Lupus anticoagulant: An analysis of the clinical and laboratory features of 219 cases

Abstract

To define clinical and laboratory characteristics of the lupus anticoagulant (LA), we reviewed our experience (219 subjects). Subjects were divided into group A, those with the LA and the diagnosis of lupus erythematosus, group B, those with the LA but nonlupus diagnoses, and group C, those with drug-related lupus syndromes. The typical laboratory findings consisted of a prolonged and inhibited plasma clot time (an average of 1.9 times control time) which was proportionately more prolonged than the partial thromboplastin time or activated partial thromboplastin time (APTT) (average 1.3 times control). Ninety-eight percent had a prolonged plasma clot time and 94% had a prolonged partial thromboplastin time. The prothrombin and thrombin times were prolonged in 33 and 25% of subjects, respectively. Washed platelets shortened the APTT in the 22 subjects so tested. Monoclonal protein peaks were seen in 7% of patients. Seventeen episodes of bleeding were observed, but in all but one instance there was another hemostatic defect present. In the 18 patients who underwent major operations, there were no hemorrhagic complications. Fifty-eight episodes of thrombosis were observed with the same incidence in group A (25%) as in group B (26%). Bleeding is rare with the LA but thrombosis is common even without SLE and lupuslike syndromes. The plasma clot time in platelet-rich plasma is more prolonged, and in our experience, is more sensitive in detecting the lupus anticoagulant than is the partial thromboplastin time.

Lupus Anticoagulants and Anticardiolipin Antibodies in Indian Women with Spontaneous, Recurrent Fetal Loss

“…It has been reported that LA does not prolong PT due to a high concentration of phospholipid in the thromboplastin reagent [23]. APTT is a common screening test for LA though it is reported to be insufficiently sensitive [24]. In the present study 3 of 8 (18.7 %) patients with prolonged APTT were confirmed to be LA positive.…”

The clonal analysis of anticardiolipin antibodies in a single patient with primary antiphospholipid syndrome reveals an extreme antibody heterogeneity

“…[2][3][4] The mechanism of the characteristic prothrombotic state related to aPLs during APS is still under debate. 5 Much of it is related to the definition of the precise nature of aPL specificity, which remains unclear because of the number of possible antigenic targets discovered over the last few years.…”

Trombo biventricular e fibrose endomiocárdica na síndrome antifosfolípide

“…Venous thromboembolism is the most common clinical presentation of APS, occurring in 30-70% of patients 3 . In relation to arteries, the carotid arteries are the main affected vessels and their thrombi may develop into a stroke.…”

“…The cardiac alterations are frequently observed, especially valvular heart disease (thickening and vegetations) and coronary artery disease (CAD) [2][3][4] ; the presence of thrombi has been also reported 5 . However, myocardial involvement is rarely described in this pathology 6 .…”