Lupus eritematoso neonatal

Muiños, Elvira León; Monteagudo‐Sánchez, Benigno; González, J.E. Luaces; Santiago, J. García

doi:10.1157/13124905

Cited by 9 publications

(4 citation statements)

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“…[7] Environmental factors and fetal genetics also play a role in pathogenesis, which makes some children sensitive to the presence of these maternal autoantibodies. [1][2][3][4][5][6][7][8] The true incidence has not yet been defined due to underdiagnosis and misdiagnosis. However, it affects approximately 1 in 12,500 to 20,000 newborns and can affect all ethnic groups, with female predominance.…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, the healthy mothers of these children are at high risk of developing connective tissue disease in the future with a 20% chance of recurrence in three consecutive pregnancies. [5,6] The clinical picture of the disease is multiform; the symptoms can be temporary (for example skin lesions) or include organ changes such as hematological, hepatological, or irreversible disorders, such as congenital heart block. (CHB).…”

Section: Discussionmentioning

confidence: 99%

“…they may be completely asymptomatic at the time of childbirth. [5,6] In Morocco, few studies have been published; for this reason, our paper outlines the clinical and paraclinical particularities, the therapeutic management, and the prognosis of fifteen newborns with NLE, relating them to other studies in the scientific literature in order to contribute to the improvement of the management of this pathology.…”

Section: Introductionmentioning

confidence: 99%

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Neonatal Lupus Erythematosus: Fifteen Cases Report and Review of Literature

Lehlimi,

Hayat,

Derrak

et al. 2024

AJP

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Neonatal lupus erythematosus (NLE) is a rare autoimmune disease caused by the transplacental transfer of maternal autoantibodies, especially anti-Ro/SSA, anti-La/SSB, and anti-U1RNP. The objective of this study was to review the clinical, paraclinical, and therapeutic management of fifteen newborns admitted to a neonatal reanimation center at Children's Hospital A. Harouchi, Ibn Rochd University Hospital Centre. Results: Among these fifteen newborns, two categories were observed: the first category included eleven newborns of known lupus mothers in whom the electrocardiogram systematically requested came back normal. Skin lesions or biological abnormalities were found in some of these newborns, while others were completely asymptomatic. Simple clinical and paraclinical monitoring was performed, and the short-and long-term evolution was favorable. The second category included four newborns of mothers initially not known to have lupus but in whom the diagnosis of SLE was established after a maternal check-up because of neonatal bradycardia or suggestive skin lesions. In these four newborns, the systematic ECG revealed complete atrioventricular block in two and right bundle branch block in another. The cardiac ultrasound revealed cardiac malformations in three newborns. The systematic biological assessment showed abnormalities in two, and skin lesions were found in two newborns. In the cases of BAVc and BBD, the treatment consisted of pacemaker implantation, whereas simple monitoring was carried out in the newborn with cutaneous lesions. In conclusion, the clinical manifestations of NLE are varied; they may include temporary onset or irreversible symptoms such as congenital heart block (CHB), particularly third-degree heart block, which is the most serious complication of NLE because of its high morbidity and mortality rate and requires strict monitoring of all mothers with known lupus or with risk factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neonatal Lupus Erythematosus: Fifteen Cases Report and Review of Literature

Lehlimi,

Hayat,

Derrak

et al. 2024

AJP

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“…El diagnóstico requiere un alto índice de sospecha 8 , y es importante tanto para los niños como para las madres ya que, en estas, puede evolucionar a una enfermedad del tejido conectivo hasta en un 50% de casos y con frecuencia están asintomáticas en el momento del diagnóstico en el neonato.…”

Section: Introductionunclassified