Lupus érythémateux et atteinte unguéale : étude rétrospective sur 14 patients

Wagner, C.; Chasset, François; Françès, Camille; Lipsker, Dan

doi:10.1016/j.annder.2020.06.015

Cited by 3 publications

(4 citation statements)

References 41 publications

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“…This study affirms that nail alterations are common in patients with CTD (91% of our patients). This prevalence was among the highest reported in the international literature (25.45–80.6%) 5–10 …”

Section: Discussionmentioning

confidence: 70%

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Nail involvement in connective tissue diseases: an epidemiological, clinical, and dermoscopic study

Ghannem,

Zaouak,

Aydi

et al. 2024

Int J Dermatology

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BackgroundThe assessment of nail changes in connective tissue diseases (CTD) has been rarely explored in previous studies. The use of dermoscopy to study vascular changes in nailfolds is an interesting diagnostic technique. The aim of the study was to describe the epidemiological, clinical, and dermoscopic features of nail lesions in CTD.MethodsA prospective study was performed at the Dermatology Department of Habib Thameur Hospital (Tunis, Tunisia) in collaboration with the Internal Medicine Department over a period of 15 months, from July 2020 to September 2021, including patients diagnosed with systemic sclerosis (SS), systemic lupus erythematosus (SLE) and dermatomyositis (DM).ResultsOur study included 48 patients. Nail involvement was found in 44 cases. Dermoscopic nailfold abnormalities were identified in 37 cases. The most common clinical features were ragged cuticle, nailfold erythema, and onycholysis. Additionally, splinter hemorrhage, longitudinal ridging, lunula abnormalities, melanonychia, trachyonychia, leukonychia, increase in transverse curvature, parrot beak nail, half and half nails, and onychorrhexis were described. Nailfold dermoscopy showed a normal pattern in 10 cases, a nonspecific pattern in nine cases (SLE), and a scleroderma pattern in 29 cases (SS and DM). The scleroderma pattern was further categorized into an early pattern (6), an active pattern (14), and a late pattern (9). Normal pattern was observed solely in patients in remission. The late scleroderma pattern was associated with disease duration and systemic involvement. In SLE, disease activity correlated with onycholysis, nailfold erythema, and pathologic pattern in dermoscopy. However, patients with DM displayed a positive correlation between pulmonary involvement and scleroderma pattern.ConclusionNail involvement in CTD includes a diverse range of abnormalities. Despite being nonspecific, it can provide crucial clues for establishing a diagnosis. Nailfold dermoscopy serves as a mirror for microangiopathy, enabling the detection of changes at an initial stage, and thus, it becomes a diagnostic and prognostic tool.

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Section: Discussionmentioning

confidence: 70%

“…This prevalence was among the highest reported in the international literature (25.45-80.6%). [5][6][7][8][9][10] The main nail changes associated with CTD were nailfold erythema, ragged cuticle, and onycholysis. It appears that they are more frequently noted in patients presenting a severe disease course in SLE.…”

Section: Discussionmentioning

confidence: 99%

Nail involvement in connective tissue diseases: an epidemiological, clinical, and dermoscopic study

Ghannem,

Zaouak,

Aydi

et al. 2024

Int J Dermatology

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“…DLE affecting the nail apparatus is rare but well reported in the literature [1][2][3]. Lesions tend to be chronic and destructive, causing tissue atrophy in the same fashion as they do in other areas (skin atrophy and dyspigmentation, scarring alopecia).…”

Section: Discussionmentioning

confidence: 99%

“…Discoid lupus erythematosus (DLE) more commonly affects the face, ears, scalp, lips, and other sun-exposed areas. Periungual DLE is rare, and only a few publications deal with DLE located at this anatomic location [1][2][3]. Periungual DLE more usually occurs in persons with disseminated DLE [4].…”

Section: Introduction/literature Reviewmentioning

confidence: 99%

Squamous Cell Carcinoma Arising in Discoid Lupus Erythematosus of the Nail Unit

Yendo

Gabbi

Nico³

2023

Skin Appendage Disord

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Introduction: Discoid lupus erythematosus can affect periungual tissues leading to onychodystrophy. Squamous cell carcinoma can occur in persistent scars of discoid lupus; this rare occurrence has not yet been reported on the nail unit. Case presentation: we report a case of squamous cell carcinoma occurring on the distal phalanx of the thumb in a patient with longstanding periungual discoid lupus on several fingernails. Discussion: Periungual discoid lupus erythematosus is rare. The scars caused by this disease can very rarely develop into squamous cell carcinoma. This is the first report of this occurrence at the periungual tissues.

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Examination of the nails: Main signs

Arnal,

Richert

2024

Hand Surgery and Rehabilitation

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Lupus érythémateux et atteinte unguéale : étude rétrospective sur 14 patients

Cited by 3 publications

References 41 publications

Nail involvement in connective tissue diseases: an epidemiological, clinical, and dermoscopic study

Nail involvement in connective tissue diseases: an epidemiological, clinical, and dermoscopic study

Squamous Cell Carcinoma Arising in Discoid Lupus Erythematosus of the Nail Unit

Examination of the nails: Main signs

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