Lung‐resident <i>γδ</i> T cells and their roles in lung diseases

Cheng, Min; Hu, Shilian

doi:10.1111/imm.12764

Cited by 90 publications

(83 citation statements)

References 96 publications

(90 reference statements)

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“…In addition to lung cancer, γδT cells are involved in several lung diseases including bacterial, viral and fungal infections, allergic disease, inflammation, and fibrosis (Cheng & Hu, 2017). IL-17A produced by lung-resident γδT cells suppresses allergic inflammation by inhibiting Th2-driven inflammation and eosinophil influx (Murdoch & Lloyd, 2010;de Oliveira Henriques & Penido, 2012).…”

Section: Discussionmentioning

confidence: 99%

Intrinsically altered lung‐resident γδT cells control lung melanoma by producing interleukin‐17A in the elderly

et al. 2020

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Cancer is an age-associated disease, potentially related to the altered immune system of elderly individuals. However, cancer has gradually decreased incidence in the eldest globally such as the most common lung cancer, the mechanisms of which remain to be elucidated. In this study, it was found that the number of lung-resident γδT cells was significantly increased with altered gene expression in aged mice (20-24 months) versus young mice (10-16 weeks). Aged lung Vγ4 + and Vγ6 + γδT cells predominantly produced interleukin-17A (IL-17A), resulting in increased levels in the serum and lungs. Moreover, the aged mice exhibited smaller tumors and reduced numbers of tumor foci in the lungs after challenge with intravenous injection of B16/F10 melanoma cells compared with the young mice. Aged lung Vγ4 + and Vγ6 + γδT cells were highly cytotoxic to B16/F10 melanoma cells with higher expression levels of CD103.The markedly longer survival of the challenged aged mice was dependent on γδT17 cells, since neutralization of IL-17A or depletion of indicated γδT cells significantly shortened the survival time. Consistently, supplementation of IL-17A significantly enhanced the survival time of young mice with lung melanoma. Furthermore, the antitumor activity of aged lung γδT17 cells was not affected by alterations in the load and composition of commensal microbiota, as demonstrated through co-housing of the aged and young mice. Intrinsically altered lung γδT17 cells underlying age-dependent changes control lung melanoma, which will help to better understand the lung cancer progression in the elderly and the potential use of γδT17 cells in anti-tumor immunotherapy.

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Section: Discussionmentioning

confidence: 99%

Intrinsically altered lung‐resident γδT cells control lung melanoma by producing interleukin‐17A in the elderly

et al. 2020

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“…γδ T cells derive from thymic precursors and migrate into tissues early during development where they then persist as tissue-resident cells. 139,140 These cells frequently express tissue-specific TCRs, which are invariant or closely related, resulting in distinguished roles for γδ T cells in different tissues. 140,141 Similar to MAIT cells, IFN-γ and IL-17 are produced by different γδ T cell subsets.…”

Section: Tissue-resident Unconventional T Cellsmentioning

confidence: 99%

“…139,140 These cells frequently express tissue-specific TCRs, which are invariant or closely related, resulting in distinguished roles for γδ T cells in different tissues. 140,141 Similar to MAIT cells, IFN-γ and IL-17 are produced by different γδ T cell subsets. 142,143 Dermal γδ T cells express the tissue-resident T cell markers CD69 and CD103 and additionally bear skin homing receptors and produce IL-17 and IL-22.…”

Section: Tissue-resident Unconventional T Cellsmentioning

confidence: 99%

Tissue-resident lymphocytes: from adaptive to innate immunity

et al. 2019

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Efficient immune responses against invading pathogens often involve coordination between cells from both the innate and adaptive immune systems. For multiple decades, it has been believed that CD8 + memory T cells and natural killer (NK) cells constantly and uniformly recirculate. Only recently was the existence of noncirculating memory T and NK cells that remain resident in the peripheral tissues, termed tissue-resident memory T (T RM) cells and tissue-resident NK (trNK) cells, observed in various organs owing to improved techniques. T RM cells populate a wide range of peripheral organs, including the skin, sensory ganglia, gut, lungs, brain, salivary glands, female reproductive tract, and others. Recent findings have demonstrated the existence of T RM in the secondary lymphoid organs (SLOs) as well, leading to revision of the classic theory that they exist only in peripheral organs. trNK cells have been identified in the uterus, skin, kidney, adipose tissue, and salivary glands. These tissue-resident lymphocytes do not recirculate in the blood or lymphatic system and often adopt a unique phenotype that is distinct from those of circulating immune cells. In this review, we will discuss the recent findings on the tissue residency of both innate and adaptive lymphocytes, with a particular focus on CD8 + memory T cells, and describe some advances regarding unconventional T cells (invariant NKT cells, mucosal-associated invariant T cells (MAIT), and γδ T cells) and the emerging family of trNK cells. Specifically, we will focus on the phenotypes and functions of these subsets and discuss their implications in anti-viral and anti-tumor immunity.

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“…S. mitis also leads to neutrophil recruitment and inflammation, macrophage chemotaxis, a higher secretion of immunological inhibitory cytokine IL-10, and an increased immune checkpoint PD-L1 expression, facilitating the cancer development and expansion [41]. Lung resident γδ T cells, and their either protective roles or pro-tumorigenic functions in cancer have been recently discovered [42]. A study has provided evidence that local lung microbiota (one of the most common genera was Streptococcus) can provoke inflammation and tumor cell proliferation, via lung resident γδ T cells activation, that release IL-17, after IL-1β and IL-23 induction in myeloid cells by these local microbiota [43].…”

Section: Discussionmentioning

confidence: 99%

Microbiota Core in Central Lung Cancer with Streptococcal Enrichment as a Possible Diagnostic Marker

Bello

Vengoechea

Ponce-Alonso

et al. 2020

Preprint

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Background: Dysbiosis has been scarcely explored in the respiratory tract with cancer. We aimed to define the bacterial and fungal microbiota of the bronchi in cancer versus a healthy state, also defining the microbiota core, and their correlation with that in saliva and feces; and to detect markers for the early diagnosis of central lung cancer. For this purpose, twenty-five patients with central lung cancer and sixteen healthy controls without antimicrobial intake during the previous month were recruited. Bacterial and fungi distribution was determined by massive sequencing in bronchial biopsies. Complex computational analysis was performed to define for the first time the lung microbiota core.Results: A greater abundance of Streptococcus, Rothia, Gemella and Lactobacillus distinguish the saliva of patients. Affected and contralateral bronchi of these patients have almost identical microbiota dominated by Streptococcus, whereas Pseudomonas was the major genera in controls. Oral and pulmonary ecosystems were significantly more similar in patients, probably due to microaspirations. Streptococcal bronchial abundance differentiates patients from controls by an ROC curve (90.9% sensitivity, 83.3% specificity, AUC=0.897). The mycobiome of controls (Candida) was significantly different from that of patients (Malassezia), with the cancer-affected bronchi similar to their saliva, but different from their contralateral bronchi. Conclusions: Central lung cancer is highly enriched with Streptococcus, and shows significantly differences in their composition from healthy subjects. Alterations are not restricted to the tumor tissue, and seem to be the consequence of microaspirations from the oral cavity. These findings could be useful in the screening and even diagnosis of this pathology.

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Lung‐resident γδ T cells and their roles in lung diseases

Cited by 90 publications

References 96 publications

Intrinsically altered lung‐resident γδT cells control lung melanoma by producing interleukin‐17A in the elderly

Intrinsically altered lung‐resident γδT cells control lung melanoma by producing interleukin‐17A in the elderly

Tissue-resident lymphocytes: from adaptive to innate immunity

Microbiota Core in Central Lung Cancer with Streptococcal Enrichment as a Possible Diagnostic Marker

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