2014
DOI: 10.5455/2320-6012.ijrms20140275
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Lupus cystitis with hydroureteronephrosis in a young female with lupus nephritis

Abstract: Systemic lupus erythematosus is an autoimmune, multisystem disorder. Lupus nephritis is a common manifestation of SLE. Though rare, SLE may also involve lower urinary tract in the form of lupus cystitis with associated complications like hydroureteronephrosis. Lupus cystitis may present with gastro intestinal (GI) symptoms as the initial manifestation. The case reported herein is concerned with concomitant lupus nephritis and cystitis in a young female who also had associated GI symptoms and hydroureteronephro… Show more

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“…The main finding in lupus cystitis is an increased thickness of the bladder wall due to chronic interstitial cystitis, with pathological examination showing deposition of immune-mediated complex in the bladder wall [ 7 , 11 ]. Ultrasonographic examination and a computed tomography scan may reveal bilateral hydronephrosis or hydroureteronephrosis in addition to bladder wall thickening [ 12 , 13 ]. Fibrosis of the ureterovesical junction and edema of the bladder wall caused by deposition of immune-mediated complex leads to decreased bladder capacity and detrusor muscle spasm, and the ensuing vesicoureteral obstruction and reflux has been suggested to be the cause of the hydronephrosis in our patient.…”
Section: Discussionmentioning
confidence: 99%
“…The main finding in lupus cystitis is an increased thickness of the bladder wall due to chronic interstitial cystitis, with pathological examination showing deposition of immune-mediated complex in the bladder wall [ 7 , 11 ]. Ultrasonographic examination and a computed tomography scan may reveal bilateral hydronephrosis or hydroureteronephrosis in addition to bladder wall thickening [ 12 , 13 ]. Fibrosis of the ureterovesical junction and edema of the bladder wall caused by deposition of immune-mediated complex leads to decreased bladder capacity and detrusor muscle spasm, and the ensuing vesicoureteral obstruction and reflux has been suggested to be the cause of the hydronephrosis in our patient.…”
Section: Discussionmentioning
confidence: 99%