Lung Transplantation in Older Patients With Cystic Fibrosis: Analysis of UNOS Data

Clinical and demographic factors associated with post–lung transplantation survival in individuals with cystic fibrosis

“…An earlier study published in 2009 used United Network for Organ Sharing data from 1987 to 2007 and demonstrated that patients who underwent transplant at older ages (28-34 years and Z35 years of age) had a statistically significant reduction in risk of death compared with patients who underwent transplant between the ages of 7 and 20 years. 8 Several factors, such as sex, malnutrition, and CF-related diabetes (CFRD), have been shown to have a negative impact on health outcomes in the general CF population [9][10][11][12][13][14][15] ; however, their effects on the post-transplant population are unclear. For example, depending on the study, investigators found that individuals with CFRD have better survival posttransplant, 16,17 found that individuals with CFRD have an increased risk of death after lung transplant, 8 or found no association with post-transplant survival.…”

Impact Of Lung Allocation Score On Survival In Cystic Fibrosis Lung Transplant Recipients

“…These data support previous findings that have shown that older CF patients have improved survival outcomes with lung transplantation. 19,23 We, as others, speculate that the improved survival in older CF lung transplant recipients may be related to improved treatment adherence secondary to behavioral independence and emotional maturation in the older adult transplant recipient. 24 In our multivariable model, survival was also found to be negatively associated with nonprivate medical insurance status.…”

“…The top quintile of the cohort by LAS corresponded to a LAS near 50; for clarity this cut-off was chosen to describe a high-risk cohort (LAS ≥ 50), and a low-risk comparison group (LAS < 50) as modeled in previous studies. 6,19 We also examined LAS as a continuous variable, and as a variable rescaled in increments of 10, in order to provide clarity of hazard estimates. Survival was modeled using the Kaplan-Meier product limit estimator with statistical differences between survival curves assessed using the Mantel-Cox log-rank test.…”

Fibrosis quística en el adulto: experiencia de un centro de referencia nacional

“…En esta serie, en los pacientes a quienes se le realizó estudio genético, la frecuencia de esta mutación llega al 40,5%, cifra menor que la encontrada en la población norteamericana y europea 18 , situación que también fue descrita por Lay-Son y cols en la población chilena 17 . Es interesante el número de pacientes adultos con estudio genético negativo para las mutaciones estudiadas, lo que puede sugerir otras mutaciones menos comunes involucradas en manifestaciones de FQ con una mayor sobrevida.…”

“…En nuestra serie tres pacientes han sido trasplantados de pulmón, procedimiento que ha demostrado prolongar la sobrevida y mejorar la calidad de vida de los pacientes con FQ que tienen compromiso pulmonar avanzado 9,15,18 .…”