Lung Transplantation and Precision Medicine

Beeckmans, Hanne; Sáez, Berta; Herck, Anke Van; Sacreas, Annelore; Kaes, Janne; Heigl, Tobias; Vanstapel, Arno; Ordies, Sofie; Frick, Anna Elisabeth; Verleden, Stijn E.; Verleden, Geert M.; Vos, Robin; Vanaudenaerde, Bart

doi:10.1007/978-3-030-31507-8_22

Cited by 3 publications

(1 citation statement)

References 91 publications

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“…As there is typically a higher chance of rejection after lung transplant, SLT recipients need life-long and intense immunosuppressive treatment to prevent graft rejection. Immunosuppressive regimen after LT most often involves a triple combination of corticosteroid, cyclosporine/tacrolimus, and azathioprine/mycophenolate mofetil[ 44 , 45 ].…”

Section: Post Slt Complications Related To Graft Functionmentioning

confidence: 99%

Factors affecting complications development and mortality after single lung transplant

Sekulovski¹,

Simonska²,

Peruhova³

et al. 2021

WJT

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Lung transplantation (LT) is a life-saving therapeutic procedure that prolongs survival in patients with end-stage lung disease. Furthermore, as a therapeutic option for high-risk candidates, single LT (SLT) can be feasible because the immediate morbidity and mortality after transplantation are lower compared to sequential single (double) LT (SSLTx). Still, the long-term overall survival is, in general, better for SSLTx. Despite the great success over the years, the early post-SLT period remains a perilous time for these patients. Patients who undergo SLT are predisposed to evolving early or late postoperative complications. This review emphasizes factors leading to post-SLT complications in the early and late periods including primary graft dysfunction and chronic lung allograft dysfunction, native lung complications, anastomosis complications, infections, cardiovascular, gastrointestinal, renal, and metabolite complications, and their association with morbidity and mortality in these patients. Furthermore, we discuss the incidence of malignancy after SLT and their correlation with immunosuppression therapy.

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Section: Post Slt Complications Related To Graft Functionmentioning

confidence: 99%