Lupus Anticoagulant Testing: Dilute Prothrombin Time (dPT)

Testing for the lupus anticoagulant: the good, the bad, and the ugly

“…Additional tests are used in some situations, for example, when there is a strong suspicion of LA but aPTT and dRVVT are inconclusive or if there is assay interference (eg, from clinical anticoagulants). Such tests include the Taipan snake venom time (TSVT), the Ecarin clotting time (ECT), and the dilute prothrombin time (PT) [ [18] , [19] , [20] ]. Instead of the aPTT, an alternative sensitive assay based on a similar principle (ie, contact activation) is the silica clotting time [ 16 ].…”

Classification Criteria for the Antiphospholipid Syndrome: Not the Same as Diagnostic Criteria for Antiphospholipid Syndrome

“…Finally, there are a large number of LA and aPL assays that may have value for diagnosing APS that are not as yet listed in the classification criteria; in particular, assays for antiphosphatidylserine/prothrombin antibodies and anti-domain I of β2-glycoprotein I, 16 17 18 19 or those for Taipan snake venom time, ecarin time, and dilute prothrombin time for LA. 20 21 22…”