“…The nephrotic syndrome not uncommonly occurs in S.L.E. (Brenner et al, 1948;Daugherty and Baggenstoss, 1950;Dubois, 1953;Allen, 1955); in these cases wire-loop lesions are present in the glomeruli, and hypertension, too, often occurs in cases with renal involvement. Epileptic convulsions may be the first manifestation of S.L.E.…”