Lungs from polytrauma donors with significant chest trauma can be safely used for transplantation

Schwarz, Štefan; Rahimi, Nina; Kifjak, Daria; Frommlet, Florian; Benazzo, Alberto; Jaksch, Péter; Klepetko, Walter; Höetzenecker, Konrad; Muraközy, G.; Lambers, Christopher; Hoda, Mir Alireza; Moser, Bernhard; Matilla, José Ramon; Láng, György; Taghavi, Shahrokh

doi:10.1016/j.jtcvs.2020.10.150

Cited by 13 publications

(5 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Questions remain however, regarding the limits of acceptability, as to what degree “extended-criteria” donor lungs can be used for transplantation without compromising recipient outcomes. Retrospective analyses have already demonstrated no adverse outcomes when using donor lungs with acute pulmonary embolism ( 17 , 18 ) impaired oxygenation ( 19 , 20 ), or contusion ( 21 ). Regarding donor age, multiple analyses have shown good results for lungs from donors >55 years of age ( 22 , 23 ) however, the upper donor age limit in lung transplantation remains under discussion.…”

Section: Discussionmentioning

confidence: 99%

Lungs From Donors ≥70 Years of Age for Transplantation—Do Long-Term Outcomes Justify Their Use?

Sommer

Franz²,

Aburahma³

et al. 2023

Transpl Int

View full text Add to dashboard Cite

Donor shortages have led transplant centers to extend their criteria for lung donors. Accepting lung donors ≥70 years of age has previously shown good short-term outcomes; however, no mid- and long-term outcome data on these extended criteria donors has been published to date. In this study, all patients who underwent lung transplantation between 06/2010 and 12/2019 were included in the analysis, and the outcomes were compared between patients receiving organs from donors <70 years of age and patients transplanted with lungs from donors ≥70 years of age. Among the 1,168 lung-transplanted patients, 62 patients received lungs from donors ≥70 years of age. The recipient age of those receiving older organs was significantly higher, and they were more likely to suffer from obstructive lung disease. Older donors were exposed to significantly shorter periods of mechanical ventilation prior to donation, had higher Horowitz indices, and were less likely to have smoked. The postoperative time on mechanical ventilation, time on ICU, and total hospital stay were comparable. The overall survival as well as CLAD-free survival showed no differences between both groups in the follow-up period. Utilization of lungs from donors ≥70 years of age leads to excellent mid- and long-term results that are similar to organs from younger donors when the organs from older donors are carefully preselected.

show abstract

Section: Discussionmentioning

confidence: 99%

Lungs From Donors ≥70 Years of Age for Transplantation—Do Long-Term Outcomes Justify Their Use?

Sommer

Franz²,

Aburahma³

et al. 2023

Transpl Int

View full text Add to dashboard Cite

show abstract

“…However, this topic has garnered recent attention to minimize loss of allografts from the donor pool. A 2022 study examined this in detail, which demonstrated no difference in PGD3 at 72 hours, duration of ventilation, and long-term graft survival in patients who received allografts with pulmonary contusions compared to those who did not ( 32 , 33 ). Further research is needed in this area to examine whether the extent of contusion serves as an effect modifier and what subset of contused lungs can safely be used to expand the donor pool.…”

Section: Donor Risk Factors For Development Of Pgdmentioning

confidence: 99%

Donor and recipient risk factors for the development of primary graft dysfunction following lung transplantation

Jenkins,

Verdiner,

Omar

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Primary Graft Dysfunction (PGD) is a major cause of both short-term and long-term morbidity and mortality following lung transplantation. Various donor, recipient, and technical risk factors have been previously identified as being associated with the development of PGD. Here, we present a comprehensive review of the current literature as it pertains to PGD following lung transplantation, as well as discussing current strategies to mitigate PGD and future directions. We will pay special attention to recent advances in lung transplantation such as ex-vivo lung perfusion, thoracoabdominal normothermic regional perfusion, and up-to-date literature published in the interim since the 2016 ISHLT consensus statement on PGD and the COVID-19 pandemic.

show abstract

“…Most common manifestation of blunt trauma is pulmonary contusion. Oftentimes, the patients require chest tube insertion for pneumothorax at the time of initial presentation; however, this should not preclude from a donation in many cases as majority of small lung injuries heal in 24-48 h of initial presentation and air leak can no longer be observed in the chest tube [20]. Persistent pneumothorax, subcutaneous emphysema, or air leak may adversely affect suitability.…”

Section: Traumamentioning

confidence: 99%

“…A careful intraoperative evaluation at the time of procurement is very important in this situation. In carefully selected cases, the outcomes are acceptable [20]. Massive blood transfusion and disseminated intravascular coagulation (DIC) is a frequent accompaniment of significant head injury, occurring up to 28% of all organ donors [21].…”

Section: Traumamentioning

confidence: 99%

Donor quality assessment and size match in lung transplantation

Mangukia

Shigemura

Brann

et al. 2021

Indian J Thorac Cardiovasc Surg

View full text Add to dashboard Cite

show abstract

Lungs from polytrauma donors with significant chest trauma can be safely used for transplantation

Cited by 13 publications

References 37 publications

Lungs From Donors ≥70 Years of Age for Transplantation—Do Long-Term Outcomes Justify Their Use?

Lungs From Donors ≥70 Years of Age for Transplantation—Do Long-Term Outcomes Justify Their Use?

Donor and recipient risk factors for the development of primary graft dysfunction following lung transplantation

Donor quality assessment and size match in lung transplantation

Contact Info

Product

Resources

About