Lung volume and the response to high volume strategy, high frequency oscillation

Abstract

Lung volume prior to transfer to high volume strategy HFO might be helpful to guide oscillatory settings, but is a poor predictor of the response to high volume strategy HFO.

Prediction of respiratory failure in late-preterm infants with respiratory distress at birth

“…In preterm neonates with RDS, the A-aDO 2 and a/A ratio have been successfully used to quantify disease severity, compare different ventilation strategies, and predict extubation failure [5,13,14,23,26]. It has been also suggested that these parameters may be better predictors of the short-and long-term outcomes than other variables, such as birth weight, gestational age, Apgar score, maximal ventilator settings, maximum FiO 2 , or maximum PaCO 2 [24].…”

“…In a recent study, it has been suggested that the prediction of the need for ventilation in near-term neonates can be based on the oxygen requirement within the first hours of age, with a reasonable sensitivity and specificity [17]. The FiO 2 represents a simple and readily available index; however, it is operator-dependent [3] and has been shown to be a less effective predictor in comparison to other indices of respiratory failure in neonates [5,13,23,24,26].…”

“…Several indices, such as the alveolar-arterial oxygen tension difference (A-aDO 2 ), arterial to alveolar oxygen tension ratio (a/A ratio), and partial arterial oxygen tension to inspired oxygen fraction ratio (PaO 2 /FiO 2 ), have been used to quantify the severity of respiratory failure, compare treatment modalities, and assess short-and long-term outcomes in ventilated neonates [5,13,14,23,24,26]. It has been suggested that these indices may be more objective measures of respiratory compromise than commonly used parameters such as inspired oxygen fraction (FiO 2 ), partial arterial oxygen tension (PaO 2 ), and partial arterial carbon dioxide tension (PaCO 2 ) [3,10,19,24].…”

An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation

“…At 11-14 years, the UKOS cohort was re-examined and those supported by HFOV in the neonatal period had superior lung function (Zivanovic et al, 2014). During HFOV, much smaller tidal volumes are delivered than during CMV (Dimitriou et al, 2004).…”

In vitro assessment of proportional assist ventilation

“…Subsequently, pressure support ventilation has been introduced, during which the infant's respiratory efforts determine not only the onset but also the termination of ventilator inflation. This has been shown to reduce asynchrony3 but to date not BPD 4…”