Lupus Miliaris Disseminatus Faciei Part I: Significance of Histopathologic Undertones in Diagnosis

Abstract

The details of the various parameters were of great help in evolving this modus operandi. The clinical as well as histopathologic features of lupus miliaris disseminatus faciei are fairly distinct and facilitate visualizing the entity as a spectrum comprising early, fully developed, and late lesions. Further studies are called for.

Case for diagnosis. Eyelid edema and erythematous papules disseminated on the face

“…Its pattern may vary according to the stage of the lesion: early lesions are characterized by nonspecific and non-granulomatous inflammation, whereas well-developed lesions may present epithelioid granulomas with central necrosis, without central necrosis (sarcoid granuloma), or with abcess formation. 4 , 5 …”

Extrafacial nuchal lupus miliaris disseminatus faciei

“…Three histologic stages have been described: epithelioid cell granuloma without caseous necrosis, epithelioid cell granuloma with neutrophilic abscess formation, and epithelioid cell granuloma with caseous necrosis. Perifollicular fibrosis with scattered lymphocytes and histiocytes are seen in late lesions 7, 8…”

Morbihan disease and extrafacial lupus miliaris disseminatus faceie: a case report

“…Infiltrates comprising lymphocytes, histiocytes, and neutrophils are hallmarks of the condition. 6 LMDF is characterized by discrete brown/red to yellow dome-shaped papules on the face, including eyelids. 8 – 10 , 11 …”