase the input of rapidly adapting vagal receptors, which increase respiratory drive and ventilation, thus contributing to dyspnoea [24,25].…”

Section: Rapid Breathingmentioning

confidence: 99%

Understanding dyspnoea by its language: Fig. 1—

Scano¹

2005

Eur Respir J

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Dyspnoea is a general term used to characterise a range of qualitatively distinct descriptors that vary in intensity. Based on the hypothesis that various qualities of respiratory discomfort result from different pathophysiological abnormalities, language could help to define one or more of the abnormalities responsible for breathing discomfort. The use of descriptors of dyspnoea may contribute to the understanding of the mechanisms of dyspnoea, and assist in identifying or predicting a specific diagnosis. Symptoms that can be reliably discriminated imply different pathophysiological mechanisms, whereas symptoms that cannot be reliably discriminated imply similar pathophysiological mechanisms. Since dyspnoea is a fundamental part of patient's clinical history, physicians should become more fluent in the language of dyspnoea.

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Lung reflexes in rabbits during pulmonary stretch receptor block by sulphur dioxide

Cited by 93 publications

References 29 publications

A Role of Pulmonary Rapidly Adapting Receptors in Control of Breathing

A Role of Pulmonary Rapidly Adapting Receptors in Control of Breathing

Proceedings of the Physiological Society and the Societa Italiana Di Fisiologia, 11‐13 July 1985, Oxford Meeting: Poster Communications

Understanding dyspnoea by its language: Fig. 1—

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