Lung resided monocytic myeloid-derived suppressor cells contribute to premetastatic niche formation by enhancing MMP-9 expression

Zhang, Juechao; Han, Xiaoqing; Shi, Huifang; Gao, Yanyan; Qiao, Xuan; Li, Huihan; Wei, Min; Zeng, Xianlu

doi:10.1016/j.mcp.2019.101498

Cited by 21 publications

(14 citation statements)

References 41 publications

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“…These newly produced ECM molecules activate integrin-mediated signaling pathways in the incoming cancer cells, leading to cancer cell survival and proliferation [ 106 ]. For their part, activated macrophages release MMP-9 which further remodels the structure of local ECM to favor the homing of disseminated cancer cells at distant sites [ 107 , 108 , 109 ]. Later, exosomes released by normal cells residing in metastasis target organ(s) upregulate MMP-9 expression in the incoming cancer cells [ 110 , 111 , 112 , 113 ].…”

Section: Mmp-9 Favors Tumor Cell Adaptation To the Microenvironmenmentioning

confidence: 99%

The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process

Barillari

2020

IJMS

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In industrialized countries, cancer is the second leading cause of death after cardiovascular disease. Most cancer patients die because of metastases, which consist of the self-transplantation of malignant cells in anatomical sites other than the one from where the tumor arose. Disseminated cancer cells retain the phenotypic features of the primary tumor, and display very poor differentiation indices and functional regulation. Upon arrival at the target organ, they replace preexisting, normal cells, thereby permanently compromising the patient’s health; the metastasis can, in turn, metastasize. The spread of cancer cells implies the degradation of the extracellular matrix by a variety of enzymes, among which the matrix metalloproteinase (MMP)-9 is particularly effective. This article reviews the available published literature concerning the important role that MMP-9 has in the metastatic process. Additionally, information is provided on therapeutic approaches aimed at counteracting, or even preventing, the development of metastasis via the use of MMP-9 antagonists.

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Section: Mmp-9 Favors Tumor Cell Adaptation To the Microenvironmenmentioning

confidence: 99%

The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process

Barillari

2020

IJMS

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“…To successfully sow the surviving CTCs into the secondary soil, the primary soil will secrete tumor-derived factors and extracellular vesicles (EVs) prior to the dissemination of tumor cells to reshape the potential metastatic sites into favorable environment 132 , 133 , which is termed as premetastatic niche (PMN). In detail, the PMN will undergo a series of alternations including increased adhesion molecules on the endothelial cells, enhanced vascular permeability, recruitment of myeloid cells, overexpressed inﬂammatory molecules, up-regulated MMP-9 in the ECM and hypoxia 133 , 134 , 135 , 136 , 137 , 138 . These factors synergize to construct immunosuppressive and inﬂammatory microenvironment, facilitating extravasation, invasion, and colonization of CTCs.…”

Section: Modulating Premetastatic Niche (Premetastatic Soil) Via Nano-dds: Inhibiting Metastatic Colonizationmentioning

confidence: 99%

Emerging nanomedicine-based therapeutics for hematogenous metastatic cascade inhibition: Interfering with the crosstalk between “seed and soil”

Long

et al. 2021

Acta Pharmaceutica Sinica B

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Despite considerable progresses in cancer treatment, tumor metastasis is still a thorny issue, which leads to majority of cancer-related deaths. In hematogenous metastasis, the concept of “seed and soil” suggests that the crosstalk between cancer cells (seeds) and premetastatic niche (soil) facilitates tumor metastasis. Considerable efforts have been dedicated to inhibit the tumor metastatic cascade, which is a highly complicated process involving various pathways and biological events. Nonetheless, satisfactory therapeutic outcomes are rarely observed, since it is a great challenge to thwart this multi-phase process. Recent advances in nanotechnology-based drug delivery systems have shown great potential in the field of anti-metastasis, especially compared with conventional treatment methods, which are limited by serious side effects and poor efficacy. In this review, we summarized various factors involved in each phase of the metastatic cascade ranging from the metastasis initiation to colonization. Then we reviewed current approaches of targeting these factors to stifle the metastatic cascade, including modulating primary tumor microenvironment, targeting circulating tumor cells, regulating premetastatic niche and eliminating established metastasis. Additionally, we highlighted the multi-phase targeted drug delivery systems, which hold a better chance to inhibit metastasis. Besides, we demonstrated the limitation and future perspectives of nanomedicine-based anti-metastasis strategies.

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“…The circulating MDSC pool expands with cancer progression. 19 Primary tumors secrete factors and exosomes that direct MDSCs to distant sites, thereby elevating MDSC numbers at these sites before surgical resection. In some solid tumors, presurgery circulating MDSC levels correlate with cancer recurrence rates after tumor resection.…”

Section: Mdscs Persist In Distant Organs After Primary Tumor Resectiomentioning

confidence: 99%

Targeting Myeloid-Derived Suppressor Cells for Premetastatic Niche Disruption After Tumor Resection

et al. 2020

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Surgical resection is a common therapeutic option for primary solid tumors. However, high cancer recurrence and metastatic rates after resection are the main cause of cancer related mortalities. This implies the existence of a “fertile soil” following surgery that facilitates colonization by circulating cancer cells. Myeloid-derived suppressor cells (MDSCs) are essential for premetastatic niche formation, and may persist in distant organs for up to 2 weeks after surgery. These postsurgical persistent lung MDSCs exhibit stronger immunosuppression compared with presurgical MDSCs, suggesting that surgery enhances MDSC function. Surgical stress and trauma trigger the secretion of systemic inflammatory cytokines, which enhance MDSC mobilization and proliferation. Additionally, damage associated molecular patterns (DAMPs) directly activate MDSCs through pattern recognition receptor-mediated signals. Surgery also increases vascular permeability, induces an increase in lysyl oxidase and extracellular matrix remodeling in lungs, that enhances MDSC mobilization. Postsurgical therapies that inhibit the induction of premetastatic niches by MDSCs promote the long-term survival of patients. Cyclooxygenase-2 inhibitors and β-blockade, or their combination, may minimize the impact of surgical stress on MDSCs. Anti-DAMPs and associated inflammatory signaling inhibitors also are potential therapies. Existing therapies under tumor-bearing conditions, such as MDSCs depletion with low-dose chemotherapy or tyrosine kinase inhibitors, MDSCs differentiation using all-trans retinoic acid, and STAT3 inhibition merit clinical evaluation during the perioperative period. In addition, combining low-dose epigenetic drugs with chemokine receptors, reversing immunosuppression through the Enhanced Recovery After Surgery protocol, repairing vascular leakage, or inhibiting extracellular matrix remodeling also may enhance the long-term survival of curative resection patients.

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Lung resided monocytic myeloid-derived suppressor cells contribute to premetastatic niche formation by enhancing MMP-9 expression

Cited by 21 publications

References 41 publications

The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process

The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process

Emerging nanomedicine-based therapeutics for hematogenous metastatic cascade inhibition: Interfering with the crosstalk between “seed and soil”

Targeting Myeloid-Derived Suppressor Cells for Premetastatic Niche Disruption After Tumor Resection

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