Lungenfibrosen

Abstract

A new classification of the idiopathic interstitial pneumonia has recently been proposed, defining idiopathic pulmonary fibrosis (IPF) more rigorously and in contrast to further subentities. The new classification is of prognostic and clinical relevance. Diagnosis requires a combined clinical, radiological and pathological effort. In patients with characteristic clinical and HR-CT findings, the diagnosis of IPF can be made with sufficient confidence without surgical lung biopsy. Recent evidence suggests that the primary pathogenetic event in IPF involves epithelial injury and abnormal wound heeling. This explains the ineffectiveness of the usual anti-inflammatory therapy in the majority of patients. Since no antifibrotic drugs are available at present, the recommended standard therapy is a combination of prednisone with azathioprine or cyclophosphamide. New antifibrotic molecules are already tested in clinical trials.

Classification and Pathological Diagnosis of Idiopathic Interstitial Pneumonia

“…The plain Bayesian algorithm is simple to use and works well in various types of studies, and it appears in a large number of studies, for example, research on text classification based on the plain Bayesian approach [ 9 ], research on semantic annotation combining the plain Bayesian algorithm with Bootstrapping method [ 10 ], and research on improving the plain Bayesian algorithm and applying it to intrusion detection [ 11 ]. In addition, good suggestions have been shown in combination with other algorithms for application [ 3 , 11 – 13 ].…”

“…In terms of lesion progression, all types show lesions at the same stage, except for UIP, which shows inconsistent progression (i.e., intermingling of old and new lesions and near-normal lung tissue between lesions). DIP is mainly characterized by diffuse intra-alveolar macrophage accumulation, while RBILD has similar pathological changes to DIP, except that the lesions are relatively confined to the respiratory [ 13 ]. Pathological changes of RBILD are similar to those of DIP, except that the lesions are relatively confined to the respiratory bronchi and their surrounding air space, with a distinctive respiratory bronchiectasis.…”