Lung Ultrasound for Predicting the Respiratory Outcome in Patients with Bronchopulmonary Dysplasia

Hoshino, Yusuke; Arai, Junichi; Miura, Rena; Takeuchi, Syusuke; Yukitake, Yoshiya; Kajikawa, Daigo; Kamakura, Tae; Horigome, Hitoshi

doi:10.1055/s-0040-1721848

Cited by 16 publications

(19 citation statements)

References 41 publications

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“…A contemporary definition of BPD that correlates with respiratory morbidity in childhood is needed [31]. Also, a new lung ultrasound technique for predicting the respiratory outcome in patients with BPD can be used instead of HRCT [32].…”

Section: Discussionmentioning

confidence: 99%

High-Resolution Computed Tomography Scores in Cases of Bronchopulmonary Dysplasia

Akcan

Oygucu

Arslan

et al. 2022

BioMed Research International

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Background. Bronchopulmonary dysplasia (BPD) carries a risk of long-term pulmonary sequelae. High-resolution computed tomography (HRCT) is a method of detecting such structural changes. This study is aimed at characterizing structural abnormalities associated with BPD and at evaluating the clinical findings in the newborn period associated with HRCT scores. Methods. 28 patients born with a mean gestation age of 30 ± 2.9 weeks and diagnosed as BPD in their neonatal period were reevaluated when they were between the postnatal ages of 6 and 12 months. HRCT was performed in 20 patients with a history of moderate and severe BPD. Scans were interpreted by one radiologist using a scoring system. Results. Patients were 9.8 ± 2.3 months at the time of reevaluation. The average HRCT score of patients was, respectively, 7.20 ± 4.05 with moderate and 7.40 ± 2.84 with severe BPD. The difference between them was not significant ( p = 0.620 ). When moderate and severe groups were collected as a whole on the basis of physical findings and drug treatment, 6 had normal physical examination findings, no oxygen and no drug requirement; 14 had at least one finding at the time of reevaluation. No significant difference was detected in terms of HRCT score between the two groups ( 6.50 ± 3.83 versus 7.64 ± 3.30 ). Conclusions. More studies are needed in terms of the role of HRCT in the assessment of BPD prognosis. A contemporary definition of BPD that correlates with respiratory morbidity in childhood is needed. Also, a new lung ultrasound technique for predicting the respiratory outcome in patients with BPD can be used instead of HRCT.

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Section: Discussionmentioning

confidence: 99%

High-Resolution Computed Tomography Scores in Cases of Bronchopulmonary Dysplasia

Akcan

Oygucu

Arslan

et al. 2022

BioMed Research International

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“…First, the scoring of LUS images is not complicated. Recently, a LUS scoring system has been used for the diagnosis and management of respiratory distress syndrome [26][27][28][29][30][31] , predicting the development of BPD [32][33][34] , and evaluating pulmonary water content 35 . In contrast, radiographic evaluation is subjective, which minimizes its generalizability and reproducibility 36,37 .…”

Section: Discussionmentioning

confidence: 99%

Serial Lung Ultrasound for the Evaluation of Gravity-Induced Lung Injuries in Very Preterm Infants

Hoshino

Arai

Hirono

et al. 2022

Preprint

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Background: Gravity affects the distribution of lung injuries due to gravity-induced nonhomogeneous ventilation leading to lung collapse and subsequently non-uniform lung lesions. Moreover, lung injury gradients gradually develop over time. However, changes in injury distribution after birth have not been investigated in very preterm infants. Methods: Preterm infants of less than 32 weeks’ gestational age were included in this prospective observational study. Gravity-dependent lungs (DL) were defined as dorsal lungs in a supine position or ventral lungs in a prone position, and non-dependent lungs (NDL) were defined as ventral lungs in a supine position or dorsal lungs in a prone position. Infants were assessed using lung ultrasound (LUS), which was performed on days 7, 14, 21, and 28 post-birth. Each anterior and posterior lung was scanned and received an LUS score of 0–3 points. LUS scores of the DL and NDL were compared. Total LUS scores were provided using a 0–6 point scale, which was obtained by adding the scores for each region of each lung. Results: Eighty–eight patients were enrolled in this study. On days 7, 14, and 21, LUS scores between the DL and NDL groups were significantly different (day 7, P = 0.01; day 14, P < 0.001; and day 21, P = 0.003). However, on day 28, there was no significant difference between groups (P = 0.064). Conclusions: LUS can be used to detect gravity-induced lung injury gradients in very preterm infants. Moreover, LUS revealed a trend of gradient improvement over time.

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“…In most of the studies carried out to date, LUS were shown to be able to predict the development of BPD as early as 7-14 days of life, with a predictive cut-off value ranging between 4 and 10. 17, [30][31][32][33][34][35][36][37] Although BPD is a disease characterized by a non homogeneous lung picture 41 with particular involvement of the gravity-dependent areas, 42 the inclusion of posterior areas in the LUS does not seem to improve the predictive characteristics as demonstrated by Alonso-Ojembarrena et al 36 and in the recent meta-analysis published by Pezza et al 43 A novel approach was proposed by Raimondi et al who developed a logistic regression model to describe the interaction between GA and LUS in predicting BPD. 17 Similar results were obtained from the model proposed by Aldecoa Bilbao et al 37 These models had a higher predictive capacity compared to the LUS alone.…”

Section: Lung Ultrasound Score and Prediction Of Bronchopulmonary Dys...mentioning

confidence: 99%

Lung ultrasound scores in neonatal clinical practice: A narrative review of the literature

Corsini

Ciarcià

Ficial

et al. 2022

Pediatric Pulmonology

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Lung ultrasound (LU) has in recent years increasingly been used as a point-of-care method. Initially, LU was used as a so-called descriptive diagnostic method for neonatal respiratory diseases. Instead, this review article focuses on the use of LU as a "functional" tool using classification of findings in patterns or using semiquantitative scores. We review and describe the evidence that led to the implementation of LU in predicting the need for surfactant replacement therapy in preterm infants and in the identification of newborns at risk of developing bronchopulmonary dysplasia. LU appears to be a very promising method for the future of clinical management of newborns in both acute and chronic phases of pulmonary pathologies related to prematurity. However, further studies are needed to define its role before full implementation.

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Lung Ultrasound for Predicting the Respiratory Outcome in Patients with Bronchopulmonary Dysplasia

Cited by 16 publications

References 41 publications

High-Resolution Computed Tomography Scores in Cases of Bronchopulmonary Dysplasia

High-Resolution Computed Tomography Scores in Cases of Bronchopulmonary Dysplasia

Serial Lung Ultrasound for the Evaluation of Gravity-Induced Lung Injuries in Very Preterm Infants

Lung ultrasound scores in neonatal clinical practice: A narrative review of the literature

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