Lung Tumors

Popper, Helmut

doi:10.1007/978-3-662-50491-8_17

Pathology of Lung Disease 2016

DOI: 10.1007/978-3-662-50491-8_17

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Lung Tumors

Helmut Popper¹

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2017

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Organotypic Models of Lung Cancer

Pomerenke

2017

Current Topics in Microbiology and Immunology

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Human lung cancer is one of the leading causes of death worldwide, with nearly 2 million of new cases diagnosed each year, often too late for a successful therapeutic intervention. In this chapter, organotypic models of lung cancer will be reviewed. Ex vivo tissue explants, spheroids, organoids, and novel bioengineering approaches are currently being used to study human lung cancer. Although there is no ideal method that will fully recapitulate the complex human lung architecture, the three-dimensional (3D) organotypic models described here represent a major advance from classical two-dimensional (2D) tissue culture models. Organotypic tissue cultures are better at predicting in vivo tissue responses to anticancer drugs or carcinogenic toxins. In addition, there is also a possibility to use these systems as part of personalized medicine (e.g., to assist clinicians in selecting appropriate therapeutic choices based on individual patient-derived tissue responses to drugs in vitro). There is still a need for improvement in the 3D culture systems, such as automation for high-throughput testing and reduction of costs. However, given the large number of failed clinical trials due to safety or efficacy reasons, more attention should be given to these more physiologically relevant 3D organotypic tissue culture models.

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Organotypic Models of Lung Cancer

Pomerenke

2017

Current Topics in Microbiology and Immunology

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Lung Tumors

Cited by 1 publication

References 494 publications

Organotypic Models of Lung Cancer

Organotypic Models of Lung Cancer

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