Lungs: Remote inflammatory target of systemic cadmium administration in rats

Kataranovski, Milena; Mirkov, Ivana; Belij, Sandra; Nikolić, Miroslav; Zolotarevski, Lidija; Ćirić, Danica; Kataranovski, Dragan

doi:10.1016/j.etap.2009.04.008

Cited by 26 publications

(14 citation statements)

References 29 publications

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“…Intraperitoneal injection of 1 mg Cd/kg (the dose showed in our previous experiments to be sublethal and to exert immunomodulatory effects on leukocytes of distant targets such as lungs (Kataranovski et al, 2009a) and on peripheral blood leukocytes (Djokic et al, 2014a,b;Kataranovski et al, 1998) resulted in significant accumulation of Cd in blood, spleen, beside liver and kidneys (Table 2). Increase (P < 0.001) in numbers of peripheral blood leukocytes was observed in cadmium-treated rats (25.3 AE 3.9 Â 10 9 /l) compared to 8.8 AE 1.5 Â 10 9 /l in controls.…”

Section: General Considerationsmentioning

confidence: 89%

Acute cadmium administration to rats exerts both immunosuppressive and proinflammatory effects in spleen

et al. 2014

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Section: General Considerationsmentioning

confidence: 89%

Acute cadmium administration to rats exerts both immunosuppressive and proinflammatory effects in spleen

et al. 2014

Self Cite

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“…Statistically significant increase in IL-6 mRNA was detected with 5 and 10 μM CdCl 2 only after a 3-hour treatment (Souza et al, 2004). In another study, interleukin-6 cell production was measured in cultures of lung cells of rats treated with cadmium (Kataranovski et al, 2009). The authors demonstrated increased spontaneous IL-6 production in cultures of cells from cadmium treated rats (0.5 and 1 mg Cd/kg b.w.)…”

Section: Cadmium and Il-6mentioning

confidence: 96%

“…The authors demonstrated increased spontaneous IL-6 production in cultures of cells from cadmium treated rats (0.5 and 1 mg Cd/kg b.w.) (Kataranovski et al, 2009). Lag and coworkers examined cadmium effects on different cellular systems relevant for lung toxicity: human M1 fibroblast cultures and rat primary lung cell cultures, i.e.…”

Section: Cadmium and Il-6mentioning

confidence: 99%

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Pro-inflammatory properties of cadmium.

Olszowski

Baranowska-Bosiacka²,

Gutowska³

et al. 2012

Acta Biochim Pol

142

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Cadmium is a toxic and carcinogenic heavy metal that nowadays constitutes a serious environmental health problem. The aim of this study is to review the effects of cadmium on selected inflammatory mediators and markers, such as NF-κB and AP-1 transcription factors, IL-6, TNF-α, IL-1β cytokines, IL-8 or MIP-2 chemokine, MPO, iNOS, MMPs and COX-2 enzymes, PGE 2 (product of COX-2 enzyme), ICAM-1, VCAM-1 and PECAM-1 adhesion molecules, and CRP. The research strategy identified articles available in Medline, published between 1998 and 2012; we included both in vivo and in vitro studies carried out on humans and rodents. Most of the reviewed research findings suggest that cadmium in micromolar concentrations (especially in the 1-10 μM range) causes up-regulation of the mediators and markers of inflammation, and appears to have pro-inflammatory properties. However, it is worth mentioning that a contradictory or even opposite hypothesis exists, which suggests cadmium to be an anti-inflammatory factor. Further research including detailed histological analyses should solve this discrepancy. Nevertheless, it appears that the main reason for these contradictory findings is the experimental setup: different biological systems analyzed and different doses of cadmium applied.

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“…Cd is a commercially important metal used in NiCd batteries, plating, pigments and plastics (3)(4)(5). Earlier occupational toxicities from Cd have been largely eliminated by occupational hygiene, and tobacco use remains as a major avoidable source of exposure.…”

Section: Introductionmentioning

confidence: 99%

Low-dose cadmium potentiates lung inflammatory response to 2009 pandemic H1N1 influenza virus in mice

Chandler

et al. 2018

Preprint

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Cadmium (Cd) is a toxic, pro-inflammatory metal ubiquitous in the diet that accumulates in body organs due to inefficient elimination. Responses to influenza virus infection are variable, particularly severity of pneumonia. We used a murine model of chronic low-dose oral exposure to Cd to test if increased lung tissue Cd worsened inflammation in response to sub-lethal H1N1 infection. Using histopathology and flow cytometry, we observed increased lung inflammation in Cd-treated mice given H1N1 compared to H1N1 alone, including neutrophils, monocytes, T lymphocytes and dendritic cells. Lung genetic responses to infection (increasing TNF-α, interferon and complement, and decreasing myogenesis) were also exacerbated. To reveal the organization of a network structure, pinpointing molecules critical to Cd-altered lung function, global correlations were made for immune cell counts, leading edge gene transcripts and metabolites. This revealed that Cd increased correlation of myeloid immune cells with proinflammatory genes, particularly interferon-γ and metabolites. Together, the results show that Cd burden in mice increased inflammation in response to sub-lethal H1N1 challenge, which was coordinated by genetic and metabolic responses, and could provide new targets for intervention against lethal inflammatory pathology of clinical H1N1 infection.

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Lungs: Remote inflammatory target of systemic cadmium administration in rats

Cited by 26 publications

References 29 publications

Acute cadmium administration to rats exerts both immunosuppressive and proinflammatory effects in spleen

Acute cadmium administration to rats exerts both immunosuppressive and proinflammatory effects in spleen

Pro-inflammatory properties of cadmium.

Low-dose cadmium potentiates lung inflammatory response to 2009 pandemic H1N1 influenza virus in mice

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