Lupus érythémateux disséminé survenant après 65 ans

Gaujard, Sylvain; Broussolle, C.; Cathébras, P.; Dupond, J.L.; Massot, C; Ninet, J.; Perrot, H; Durand, D. Vital; Rousset, H.

doi:10.1016/s0248-8663(03)00052-3

Cited by 23 publications

(5 citation statements)

References 28 publications

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“…47 This may be due to the clinical impression of many clinicians that LE is a disease of childbearing age, the more insidious course of late onset SLE, and the lack of specificity of the symptoms of the disease in a population with multiple ailments. 11,36,47 Elderly patients also have fewer skin symptoms, such as malar rash and photosensitivity, 47 and a lower incidence of arthritis and nephropathy. 48 Therefore, it is desirable that any set of revised criteria is evaluated in a sizeable group of late onset LE, as well as in a pediatric population.…”

Section: Children and Elderlymentioning

confidence: 99%

Dermatology position paper on the revision of the 1982 ACR criteria for systemic lupus erythematosus

Albrecht

Berlin

Braverman

et al. 2004

Lupus

103

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The 1982 ACR classification criteria have become de facto diagnostic criteria for systemic lupus erythematosus (SLE), but a review of the criteria is necessary to include recent diagnostic tests. The criteria were not developed with the help of dermatologists, and assign too much weight to the skin as one expression of a multiorgan disease. Consequently, patients with skin diseases are classified as SLE based mostly on skin symptoms. We discuss specific problems with each dermatologic criterion, but changes must await a new study. We suggest the following guidelines for such a study, aimed at revision of the criteria. 1) The SLE patient group should be recruited in part by dermatologists. 2) The study should evaluate an appropriate international ethnic/racial mix, including late onset SLE as well as pediatric patients. 3) All patients should have current laboratory and clinical evaluations, as suggested in the paper, to assure the criteria can be up-to-date. This includes anti-SS-A and anti-SS-B antibodies and skin biopsies for suspected cutaneous lupus erythematosus except for nonscarring alopecia and oral ulcers. 4) The study should be based on a series of transparent power calculations. 5) The control groups should represent relevant differential diagnoses in numbers large enough to assess diagnostic problems that might be specific to these differential diagnoses. In order to demonstrate specificity of the criteria with a 95% confidence interval between 90 and 100%, each control group of the above should have at least 73 patients.

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Section: Children and Elderlymentioning

confidence: 99%

Dermatology position paper on the revision of the 1982 ACR criteria for systemic lupus erythematosus

Albrecht

Berlin

Braverman

et al. 2004

Lupus

103

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“…The prevalence of serositis, lung involvement and Sjögren’s syndrome were observed more often. The prognosis in older patients is relatively good [9]. In our case, no aggravation of SLE was observed with the administration of chloroquine.…”

Section: Discussionmentioning

confidence: 52%

“…In severe cases of SLE, biological drugs targeting specific pathways (T-B lymphocytes interactions, cytokines and complements) have been proposed as new therapeutic approach for SLE [10]. This is especially important for early-onset SLE patients, in elderly patients, the less aggression clinical evolution, comorbidities and concomitant therapies may limit the therapeutic options for SLE [8,9]. …”

Section: Discussionmentioning

confidence: 99%

Late–onset systemic lupus erythematosus-associated primary biliary cirrhosis

Hammami¹,

Chaabane²,

Mahmoudi³

et al. 2013

Int Arch Med

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BackgroundThe development of Primary Biliary Cirrhosis (PBC) during the course of Systemic Lupus Erythematosus (SLE) is extremely rare. We report the case of a geriatric woman who was diagnosed with SLE at 69 years of age then with primary biliary cirrhosis one year later.Case presentationA 70-years-old woman, who had been diagnosed with SLE at 69 years, was admitted for further examination of liver dysfunction. PBC was confirmed based on elevated serum levels of transaminase, high levels of antimitochondrial antibodies and following a liver biopsy. The oral administration of ursodeoxycholic acid stabilized the liver dysfunction.ConclusionWe described an original case report of elderly patient with coexisting PBC and SLE. To date, according to the best of our knowledge, there have been few case reports of SLE/PBC co-occurrence. The aetiology of this complex remains unknown, autoimmune mechanisms, environmental and genetic factors are considered important in the susceptibility to both diseases. Osteopontin might play an important role.

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“…In older adults, diagnosis is often delayed because of the slow onset of disease, non-specific manifestations during the early stages of illness, and the low prevalence of SLE in older populations. 4,5 Late-onset SLE and other rheumatological diseases should always be considered in older adults who present with nonspecific symptoms and weight loss, after infections and malignancies have been excluded.…”

Section: Discussionmentioning

confidence: 99%

Pancytopenia as a manifestation of late-onset systemic lupus erythematosus in an older patient: a case report

Han,

Yaakub,

Teo

2024

Asian Journal of Gerontology and Geriatrics

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Lupus érythémateux disséminé survenant après 65 ans

Cited by 23 publications

References 28 publications

Dermatology position paper on the revision of the 1982 ACR criteria for systemic lupus erythematosus

Dermatology position paper on the revision of the 1982 ACR criteria for systemic lupus erythematosus

Late–onset systemic lupus erythematosus-associated primary biliary cirrhosis

Pancytopenia as a manifestation of late-onset systemic lupus erythematosus in an older patient: a case report

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