Lung Regeneration

Nichols, Joan E.; Cortiella, Joaquin

doi:10.1016/b978-0-12-398523-1.00048-3

Cited by 1 publication

(1 citation statement)

References 102 publications

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“…For example, bioresobable polylactic acid was processed into nano-scaffolds for lung tissue engineering that support lung cells proliferated on the 3D structure [113]. With better controlled nano/micro structure, chemical/physical properties and microenvironment in combination with stem cells or progenitor cells, novel products in regenerative medicine can be synthesized [114]. For example, Cortiella et al [115] seeded somatic lung progenitor cells on a polyglycolic acid/Pluronic F-127 hydrogel scaffold in vitro and implanted the complex in vivo.…”

Section: Lung Remodeling and Regenerationmentioning

confidence: 99%

Nanomaterials for Management of Lung Disorders and Drug Delivery

Menon¹,

Wadajkar²,

Xie³

et al. 2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

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There has been an increasing interest in pulmonary drug delivery and lung tissue regeneration to treat lung disorders in the past two decades. This route of administration is advantageous for both systemic as well as local drug delivery due to the large surface area available in the lung for drug absorption, higher permeability to solutes, and the noninvasive nature of treatment. Inhalational drug delivery is also highly beneficial for the diagnosis and treatment of lung diseases such as pulmonary arterial hypertension, cystic fibrosis, asthma, and lung cancer. Statistics show that lung cancer alone is responsible for nearly 1.3 million deaths worldwide every year, necessitating the need for alternative treatment methods, which can cure the disease while reducing discomfort to the patient. This chapter attempts to summarize the different types of nanoparticles (NPs) currently available for pulmonary drug delivery, the various targeting mechanisms for drug delivery and uptake, the applications of these NPs, and the current challenges faced in inhalational drug delivery. Further, the lung half-life of the NPs and their clearance rate from the lung following administration will also be discussed.

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Section: Lung Remodeling and Regenerationmentioning

confidence: 99%