Lupus erythematosus with fatal hemorrhage into the liver and lesions resembling those of periarteritis nodosa and malignant hypertension

Immunofluorescent localization of immunoglobulins, complement, and fibrinogen in human diseases. I. Systemic lupus erythematosus.

“…Although y-globulin and complement have been demonstrated in the renal lesions of SLE (1)(2)(3)(4)(5)(6)(7)(8)(9)(10), the specific immunoglobulins have not been characterized. The presence of fibrin has been previously noted (8,10,11), but the relationship of glomerular fibrin deposition to renal damage has not been ascertained. Therefore, the fluorescent antibody technique was employed to study the localization of the following proteins in tissue lesions: 1) immunoglobulins (Y2-, y1M-, and ylA-globulins), 2) p1c-globulin (complement), 3) fibrinogen, and 4) other plasma proteins (a2-macroglobulin and albumin).…”

Ruptured renal microaneurysms complicated with a retroperitoneal abscess for a patient with systemic lupus erythematosus

“…Additionally, immune-mediated endothelial cell-injury due to renal artery vasculitis may be responsible for the sudden onset of renovascular hypertension, it having been previously reported that immunolgical reactions may play an important role in the genesis of systemic lupus erythematosus and malignant hypertension. 14 Classically, the characteristics of the different patient aneurysms may be different due to different etiologies. 12 Vasculitis-related aneurysms are, typically, multiple, fusiform, small and frequently found in atypical locations.…”

Review of American and English literature for the years 1963 and 1964 (Seventeenth Rheumatism Review)

“…Ed. ] It was considered possible that antibodies to nuclear and cytoplasmic constituents could combine with antigens derived f r o n damaged cells and that the resultant antigen-antibody complexes could give rise to glomerular and vascular lesions (81, 166,176,398,456,779,956,1239), decreased complement levels (840, 1263) and cryoprecipitation phenomena (227). It was also felt that antibodies to blood constituents might be playing a role in hemolytic anemia, thrombocytopenia and, perhaps, leukopenia in connective tissue disorders ( 1150); antibodies to clotting factors may also have contributed to hemorrhagic phenomena in some patients with lupus erythematosus ( 161,585).…”